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ANTsX / ANTsPy

A fast medical imaging analysis library in Python with algorithms for registration, segmentation, and more.
https://antspyx.readthedocs.io
Apache License 2.0
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ants.build_template: Rigid body registration #162

Closed vnckppl closed 4 years ago

vnckppl commented 4 years ago

Describe the bug When I run ants.build_template with type_of_transform="Rigid" it throws an error: Segmentation fault

To Reproduce The code below results in said error:

template = ants.build_template(
    intial_template=None,
    image_list=inputdata,
    iterations=3,
    gradient_step=0.2,
    blending_weight=0.75,
    weights=None,
    type_of_transform="Rigid",
    outprefix=odir + "/t",
    initial_transform=None,
    mask=None,
    grad_step=0.2,
    flow_sigma=3,
    total_sigma=0,
    aff_metric='mattes',
    aff_sampling=32,
    syn_metric='mattes',
    syn_sampling=32,
    reg_iterations=[30, 20, 10, 5],
    aff_iterations=[30, 20, 10, 5],
    aff_shrink_factors=[6, 4, 2, 1],
    aff_smoothing_sigmas=[3, 2, 1, 0],
    verbose=1
)

(the syn flags are redundant here obviously)

However, this code (without specifying the type_of_transform) runs fine:

template = ants.build_template(
    intial_template=None,
    image_list=inputdata,
    iterations=3,
    gradient_step=0.2,
    blending_weight=0.75,
    weights=None,
    outprefix=odir + "/t",
    initial_transform=None,
    mask=None,
    grad_step=0.2,
    flow_sigma=3,
    total_sigma=0,
    aff_metric='mattes',
    aff_sampling=32,
    syn_metric='mattes',
    syn_sampling=32,
    reg_iterations=[30, 20, 10, 5],
    aff_iterations=[30, 20, 10, 5],
    aff_shrink_factors=[6, 4, 2, 1],
    aff_smoothing_sigmas=[3, 2, 1, 0],
    verbose=1
)

This shorter snippet also results in 'Segmentation error':

template = ants.build_template(
    intial_template=None,
    image_list=inputdata,
    iterations=3,
    gradient_step=0.2,
    blending_weight=0.75,
    weights=None,
    type_of_transform="Rigid"

Terminal output

root@99d4c0e367f1:/data/in# python3 go.py
All_Command_lines_OK
Using single precision for computations.
=============================================================================
The composite transform comprises the following transforms (in order):
  1. Center of mass alignment using fixed image: 0x115e2460 and moving image: 0x10303f80 (type = Euler3DTransform)
=============================================================================
  Reading mask(s).
    Registration stage 0
      No fixed mask
      No moving mask
  number of levels = 4
  fixed image: 0x115e2460
  moving image: 0x10303f80
Dimension = 3
Number of stages = 1
Use Histogram Matching true
Winsorize image intensities false
Lower quantile = 0
Upper quantile = 1
Stage 1 State
   Image metric = Mattes
     Fixed image = Image (0x115116f0)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 931
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 903
  RealTimeStamp: 0 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [90, 65, 60]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [90, 65, 60]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [90, 65, 60]
  Spacing: [1.2, 1.01562, 1.01562]
  Origin: [53.9272, 71.6008, -62.2347]
  Direction:
-1 0 0
0 -1 0
0 0 1

  IndexToPointMatrix:
-1.2 0 0
0 -1.01562 0
0 0 1.01562

  PointToIndexMatrix:
-0.833335 0 0
0 -0.98462 0
0 0 0.98462

  Inverse Direction:
-1 0 0
0 -1 0
0 0 1

  PixelContainer:
    ImportImageContainer (0x103f6770)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 901
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x124a04b0
      Container manages memory: true
      Size: 351000
      Capacity: 351000

     Moving image = Image (0x1233c000)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 932
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 929
  RealTimeStamp: 0 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [90, 65, 60]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [90, 65, 60]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [90, 65, 60]
  Spacing: [1.2, 1.01562, 1.01562]
  Origin: [53.9272, 71.6008, -62.2347]
  Direction:
-1 0 0
0 -1 0
0 0 1

  IndexToPointMatrix:
-1.2 0 0
0 -1.01562 0
0 0 1.01562

  PointToIndexMatrix:
-0.833335 0 0
0 -0.98462 0
0 0 0.98462

  Inverse Direction:
-1 0 0
0 -1 0
0 0 1

  PixelContainer:
    ImportImageContainer (0x1124ea00)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 927
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x125f7120
      Container manages memory: true
      Size: 351000
      Capacity: 351000

     Weighting = 1
     Sampling strategy = regular
     Number of bins = 32
     Radius = 4
     Sampling percentage  = 0.2
   Transform = Rigid
     Gradient step = 0.25
     Update field sigma (voxel space) = 0
     Total field sigma (voxel space) = 0
     Update field time sigma = 0
     Total field time sigma  = 0
     Number of time indices = 0
     Number of time point samples = 0
Registration using 1 total stages.

Stage 0
  iterations = 2100x1200x1200x10
  convergence threshold = 1e-06
  convergence window size = 10
  number of levels = 4
  using the Mattes MI metric (number of bins = 32, weight = 1)
  preprocessing:  histogram matching the images
  Shrink factors (level 1 out of 4): [5, 6, 6]
  Shrink factors (level 2 out of 4): [3, 4, 4]
  Shrink factors (level 3 out of 4): [2, 2, 2]
  Shrink factors (level 4 out of 4): [1, 1, 1]
  smoothing sigmas per level: [3, 2, 1, 0]
  regular sampling (percentage = 0.2)

*** Running Euler3DTransform registration ***

DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -5.720419883728e-01, inf, 2.5961e-02, 2.5961e-02,
 2DIAGNOSTIC,     2, -5.872725844383e-01, inf, 2.7719e-02, 1.7581e-03,
 2DIAGNOSTIC,     3, -6.312068104744e-01, inf, 2.9798e-02, 2.0790e-03,
 2DIAGNOSTIC,     4, -6.567739844322e-01, inf, 3.4530e-02, 4.7319e-03,
 2DIAGNOSTIC,     5, -6.749777793884e-01, inf, 3.9924e-02, 5.3940e-03,
 2DIAGNOSTIC,     6, -6.779276728630e-01, inf, 4.4783e-02, 4.8590e-03,
 2DIAGNOSTIC,     7, -6.780894398689e-01, inf, 4.8604e-02, 3.8209e-03,
 2DIAGNOSTIC,     8, -6.781620979309e-01, inf, 5.2403e-02, 3.7990e-03,
 2DIAGNOSTIC,     9, -6.781682968140e-01, inf, 5.5207e-02, 2.8040e-03,
 2DIAGNOSTIC,    10, -6.781704425812e-01, 9.993894025683e-03, 5.9344e-02, 4.1370e-03,
 2DIAGNOSTIC,    11, -6.781729459763e-01, 5.870681256056e-03, 6.4459e-02, 5.1150e-03,
 2DIAGNOSTIC,    12, -6.781723499298e-01, 2.459577517584e-03, 6.9682e-02, 5.2228e-03,
 2DIAGNOSTIC,    13, -6.781723499298e-01, 8.138568955474e-04, 7.3802e-02, 4.1208e-03,
 2DIAGNOSTIC,    14, -6.781720519066e-01, 1.092897437047e-04, 7.7520e-02, 3.7172e-03,
 2DIAGNOSTIC,    15, -6.781718134880e-01, 1.152813547378e-05, 8.1350e-02, 3.8302e-03,
 2DIAGNOSTIC,    16, -6.781717538834e-01, 4.569494649331e-06, 8.5760e-02, 4.4100e-03,
 2DIAGNOSTIC,    17, -6.781715750694e-01, 2.245063797091e-06, 8.9585e-02, 3.8249e-03,
 2DIAGNOSTIC,    18, -6.781717538834e-01, 1.885815663627e-06, 9.3358e-02, 3.7730e-03,
 2DIAGNOSTIC,    19, -6.781716942787e-01, 1.695219907560e-06, 9.7769e-02, 4.4110e-03,
 2DIAGNOSTIC,    20, -6.781712770462e-01, 1.560830696690e-06, 1.0219e-01, 4.4239e-03,
 2DIAGNOSTIC,    21, -6.781712174416e-01, 1.495538299423e-06, 1.0597e-01, 3.7742e-03,
 2DIAGNOSTIC,    22, -6.781714558601e-01, 1.433686747987e-06, 1.0966e-01, 3.6979e-03,
 2DIAGNOSTIC,    23, -6.781710386276e-01, 1.372977976644e-06, 1.1391e-01, 4.2431e-03,
 2DIAGNOSTIC,    24, -6.781712770462e-01, 1.319906345998e-06, 1.1891e-01, 5.0030e-03,
 2DIAGNOSTIC,    25, -6.781712174416e-01, 1.268712708224e-06, 1.2445e-01, 5.5358e-03,
 2DIAGNOSTIC,    26, -6.781709790230e-01, 1.219008368025e-06, 1.2927e-01, 4.8280e-03,
 2DIAGNOSTIC,    27, -6.781712770462e-01, 1.177043941425e-06, 1.3440e-01, 5.1229e-03,
 2DIAGNOSTIC,    28, -6.781714558601e-01, 1.145135456682e-06, 1.3883e-01, 4.4341e-03,
 2DIAGNOSTIC,    29, -6.781710386276e-01, 1.109266577259e-06, 1.4259e-01, 3.7541e-03,
 2DIAGNOSTIC,    30, -6.781713962555e-01, 1.075495561054e-06, 1.4645e-01, 3.8650e-03,
 2DIAGNOSTIC,    31, -6.781712770462e-01, 1.041156565407e-06, 1.5012e-01, 3.6719e-03,
 2DIAGNOSTIC,    32, -6.781713366508e-01, 1.012910729514e-06, 1.5443e-01, 4.3070e-03,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -6.464282274246e-01, inf, 1.7693e-01, 2.2503e-02,
 2DIAGNOSTIC,     2, -6.637206673622e-01, inf, 1.7981e-01, 2.8820e-03,
 2DIAGNOSTIC,     3, -6.754683256149e-01, inf, 1.8231e-01, 2.4941e-03,
 2DIAGNOSTIC,     4, -6.782192587852e-01, inf, 1.8553e-01, 3.2170e-03,
 2DIAGNOSTIC,     5, -6.788809895515e-01, inf, 1.9349e-01, 7.9641e-03,
 2DIAGNOSTIC,     6, -6.788806915283e-01, inf, 1.9693e-01, 3.4361e-03,
 2DIAGNOSTIC,     7, -6.788814663887e-01, inf, 1.9988e-01, 2.9550e-03,
 2DIAGNOSTIC,     8, -6.788833141327e-01, inf, 2.0255e-01, 2.6710e-03,
 2DIAGNOSTIC,     9, -6.788861155510e-01, inf, 2.0488e-01, 2.3310e-03,
 2DIAGNOSTIC,    10, -6.788909435272e-01, 2.045713365078e-03, 2.0705e-01, 2.1651e-03,
 2DIAGNOSTIC,    11, -6.788986325264e-01, 7.171591278166e-04, 2.0932e-01, 2.2690e-03,
 2DIAGNOSTIC,    12, -6.789129972458e-01, 1.447891118005e-04, 2.1169e-01, 2.3680e-03,
 2DIAGNOSTIC,    13, -6.789348721504e-01, 2.711409433687e-05, 2.1386e-01, 2.1791e-03,
 2DIAGNOSTIC,    14, -6.789716482162e-01, 7.337946044572e-06, 2.1599e-01, 2.1210e-03,
 2DIAGNOSTIC,    15, -6.790317893028e-01, 9.982875781134e-06, 2.1815e-01, 2.1629e-03,
 2DIAGNOSTIC,    16, -6.791278719902e-01, 1.406538922311e-05, 2.2042e-01, 2.2688e-03,
 2DIAGNOSTIC,    17, -6.792722344398e-01, 2.010179196077e-05, 2.2286e-01, 2.4381e-03,
 2DIAGNOSTIC,    18, -6.793611645699e-01, 2.584402864159e-05, 2.2549e-01, 2.6331e-03,
 2DIAGNOSTIC,    19, -6.788343191147e-01, 1.715946564218e-05, 2.2799e-01, 2.5001e-03,
 2DIAGNOSTIC,    20, -6.789813637733e-01, 1.146225804405e-05, 2.3044e-01, 2.4562e-03,
 2DIAGNOSTIC,    21, -6.803479194641e-01, 3.265837221988e-05, 2.3297e-01, 2.5282e-03,
 2DIAGNOSTIC,    22, -6.804909706116e-01, 5.109454286867e-05, 2.3562e-01, 2.6510e-03,
 2DIAGNOSTIC,    23, -6.805595159531e-01, 6.521695468109e-05, 2.3851e-01, 2.8880e-03,
 2DIAGNOSTIC,    24, -6.811937689781e-01, 8.446404535789e-05, 2.4219e-01, 3.6781e-03,
 2DIAGNOSTIC,    25, -6.805840134621e-01, 8.479665848427e-05, 2.4500e-01, 2.8090e-03,
 2DIAGNOSTIC,    26, -6.812072992325e-01, 8.870055899024e-05, 2.4813e-01, 3.1271e-03,
 2DIAGNOSTIC,    27, -6.812172532082e-01, 8.602103480371e-05, 2.5237e-01, 4.2410e-03,
 2DIAGNOSTIC,    28, -6.805853247643e-01, 6.788766768295e-05, 2.5529e-01, 2.9221e-03,
 2DIAGNOSTIC,    29, -6.812195777893e-01, 4.675452146330e-05, 2.5772e-01, 2.4312e-03,
 2DIAGNOSTIC,    30, -6.812245249748e-01, 2.405742998235e-05, 2.6022e-01, 2.4991e-03,
 2DIAGNOSTIC,    31, -6.812300086021e-01, 1.915530265251e-05, 2.6334e-01, 3.1180e-03,
 2DIAGNOSTIC,    32, -6.812334656715e-01, 1.483935557189e-05, 2.6630e-01, 2.9621e-03,
 2DIAGNOSTIC,    33, -6.812353134155e-01, 1.027732105285e-05, 2.6917e-01, 2.8679e-03,
 2DIAGNOSTIC,    34, -6.812357306480e-01, 1.313136090175e-05, 2.7187e-01, 2.6991e-03,
 2DIAGNOSTIC,    35, -6.812362670898e-01, 7.005611223576e-06, 2.7466e-01, 2.7952e-03,
 2DIAGNOSTIC,    36, -6.812375783920e-01, 7.937699592730e-06, 2.7730e-01, 2.6429e-03,
 2DIAGNOSTIC,    37, -6.812391281128e-01, 8.569939382141e-06, 2.7998e-01, 2.6782e-03,
 2DIAGNOSTIC,    38, -6.812416315079e-01, 1.297814378631e-06, 2.8278e-01, 2.7990e-03,
 2DIAGNOSTIC,    39, -6.812439560890e-01, 1.191434307657e-06, 2.8594e-01, 3.1559e-03,
 2DIAGNOSTIC,    40, -6.812446117401e-01, 1.112335439757e-06, 2.8919e-01, 3.2520e-03,
 2DIAGNOSTIC,    41, -6.812466382980e-01, 1.083321535589e-06, 2.9496e-01, 5.7681e-03,
 2DIAGNOSTIC,    42, -6.812457442284e-01, 1.051240815286e-06, 2.9878e-01, 3.8209e-03,
 2DIAGNOSTIC,    43, -6.812462806702e-01, 1.016245391838e-06, 3.0229e-01, 3.5081e-03,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -7.143755555153e-01, inf, 3.3076e-01, 2.8469e-02,
 2DIAGNOSTIC,     2, -7.198663353920e-01, inf, 3.3830e-01, 7.5490e-03,
 2DIAGNOSTIC,     3, -7.212307453156e-01, inf, 3.4731e-01, 9.0051e-03,
 2DIAGNOSTIC,     4, -7.217882871628e-01, inf, 3.5528e-01, 7.9739e-03,
 2DIAGNOSTIC,     5, -7.216019630432e-01, inf, 3.6482e-01, 9.5401e-03,
 2DIAGNOSTIC,     6, -7.216446995735e-01, inf, 3.7330e-01, 8.4789e-03,
 2DIAGNOSTIC,     7, -7.213369607925e-01, inf, 3.8046e-01, 7.1530e-03,
 2DIAGNOSTIC,     8, -7.213340401649e-01, inf, 3.8878e-01, 8.3251e-03,
 2DIAGNOSTIC,     9, -7.213413715363e-01, inf, 4.0079e-01, 1.2010e-02,
 2DIAGNOSTIC,    10, -7.213335037231e-01, 3.232688177377e-04, 4.0879e-01, 7.9999e-03,
 2DIAGNOSTIC,    11, -7.213334441185e-01, 4.115283081774e-05, 4.1717e-01, 8.3811e-03,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -6.912285089493e-01, inf, 4.9800e-01, 8.0827e-02,
 2DIAGNOSTIC,     2, -6.926645040512e-01, inf, 5.5766e-01, 5.9661e-02,
 2DIAGNOSTIC,     3, -6.927680969238e-01, inf, 6.0724e-01, 4.9585e-02,
 2DIAGNOSTIC,     4, -6.927915215492e-01, inf, 6.5603e-01, 4.8783e-02,
 2DIAGNOSTIC,     5, -6.927404403687e-01, inf, 7.0715e-01, 5.1118e-02,
 2DIAGNOSTIC,     6, -6.926997303963e-01, inf, 7.5999e-01, 5.2840e-02,
 2DIAGNOSTIC,     7, -6.927160620689e-01, inf, 8.1797e-01, 5.7981e-02,
 2DIAGNOSTIC,     8, -6.927124261856e-01, inf, 8.8022e-01, 6.2257e-02,
 2DIAGNOSTIC,     9, -6.927049756050e-01, inf, 9.3282e-01, 5.2596e-02,
 2DIAGNOSTIC,    10, -6.927049160004e-01, 6.189383566380e-05, 9.8272e-01, 4.9898e-02,
  Elapsed time (stage 0): 1.0413e+00

Total elapsed time: 1.0455e+00
Segmentation fault

Question: What is the correct way of creating a template using only rigid body registration with ants.build_template?

Desktop (please complete the following information):

stnava commented 4 years ago

we will fix this later but I would recommend for now just registering your data to a fixed template, then averaging the results. you would pass the outcome as initial template to the bt function.

vnckppl commented 4 years ago

Alright! For now, I just set the reg_iterations to 0. This does indeed set the SyN iterations to 0. Interestingly, the settings for the affine iterations do not seem to get passed down to registration:

Script I run:

# * Modules
import os
import ants

# * Environment
base = '/data'
idir = os.path.join(base, "in")
odir = os.path.join(base, "out")
os.makedirs(odir, exist_ok=True)

# * Load data
inputdata = [
    ants.image_read(os.path.join(idir, 'sub-A22.nii.gz')),
    ants.image_read(os.path.join(idir, 'sub-A24.nii.gz'))
]

# * Build template
template = ants.build_template(
    intial_template=None,
    image_list=inputdata,
    iterations=3,
    gradient_step=0.2,
    blending_weight=0.75,
    weights=None,
    type_of_transform="SyN",
    outprefix=odir + "/t",
    initial_transform=None,
    mask=None,
    grad_step=0.2,
    flow_sigma=3,
    total_sigma=0,
    aff_metric='mattes',
    aff_sampling=32,
    syn_metric='mattes',
    syn_sampling=32,
    reg_iterations=[0, 0, 0, 0],
    aff_iterations=[40, 20, 10, 5],
    aff_shrink_factors=[6, 4, 2, 1],
    aff_smoothing_sigmas=[3, 2, 1, 0],
    verbose=1
)

ANTs terminal output:

All_Command_lines_OK
Using single precision for computations.
=============================================================================
The composite transform comprises the following transforms (in order):
  1. Center of mass alignment using fixed image: 0x1232c4d0 and moving image: 0x1177ae90 (type = Euler3DTransform)
=============================================================================
  Reading mask(s).
    Registration stage 0
      No fixed mask
      No moving mask
    Registration stage 1
      No fixed mask
      No moving mask
  number of levels = 4
  number of levels = 4
  fixed image: 0x1232c4d0
  moving image: 0x1177ae90
  fixed image: 0x1232c4d0
  moving image: 0x1177ae90
Dimension = 3
Number of stages = 2
Use Histogram Matching true
Winsorize image intensities false
Lower quantile = 0
Upper quantile = 1
Stage 1 State
   Image metric = Mattes
     Fixed image = Image (0x127adc40)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 955
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 929
  RealTimeStamp: 0 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1, 1, 1]
  Origin: [90.2118, 89.8711, -138.525]
  Direction:
-1 0 0
0 -1 0
0 0 1

  IndexToPointMatrix:
-1 0 0
0 -1 0
0 0 1

  PointToIndexMatrix:
-1 0 0
0 -1 0
0 0 1

  Inverse Direction:
-1 0 0
0 -1 0
0 0 1

  PixelContainer:
    ImportImageContainer (0x11906500)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 927
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff7916bf010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Moving image = Image (0x127c2310)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 956
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 953
  RealTimeStamp: 0 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1, 1, 1]
  Origin: [90.2118, 89.8711, -138.525]
  Direction:
-1 0 0
0 -1 0
0 0 1

  IndexToPointMatrix:
-1 0 0
0 -1 0
0 0 1

  PointToIndexMatrix:
-1 0 0
0 -1 0
0 0 1

  Inverse Direction:
-1 0 0
0 -1 0
0 0 1

  PixelContainer:
    ImportImageContainer (0x10b99a40)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 951
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff77d6bf010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Weighting = 1
     Sampling strategy = regular
     Number of bins = 32
     Radius = 4
     Sampling percentage  = 0.2
   Transform = Affine
     Gradient step = 0.25
     Update field sigma (voxel space) = 0
     Total field sigma (voxel space) = 0
     Update field time sigma = 0
     Total field time sigma  = 0
     Number of time indices = 0
     Number of time point samples = 0
Stage 2 State
   Image metric = Mattes
     Fixed image = Image (0x127c31a0)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 1005
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 979
  RealTimeStamp: 0 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1, 1, 1]
  Origin: [90.2118, 89.8711, -138.525]
  Direction:
-1 0 0
0 -1 0
0 0 1

  IndexToPointMatrix:
-1 0 0
0 -1 0
0 0 1

  PointToIndexMatrix:
-1 0 0
0 -1 0
0 0 1

  Inverse Direction:
-1 0 0
0 -1 0
0 0 1

  PixelContainer:
    ImportImageContainer (0x12757890)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 977
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff7756bf010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Moving image = Image (0x127c3460)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 1006
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 1003
  RealTimeStamp: 0 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1, 1, 1]
  Origin: [90.2118, 89.8711, -138.525]
  Direction:
-1 0 0
0 -1 0
0 0 1

  IndexToPointMatrix:
-1 0 0
0 -1 0
0 0 1

  PointToIndexMatrix:
-1 0 0
0 -1 0
0 0 1

  Inverse Direction:
-1 0 0
0 -1 0
0 0 1

  PixelContainer:
    ImportImageContainer (0x10c2ba80)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 1001
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff772d7e010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Weighting = 1
     Sampling strategy = none
     Number of bins = 32
     Radius = 4
     Sampling percentage  = 1
   Transform = SyN
     Gradient step = 0.2
     Update field sigma (voxel space) = 3
     Total field sigma (voxel space) = 0
     Update field time sigma = 0
     Total field time sigma  = 0
     Number of time indices = 0
     Number of time point samples = 0
Registration using 2 total stages.

Stage 0
  iterations = 2100x1200x1200x0
  convergence threshold = 1e-06
  convergence window size = 10
  number of levels = 4
  using the Mattes MI metric (number of bins = 32, weight = 1)
  preprocessing:  histogram matching the images
  Shrink factors (level 1 out of 4): [4, 4, 4]
  Shrink factors (level 2 out of 4): [2, 2, 2]
  Shrink factors (level 3 out of 4): [2, 2, 2]
  Shrink factors (level 4 out of 4): [1, 1, 1]
  smoothing sigmas per level: [3, 2, 1, 0]
  regular sampling (percentage = 0.2)

*** Running AffineTransform registration ***

DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -8.626515865326e-01, inf, 4.3895e-01, 4.3895e-01,
 2DIAGNOSTIC,     2, -8.723759651184e-01, inf, 4.7628e-01, 3.7327e-02,
 2DIAGNOSTIC,     3, -8.857799172401e-01, inf, 5.1655e-01, 4.0266e-02,
 2DIAGNOSTIC,     4, -9.009484648705e-01, inf, 5.5382e-01, 3.7276e-02,
 2DIAGNOSTIC,     5, -9.129993319511e-01, inf, 5.9501e-01, 4.1190e-02,
 2DIAGNOSTIC,     6, -9.185264110565e-01, inf, 6.3363e-01, 3.8618e-02,
 2DIAGNOSTIC,     7, -9.188471436501e-01, inf, 6.8550e-01, 5.1869e-02,
 2DIAGNOSTIC,     8, -9.191570281982e-01, inf, 7.3108e-01, 4.5582e-02,
 2DIAGNOSTIC,     9, -9.192845225334e-01, inf, 7.8789e-01, 5.6807e-02,
 2DIAGNOSTIC,    10, -9.196040630341e-01, 4.114751704037e-03, 8.9184e-01, 1.0396e-01,
 2DIAGNOSTIC,    11, -9.198276996613e-01, 2.653704024851e-03, 9.7904e-01, 8.7193e-02,
 2DIAGNOSTIC,    12, -9.198348522186e-01, 1.456175232306e-03, 1.0214e+00, 4.2350e-02,
 2DIAGNOSTIC,    13, -9.198894500732e-01, 6.340758409351e-04, 1.0669e+00, 4.5546e-02,
 2DIAGNOSTIC,    14, -9.199307560921e-01, 2.076169912471e-04, 1.1241e+00, 5.7210e-02,
 2DIAGNOSTIC,    15, -9.199666380882e-01, 6.876894622110e-05, 1.1688e+00, 4.4688e-02,
 2DIAGNOSTIC,    16, -9.199828505516e-01, 4.950040238327e-05, 1.2166e+00, 4.7800e-02,
 2DIAGNOSTIC,    17, -9.200027585030e-01, 3.436408587731e-05, 1.2636e+00, 4.6946e-02,
 2DIAGNOSTIC,    18, -9.200670123100e-01, 2.446801045153e-05, 1.3155e+00, 5.1971e-02,
 2DIAGNOSTIC,    19, -9.201495051384e-01, 1.682765650912e-05, 1.3750e+00, 5.9477e-02,
 2DIAGNOSTIC,    20, -9.202396869659e-01, 1.482303105149e-05, 1.4592e+00, 8.4171e-02,
 2DIAGNOSTIC,    21, -9.203066825867e-01, 1.609507671674e-05, 1.5395e+00, 8.0289e-02,
 2DIAGNOSTIC,    22, -9.203132987022e-01, 1.607734338904e-05, 1.6031e+00, 6.3615e-02,
 2DIAGNOSTIC,    23, -9.203090667725e-01, 1.537762727821e-05, 1.6545e+00, 5.1363e-02,
 2DIAGNOSTIC,    24, -9.204297065735e-01, 1.551140667289e-05, 1.7105e+00, 5.6000e-02,
 2DIAGNOSTIC,    25, -9.205038547516e-01, 1.561537465022e-05, 1.7555e+00, 4.5036e-02,
 2DIAGNOSTIC,    26, -9.205160737038e-01, 1.469566541346e-05, 1.8060e+00, 5.0529e-02,
 2DIAGNOSTIC,    27, -9.205092191696e-01, 1.275928389077e-05, 1.8501e+00, 4.4043e-02,
 2DIAGNOSTIC,    28, -9.205016493797e-01, 1.051104572980e-05, 1.9065e+00, 5.6386e-02,
 2DIAGNOSTIC,    29, -9.205017685890e-01, 8.381062798435e-06, 1.9513e+00, 4.4796e-02,
 2DIAGNOSTIC,    30, -9.205021858215e-01, 6.604633199458e-06, 1.9962e+00, 4.4959e-02,
 2DIAGNOSTIC,    31, -9.204847812653e-01, 4.927934696752e-06, 2.0478e+00, 5.1562e-02,
 2DIAGNOSTIC,    32, -9.204842448235e-01, 3.079553835050e-06, 2.0943e+00, 4.6556e-02,
 2DIAGNOSTIC,    33, -9.204847812653e-01, 1.089287479772e-06, 2.1401e+00, 4.5800e-02,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -8.432794809341e-01, inf, 2.8713e+00, 7.3119e-01,
 2DIAGNOSTIC,     2, -8.449099659920e-01, inf, 3.0724e+00, 2.0112e-01,
 2DIAGNOSTIC,     3, -8.459258675575e-01, inf, 3.3080e+00, 2.3552e-01,
 2DIAGNOSTIC,     4, -8.465425372124e-01, inf, 3.5882e+00, 2.8020e-01,
 2DIAGNOSTIC,     5, -8.466435074806e-01, inf, 3.7823e+00, 1.9417e-01,
 2DIAGNOSTIC,     6, -8.468798995018e-01, inf, 3.9758e+00, 1.9349e-01,
 2DIAGNOSTIC,     7, -8.470389842987e-01, inf, 4.1745e+00, 1.9872e-01,
 2DIAGNOSTIC,     8, -8.471636176109e-01, inf, 4.3953e+00, 2.2077e-01,
 2DIAGNOSTIC,     9, -8.472023606300e-01, inf, 4.5907e+00, 1.9535e-01,
 2DIAGNOSTIC,    10, -8.472434878349e-01, 2.418425574433e-04, 4.8685e+00, 2.7780e-01,
 2DIAGNOSTIC,    11, -8.472418189049e-01, 1.315730914939e-04, 5.0790e+00, 2.1050e-01,
 2DIAGNOSTIC,    12, -8.472446203232e-01, 7.322182500502e-05, 5.2935e+00, 2.1457e-01,
 2DIAGNOSTIC,    13, -8.472439050674e-01, 4.331857417128e-05, 5.5186e+00, 2.2511e-01,
 2DIAGNOSTIC,    14, -8.472425937653e-01, 2.876647704397e-05, 5.7399e+00, 2.2129e-01,
 2DIAGNOSTIC,    15, -8.472471833229e-01, 1.601983058208e-05, 5.9841e+00, 2.4416e-01,
 2DIAGNOSTIC,    16, -8.472478985786e-01, 8.510806765116e-06, 6.2310e+00, 2.4692e-01,
 2DIAGNOSTIC,    17, -8.472498655319e-01, 4.416933734319e-06, 6.5466e+00, 3.1556e-01,
 2DIAGNOSTIC,    18, -8.472512960434e-01, 2.882654143832e-06, 6.8851e+00, 3.3858e-01,
 2DIAGNOSTIC,    19, -8.472514152527e-01, 2.072904635497e-06, 7.1350e+00, 2.4983e-01,
 2DIAGNOSTIC,    20, -8.472514152527e-01, 1.998108018597e-06, 7.3743e+00, 2.3928e-01,
 2DIAGNOSTIC,    21, -8.472512364388e-01, 1.861065925368e-06, 7.6245e+00, 2.5022e-01,
 2DIAGNOSTIC,    22, -8.472510576248e-01, 1.744934365888e-06, 7.8503e+00, 2.2578e-01,
 2DIAGNOSTIC,    23, -8.472510576248e-01, 1.601665871931e-06, 8.1010e+00, 2.5077e-01,
 2DIAGNOSTIC,    24, -8.472508788109e-01, 1.427630309081e-06, 8.3191e+00, 2.1806e-01,
 2DIAGNOSTIC,    25, -8.472509384155e-01, 1.320785145253e-06, 8.5593e+00, 2.4026e-01,
 2DIAGNOSTIC,    26, -8.472510576248e-01, 1.227954726346e-06, 8.7870e+00, 2.2767e-01,
 2DIAGNOSTIC,    27, -8.472509980202e-01, 1.164822151623e-06, 9.0000e+00, 2.1299e-01,
 2DIAGNOSTIC,    28, -8.472509980202e-01, 1.124639311456e-06, 9.2153e+00, 2.1526e-01,
 2DIAGNOSTIC,    29, -8.472509980202e-01, 1.089719489755e-06, 9.4459e+00, 2.3068e-01,
 2DIAGNOSTIC,    30, -8.472509384155e-01, 1.057194708665e-06, 9.6737e+00, 2.2772e-01,
 2DIAGNOSTIC,    31, -8.472509384155e-01, 1.025189476422e-06, 9.8909e+00, 2.1729e-01,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -7.674462199211e-01, inf, 1.0676e+01, 7.8470e-01,
 2DIAGNOSTIC,     2, -7.698264122009e-01, inf, 1.0883e+01, 2.0733e-01,
 2DIAGNOSTIC,     3, -7.708185315132e-01, inf, 1.1118e+01, 2.3487e-01,
 2DIAGNOSTIC,     4, -7.715876102448e-01, inf, 1.1434e+01, 3.1655e-01,
 2DIAGNOSTIC,     5, -7.717050313950e-01, inf, 1.1629e+01, 1.9416e-01,
 2DIAGNOSTIC,     6, -7.719827890396e-01, inf, 1.1831e+01, 2.0284e-01,
 2DIAGNOSTIC,     7, -7.721413373947e-01, inf, 1.2020e+01, 1.8868e-01,
 2DIAGNOSTIC,     8, -7.722641825676e-01, inf, 1.2215e+01, 1.9462e-01,
 2DIAGNOSTIC,     9, -7.723864912987e-01, inf, 1.2424e+01, 2.0948e-01,
 2DIAGNOSTIC,    10, -7.724842429161e-01, 3.198682097718e-04, 1.2706e+01, 2.8135e-01,
 2DIAGNOSTIC,    11, -7.725003361702e-01, 1.696046238067e-04, 1.3051e+01, 3.4523e-01,
 2DIAGNOSTIC,    12, -7.725021243095e-01, 1.020242561935e-04, 1.3277e+01, 2.2631e-01,
 2DIAGNOSTIC,    13, -7.725023627281e-01, 6.350549665513e-05, 1.3512e+01, 2.3478e-01,
 2DIAGNOSTIC,    14, -7.725011706352e-01, 4.515195541899e-05, 1.3708e+01, 1.9607e-01,
 2DIAGNOSTIC,    15, -7.725012898445e-01, 2.806895463436e-05, 1.3906e+01, 1.9780e-01,
 2DIAGNOSTIC,    16, -7.725023031235e-01, 1.712107223284e-05, 1.4095e+01, 1.8935e-01,
 2DIAGNOSTIC,    17, -7.725066542625e-01, 9.585402040102e-06, 1.4319e+01, 2.2441e-01,
 2DIAGNOSTIC,    18, -7.725116014481e-01, 4.744986654259e-06, 1.4516e+01, 1.9636e-01,
 2DIAGNOSTIC,    19, -7.725189924240e-01, 2.601260348456e-06, 1.4748e+01, 2.3188e-01,
 2DIAGNOSTIC,    20, -7.725212574005e-01, 2.417849600533e-06, 1.4952e+01, 2.0454e-01,
 2DIAGNOSTIC,    21, -7.725260853767e-01, 2.541827598179e-06, 1.5145e+01, 1.9238e-01,
 2DIAGNOSTIC,    22, -7.725411057472e-01, 2.838261025317e-06, 1.5368e+01, 2.2315e-01,
 2DIAGNOSTIC,    23, -7.725440859795e-01, 3.023689714610e-06, 1.5575e+01, 2.0717e-01,
 2DIAGNOSTIC,    24, -7.725478410721e-01, 3.080843498537e-06, 1.5993e+01, 4.1807e-01,
 2DIAGNOSTIC,    25, -7.725490331650e-01, 2.990829898408e-06, 1.6222e+01, 2.2867e-01,
 2DIAGNOSTIC,    26, -7.725481390953e-01, 2.747450935203e-06, 1.6481e+01, 2.5958e-01,
 2DIAGNOSTIC,    27, -7.725480794907e-01, 2.434462885503e-06, 1.6707e+01, 2.2618e-01,
 2DIAGNOSTIC,    28, -7.725482583046e-01, 2.089965619234e-06, 1.6933e+01, 2.2591e-01,
 2DIAGNOSTIC,    29, -7.725477814674e-01, 1.768746187736e-06, 1.7145e+01, 2.1131e-01,
 2DIAGNOSTIC,    30, -7.725473642349e-01, 1.429084477422e-06, 1.7370e+01, 2.2485e-01,
 2DIAGNOSTIC,    31, -7.725478410721e-01, 1.135764478022e-06, 1.7595e+01, 2.2557e-01,
 2DIAGNOSTIC,    32, -7.725481390953e-01, 1.026153654493e-06, 1.7817e+01, 2.2155e-01,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -6.952929496765e-01, inf, 2.0188e+01, 2.3711e+00,
  Elapsed time (stage 0): 2.1164e+01

Stage 1
  iterations = 0x0x0x0
  convergence threshold = 1.0000e-07
  convergence window size = 8
  number of levels = 4
  using the Mattes MI metric (number of bins = 32, weight = 1.0000e+00)
  preprocessing:  histogram matching the images
  Shrink factors (level 1 out of 4): [8, 8, 8]
  Shrink factors (level 2 out of 4): [4, 4, 4]
  Shrink factors (level 3 out of 4): [2, 2, 2]
  Shrink factors (level 4 out of 4): [1, 1, 1]
  smoothing sigmas per level: [3, 2, 1, 0]
  Using default NONE metricSamplingStrategy

*** Running SyN registration (varianceForUpdateField = 3.0000e+00, varianceForTotalField = 0.0000e+00) ***

  Elapsed time (stage 1): 4.2371e+00

Total elapsed time: 2.5429e+01
All_Command_lines_OK
Using single precision for computations.
=============================================================================
The composite transform comprises the following transforms (in order):
  1. Center of mass alignment using fixed image: 0x10bacfe0 and moving image: 0x117275a0 (type = Euler3DTransform)
=============================================================================
  Reading mask(s).
    Registration stage 0
      No fixed mask
      No moving mask
    Registration stage 1
      No fixed mask
      No moving mask
  number of levels = 4
  number of levels = 4
  fixed image: 0x10bacfe0
  moving image: 0x117275a0
  fixed image: 0x10bacfe0
  moving image: 0x117275a0
Dimension = 3
Number of stages = 2
Use Histogram Matching true
Winsorize image intensities false
Lower quantile = 0.0000e+00
Upper quantile = 1.0000e+00
Stage 1 State
   Image metric = Mattes
     Fixed image = Image (0x128196d0)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 5497140
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 5497114
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [9.0212e+01, 8.9871e+01, -1.3853e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x11906500)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 5497112
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff772d7e010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Moving image = Image (0x127d3620)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 5497141
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 5497138
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [8.6557e+01, 8.7864e+01, -1.4492e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x10fe8b50)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 5497136
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff77043d010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Weighting = 1.0000e+00
     Sampling strategy = regular
     Number of bins = 32
     Radius = 4
     Sampling percentage  = 2.0000e-01
   Transform = Affine
     Gradient step = 2.5000e-01
     Update field sigma (voxel space) = 0.0000e+00
     Total field sigma (voxel space) = 0.0000e+00
     Update field time sigma = 0.0000e+00
     Total field time sigma  = 0.0000e+00
     Number of time indices = 0
     Number of time point samples = 0
Stage 2 State
   Image metric = Mattes
     Fixed image = Image (0x127d5160)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 5497190
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 5497164
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [9.0212e+01, 8.9871e+01, -1.3853e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x1043e8d0)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 5497162
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff76dafc010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Moving image = Image (0x127d5420)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 5497191
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 5497188
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [8.6557e+01, 8.7864e+01, -1.4492e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x10feb9e0)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 5497186
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff76b1bb010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Weighting = 1.0000e+00
     Sampling strategy = none
     Number of bins = 32
     Radius = 4
     Sampling percentage  = 1.0000e+00
   Transform = SyN
     Gradient step = 2.0000e-01
     Update field sigma (voxel space) = 3.0000e+00
     Total field sigma (voxel space) = 0.0000e+00
     Update field time sigma = 0.0000e+00
     Total field time sigma  = 0.0000e+00
     Number of time indices = 0
     Number of time point samples = 0
Registration using 2 total stages.

Stage 0
  iterations = 2100x1200x1200x0
  convergence threshold = 1.0000e-06
  convergence window size = 10
  number of levels = 4
  using the Mattes MI metric (number of bins = 32, weight = 1.0000e+00)
  preprocessing:  histogram matching the images
  Shrink factors (level 1 out of 4): [4, 4, 4]
  Shrink factors (level 2 out of 4): [2, 2, 2]
  Shrink factors (level 3 out of 4): [2, 2, 2]
  Shrink factors (level 4 out of 4): [1, 1, 1]
  smoothing sigmas per level: [3, 2, 1, 0]
  regular sampling (percentage = 2.0000e-01)

*** Running AffineTransform registration ***

DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -6.075606942177e-01, inf, 4.7706e-01, 4.7706e-01,
 2DIAGNOSTIC,     2, -6.107954978943e-01, inf, 5.2509e-01, 4.8026e-02,
 2DIAGNOSTIC,     3, -6.156350374222e-01, inf, 5.7109e-01, 4.6004e-02,
 2DIAGNOSTIC,     4, -6.225771903992e-01, inf, 6.1958e-01, 4.8486e-02,
 2DIAGNOSTIC,     5, -6.322543025017e-01, inf, 6.6543e-01, 4.5851e-02,
 2DIAGNOSTIC,     6, -6.436683535576e-01, inf, 7.1363e-01, 4.8201e-02,
 2DIAGNOSTIC,     7, -6.545858979225e-01, inf, 7.6533e-01, 5.1699e-02,
 2DIAGNOSTIC,     8, -6.581582427025e-01, inf, 8.4298e-01, 7.7653e-02,
 2DIAGNOSTIC,     9, -6.601005792618e-01, inf, 8.8245e-01, 3.9467e-02,
 2DIAGNOSTIC,    10, -6.612322926521e-01, 6.406048778445e-03, 9.3268e-01, 5.0227e-02,
 2DIAGNOSTIC,    11, -6.624592542648e-01, 5.329694133252e-03, 9.8931e-01, 5.6630e-02,
 2DIAGNOSTIC,    12, -6.639032363892e-01, 4.129989538342e-03, 1.0461e+00, 5.6790e-02,
 2DIAGNOSTIC,    13, -6.723549365997e-01, 3.197609214112e-03, 1.0985e+00, 5.2432e-02,
 2DIAGNOSTIC,    14, -6.848542690277e-01, 2.715482143685e-03, 1.1460e+00, 4.7477e-02,
 2DIAGNOSTIC,    15, -6.966552138329e-01, 2.666580257937e-03, 1.1980e+00, 5.1975e-02,
 2DIAGNOSTIC,    16, -7.080930471420e-01, 2.990929177031e-03, 1.2496e+00, 5.1587e-02,
 2DIAGNOSTIC,    17, -7.209619879723e-01, 3.599152900279e-03, 1.3137e+00, 6.4164e-02,
 2DIAGNOSTIC,    18, -7.273271083832e-01, 4.032272379845e-03, 1.3602e+00, 4.6513e-02,
 2DIAGNOSTIC,    19, -7.353868484497e-01, 4.263578448445e-03, 1.4158e+00, 5.5593e-02,
 2DIAGNOSTIC,    20, -7.396211028099e-01, 4.185804631561e-03, 1.4656e+00, 4.9812e-02,
 2DIAGNOSTIC,    21, -7.407525181770e-01, 3.776704194024e-03, 1.5170e+00, 5.1394e-02,
 2DIAGNOSTIC,    22, -7.413460016251e-01, 3.095751162618e-03, 1.5664e+00, 4.9336e-02,
 2DIAGNOSTIC,    23, -7.418485283852e-01, 2.351543866098e-03, 1.6274e+00, 6.0981e-02,
 2DIAGNOSTIC,    24, -7.420701980591e-01, 1.673946972005e-03, 1.6813e+00, 5.3957e-02,
 2DIAGNOSTIC,    25, -7.424064278603e-01, 1.097827102058e-03, 1.7294e+00, 4.8067e-02,
 2DIAGNOSTIC,    26, -7.424998879433e-01, 6.475810660049e-04, 1.7682e+00, 3.8778e-02,
 2DIAGNOSTIC,    27, -7.425398826599e-01, 3.697811916936e-04, 1.8075e+00, 3.9335e-02,
 2DIAGNOSTIC,    28, -7.426826357841e-01, 1.719761494314e-04, 1.8551e+00, 4.7604e-02,
 2DIAGNOSTIC,    29, -7.427868843079e-01, 8.690298272995e-05, 1.8973e+00, 4.2244e-02,
 2DIAGNOSTIC,    30, -7.428846955299e-01, 5.867766230949e-05, 1.9725e+00, 7.5166e-02,
 2DIAGNOSTIC,    31, -7.428848147392e-01, 4.176667789579e-05, 2.0227e+00, 5.0149e-02,
 2DIAGNOSTIC,    32, -7.429132461548e-01, 3.000577089551e-05, 2.0733e+00, 5.0668e-02,
 2DIAGNOSTIC,    33, -7.429236769676e-01, 2.255803883600e-05, 2.1242e+00, 5.0890e-02,
 2DIAGNOSTIC,    34, -7.429249286652e-01, 1.607540980331e-05, 2.1709e+00, 4.6653e-02,
 2DIAGNOSTIC,    35, -7.429298162460e-01, 1.249422439287e-05, 2.2163e+00, 4.5385e-02,
 2DIAGNOSTIC,    36, -7.429354190826e-01, 9.164499715553e-06, 2.2613e+00, 4.5040e-02,
 2DIAGNOSTIC,    37, -7.429420351982e-01, 5.732518729928e-06, 2.3122e+00, 5.0917e-02,
 2DIAGNOSTIC,    38, -7.429513931274e-01, 3.626312945926e-06, 2.3561e+00, 4.3935e-02,
 2DIAGNOSTIC,    39, -7.429602742195e-01, 2.516700988053e-06, 2.4069e+00, 5.0796e-02,
 2DIAGNOSTIC,    40, -7.429607510567e-01, 2.300952473888e-06, 2.4756e+00, 6.8644e-02,
 2DIAGNOSTIC,    41, -7.429684400558e-01, 2.027850541708e-06, 2.5334e+00, 5.7846e-02,
 2DIAGNOSTIC,    42, -7.429695725441e-01, 1.931344058903e-06, 2.5949e+00, 6.1487e-02,
 2DIAGNOSTIC,    43, -7.429693341255e-01, 1.825929530241e-06, 2.6437e+00, 4.8824e-02,
 2DIAGNOSTIC,    44, -7.429692149162e-01, 1.635540115785e-06, 2.6998e+00, 5.6036e-02,
 2DIAGNOSTIC,    45, -7.429696321487e-01, 1.417493308509e-06, 2.7531e+00, 5.3369e-02,
 2DIAGNOSTIC,    46, -7.429659366608e-01, 1.160427586910e-06, 2.8080e+00, 5.4844e-02,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -6.466758251190e-01, inf, 3.5324e+00, 7.2443e-01,
 2DIAGNOSTIC,     2, -6.473460793495e-01, inf, 3.7315e+00, 1.9910e-01,
 2DIAGNOSTIC,     3, -6.476886272430e-01, inf, 3.9398e+00, 2.0831e-01,
 2DIAGNOSTIC,     4, -6.479256153107e-01, inf, 4.1818e+00, 2.4194e-01,
 2DIAGNOSTIC,     5, -6.480330824852e-01, inf, 4.4563e+00, 2.7453e-01,
 2DIAGNOSTIC,     6, -6.480953693390e-01, inf, 4.6840e+00, 2.2767e-01,
 2DIAGNOSTIC,     7, -6.481891274452e-01, inf, 4.9217e+00, 2.3776e-01,
 2DIAGNOSTIC,     8, -6.483259201050e-01, inf, 5.2670e+00, 3.4532e-01,
 2DIAGNOSTIC,     9, -6.483272910118e-01, inf, 5.4809e+00, 2.1383e-01,
 2DIAGNOSTIC,    10, -6.483662724495e-01, 1.404139766237e-04, 5.7103e+00, 2.2939e-01,
 2DIAGNOSTIC,    11, -6.483827233315e-01, 8.515053195879e-05, 5.9716e+00, 2.6133e-01,
 2DIAGNOSTIC,    12, -6.483860611916e-01, 5.607376078842e-05, 6.2194e+00, 2.4784e-01,
 2DIAGNOSTIC,    13, -6.483881473541e-01, 3.806052700384e-05, 6.4291e+00, 2.0968e-01,
 2DIAGNOSTIC,    14, -6.483911871910e-01, 2.686799962248e-05, 6.7204e+00, 2.9124e-01,
 2DIAGNOSTIC,    15, -6.483904123306e-01, 1.806733052945e-05, 6.9694e+00, 2.4900e-01,
 2DIAGNOSTIC,    16, -6.483910083771e-01, 1.059131864167e-05, 7.2512e+00, 2.8181e-01,
 2DIAGNOSTIC,    17, -6.483908891678e-01, 5.531784154300e-06, 7.5475e+00, 2.9633e-01,
 2DIAGNOSTIC,    18, -6.483910679817e-01, 4.049027211295e-06, 7.7847e+00, 2.3722e-01,
 2DIAGNOSTIC,    19, -6.483911275864e-01, 2.522861677789e-06, 8.0803e+00, 2.9561e-01,
 2DIAGNOSTIC,    20, -6.483912467957e-01, 1.919092710523e-06, 8.3203e+00, 2.3993e-01,
 2DIAGNOSTIC,    21, -6.483910679817e-01, 1.681488924987e-06, 8.5992e+00, 2.7897e-01,
 2DIAGNOSTIC,    22, -6.483910083771e-01, 1.514734663033e-06, 8.8441e+00, 2.4485e-01,
 2DIAGNOSTIC,    23, -6.483907699585e-01, 1.389639237459e-06, 9.0530e+00, 2.0890e-01,
 2DIAGNOSTIC,    24, -6.483907103539e-01, 1.329365204583e-06, 9.3401e+00, 2.8710e-01,
 2DIAGNOSTIC,    25, -6.483908891678e-01, 1.262790306100e-06, 9.6210e+00, 2.8089e-01,
 2DIAGNOSTIC,    26, -6.483910083771e-01, 1.214333792632e-06, 9.8954e+00, 2.7439e-01,
 2DIAGNOSTIC,    27, -6.483909487724e-01, 1.167422738035e-06, 1.0124e+01, 2.2856e-01,
 2DIAGNOSTIC,    28, -6.483908891678e-01, 1.126887923419e-06, 1.0357e+01, 2.3306e-01,
 2DIAGNOSTIC,    29, -6.483906507492e-01, 1.087306145564e-06, 1.0587e+01, 2.3012e-01,
 2DIAGNOSTIC,    30, -6.483907699585e-01, 1.054817289514e-06, 1.0831e+01, 2.4403e-01,
 2DIAGNOSTIC,    31, -6.483905911446e-01, 1.019746946440e-06, 1.1041e+01, 2.0941e-01,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -5.343053340912e-01, inf, 1.1864e+01, 8.2364e-01,
 2DIAGNOSTIC,     2, -5.344599485397e-01, inf, 1.2089e+01, 2.2473e-01,
 2DIAGNOSTIC,     3, -5.346873402596e-01, inf, 1.2400e+01, 3.1111e-01,
 2DIAGNOSTIC,     4, -5.347176194191e-01, inf, 1.2611e+01, 2.1067e-01,
 2DIAGNOSTIC,     5, -5.347980856895e-01, inf, 1.2832e+01, 2.2099e-01,
 2DIAGNOSTIC,     6, -5.348170995712e-01, inf, 1.3049e+01, 2.1736e-01,
 2DIAGNOSTIC,     7, -5.348311662674e-01, inf, 1.3282e+01, 2.3259e-01,
 2DIAGNOSTIC,     8, -5.348387360573e-01, inf, 1.3520e+01, 2.3878e-01,
 2DIAGNOSTIC,     9, -5.348448157310e-01, inf, 1.3747e+01, 2.2624e-01,
 2DIAGNOSTIC,    10, -5.348503589630e-01, 5.865432467544e-05, 1.3989e+01, 2.4221e-01,
 2DIAGNOSTIC,    11, -5.348543524742e-01, 3.417522384552e-05, 1.4205e+01, 2.1583e-01,
 2DIAGNOSTIC,    12, -5.348599553108e-01, 1.784097003110e-05, 1.4407e+01, 2.0236e-01,
 2DIAGNOSTIC,    13, -5.348683595657e-01, 1.229650661116e-05, 1.4661e+01, 2.5386e-01,
 2DIAGNOSTIC,    14, -5.348743200302e-01, 7.945391189423e-06, 1.4902e+01, 2.4141e-01,
 2DIAGNOSTIC,    15, -5.348783135414e-01, 6.636347734457e-06, 1.5116e+01, 2.1346e-01,
 2DIAGNOSTIC,    16, -5.348829030991e-01, 5.853358288732e-06, 1.5323e+01, 2.0681e-01,
 2DIAGNOSTIC,    17, -5.348891019821e-01, 5.434590093500e-06, 1.5614e+01, 2.9116e-01,
 2DIAGNOSTIC,    18, -5.348933339119e-01, 5.073240117781e-06, 1.5817e+01, 2.0344e-01,
 2DIAGNOSTIC,    19, -5.348966121674e-01, 4.701485977421e-06, 1.6066e+01, 2.4923e-01,
 2DIAGNOSTIC,    20, -5.348986387253e-01, 4.287875526643e-06, 1.6267e+01, 2.0034e-01,
 2DIAGNOSTIC,    21, -5.349030494690e-01, 3.874392405123e-06, 1.6537e+01, 2.7050e-01,
 2DIAGNOSTIC,    22, -5.349045395851e-01, 3.442542947596e-06, 1.6743e+01, 2.0567e-01,
 2DIAGNOSTIC,    23, -5.349085330963e-01, 3.145342134303e-06, 1.6987e+01, 2.4428e-01,
 2DIAGNOSTIC,    24, -5.349091887474e-01, 2.852877969417e-06, 1.7211e+01, 2.2348e-01,
 2DIAGNOSTIC,    25, -5.349137187004e-01, 2.621635076139e-06, 1.7449e+01, 2.3834e-01,
 2DIAGNOSTIC,    26, -5.349149107933e-01, 2.395028786850e-06, 1.7685e+01, 2.3601e-01,
 2DIAGNOSTIC,    27, -5.349177122116e-01, 2.250552142868e-06, 1.7922e+01, 2.3700e-01,
 2DIAGNOSTIC,    28, -5.349204540253e-01, 2.146381348211e-06, 1.8165e+01, 2.4263e-01,
 2DIAGNOSTIC,    29, -5.349376201630e-01, 2.327709580641e-06, 1.8462e+01, 2.9761e-01,
 2DIAGNOSTIC,    30, -5.349223017693e-01, 2.135612476195e-06, 1.8710e+01, 2.4794e-01,
 2DIAGNOSTIC,    31, -5.349230170250e-01, 1.953286982825e-06, 1.8953e+01, 2.4253e-01,
 2DIAGNOSTIC,    32, -5.349407196045e-01, 2.012885715885e-06, 1.9222e+01, 2.6911e-01,
 2DIAGNOSTIC,    33, -5.349408984184e-01, 2.026337597272e-06, 1.9431e+01, 2.0868e-01,
 2DIAGNOSTIC,    34, -5.349408984184e-01, 1.946957809196e-06, 1.9664e+01, 2.3354e-01,
 2DIAGNOSTIC,    35, -5.349413752556e-01, 1.860030693024e-06, 1.9903e+01, 2.3872e-01,
 2DIAGNOSTIC,    36, -5.349415540695e-01, 1.710692913548e-06, 2.0139e+01, 2.3615e-01,
 2DIAGNOSTIC,    37, -5.349417924881e-01, 1.528313191557e-06, 2.0370e+01, 2.3143e-01,
 2DIAGNOSTIC,    38, -5.349426865578e-01, 1.332478291260e-06, 2.0583e+01, 2.1293e-01,
 2DIAGNOSTIC,    39, -5.349428057671e-01, 1.344734187114e-06, 2.0842e+01, 2.5850e-01,
 2DIAGNOSTIC,    40, -5.349432229996e-01, 1.110613652600e-06, 2.1100e+01, 2.5781e-01,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -4.252259135246e-01, inf, 2.3524e+01, 2.4248e+00,
  Elapsed time (stage 0): 2.4516e+01

Stage 1
  iterations = 0x0x0x0
  convergence threshold = 1.0000e-07
  convergence window size = 8
  number of levels = 4
  using the Mattes MI metric (number of bins = 32, weight = 1.0000e+00)
  preprocessing:  histogram matching the images
  Shrink factors (level 1 out of 4): [8, 8, 8]
  Shrink factors (level 2 out of 4): [4, 4, 4]
  Shrink factors (level 3 out of 4): [2, 2, 2]
  Shrink factors (level 4 out of 4): [1, 1, 1]
  smoothing sigmas per level: [3, 2, 1, 0]
  Using default NONE metricSamplingStrategy

*** Running SyN registration (varianceForUpdateField = 3.0000e+00, varianceForTotalField = 0.0000e+00) ***

  Elapsed time (stage 1): 4.3329e+00

Total elapsed time: 2.8882e+01
0.0
All_Command_lines_OK
Using single precision for computations.
=============================================================================
The composite transform comprises the following transforms (in order):
  1. Center of mass alignment using fixed image: 0x11605cd0 and moving image: 0x1131c470 (type = Euler3DTransform)
=============================================================================
  Reading mask(s).
    Registration stage 0
      No fixed mask
      No moving mask
    Registration stage 1
      No fixed mask
      No moving mask
  number of levels = 4
  number of levels = 4
  fixed image: 0x11605cd0
  moving image: 0x1131c470
  fixed image: 0x11605cd0
  moving image: 0x1131c470
Dimension = 3
Number of stages = 2
Use Histogram Matching true
Winsorize image intensities false
Lower quantile = 0.0000e+00
Upper quantile = 1.0000e+00
Stage 1 State
   Image metric = Mattes
     Fixed image = Image (0x127e0600)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 10997235
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 10997209
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [9.0212e+01, 8.9871e+01, -1.3853e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x10dd5560)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 10997207
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff7756bf010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Moving image = Image (0x127bc560)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 10997236
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 10997233
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [9.0212e+01, 8.9871e+01, -1.3853e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x11d4b6a0)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 10997231
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff7696bf010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Weighting = 1.0000e+00
     Sampling strategy = regular
     Number of bins = 32
     Radius = 4
     Sampling percentage  = 2.0000e-01
   Transform = Affine
     Gradient step = 2.5000e-01
     Update field sigma (voxel space) = 0.0000e+00
     Total field sigma (voxel space) = 0.0000e+00
     Update field time sigma = 0.0000e+00
     Total field time sigma  = 0.0000e+00
     Number of time indices = 0
     Number of time point samples = 0
Stage 2 State
   Image metric = Mattes
     Fixed image = Image (0x127f4f20)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 10997285
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 10997259
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [9.0212e+01, 8.9871e+01, -1.3853e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x1253f1e0)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 10997257
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff7616bf010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Moving image = Image (0x127e0fe0)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 10997286
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 10997283
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [9.0212e+01, 8.9871e+01, -1.3853e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x11815090)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 10997281
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff7496bf010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Weighting = 1.0000e+00
     Sampling strategy = none
     Number of bins = 32
     Radius = 4
     Sampling percentage  = 1.0000e+00
   Transform = SyN
     Gradient step = 2.0000e-01
     Update field sigma (voxel space) = 3.0000e+00
     Total field sigma (voxel space) = 0.0000e+00
     Update field time sigma = 0.0000e+00
     Total field time sigma  = 0.0000e+00
     Number of time indices = 0
     Number of time point samples = 0
Registration using 2 total stages.

Stage 0
  iterations = 2100x1200x1200x0
  convergence threshold = 1.0000e-06
  convergence window size = 10
  number of levels = 4
  using the Mattes MI metric (number of bins = 32, weight = 1.0000e+00)
  preprocessing:  histogram matching the images
  Shrink factors (level 1 out of 4): [4, 4, 4]
  Shrink factors (level 2 out of 4): [2, 2, 2]
  Shrink factors (level 3 out of 4): [2, 2, 2]
  Shrink factors (level 4 out of 4): [1, 1, 1]
  smoothing sigmas per level: [3, 2, 1, 0]
  regular sampling (percentage = 2.0000e-01)

*** Running AffineTransform registration ***

DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -9.921001195908e-01, inf, 4.4488e-01, 4.4488e-01,
 2DIAGNOSTIC,     2, -1.010827660561e+00, inf, 4.9055e-01, 4.5666e-02,
 2DIAGNOSTIC,     3, -1.034385800362e+00, inf, 5.3834e-01, 4.7797e-02,
 2DIAGNOSTIC,     4, -1.053313970566e+00, inf, 5.8314e-01, 4.4797e-02,
 2DIAGNOSTIC,     5, -1.060212135315e+00, inf, 6.2992e-01, 4.6779e-02,
 2DIAGNOSTIC,     6, -1.063987135887e+00, inf, 6.8060e-01, 5.0681e-02,
 2DIAGNOSTIC,     7, -1.067303895950e+00, inf, 7.4895e-01, 6.8352e-02,
 2DIAGNOSTIC,     8, -1.067623138428e+00, inf, 7.9395e-01, 4.5000e-02,
 2DIAGNOSTIC,     9, -1.069220304489e+00, inf, 8.3909e-01, 4.5134e-02,
 2DIAGNOSTIC,    10, -1.070279479027e+00, 4.329852294177e-03, 8.8557e-01, 4.6488e-02,
 2DIAGNOSTIC,    11, -1.071287035942e+00, 2.633249387145e-03, 9.3825e-01, 5.2673e-02,
 2DIAGNOSTIC,    12, -1.071576714516e+00, 1.407886040397e-03, 1.0038e+00, 6.5591e-02,
 2DIAGNOSTIC,    13, -1.072053313255e+00, 7.375923451036e-04, 1.0519e+00, 4.8064e-02,
 2DIAGNOSTIC,    14, -1.072348117828e+00, 4.652189672925e-04, 1.1016e+00, 4.9656e-02,
 2DIAGNOSTIC,    15, -1.072565674782e+00, 3.134954022244e-04, 1.1467e+00, 4.5127e-02,
 2DIAGNOSTIC,    16, -1.073142528534e+00, 2.241855690954e-04, 1.1976e+00, 5.0920e-02,
 2DIAGNOSTIC,    17, -1.074517011642e+00, 1.992909528781e-04, 1.2503e+00, 5.2654e-02,
 2DIAGNOSTIC,    18, -1.074738979340e+00, 1.662153517827e-04, 1.3066e+00, 5.6329e-02,
 2DIAGNOSTIC,    19, -1.074701547623e+00, 1.434267323930e-04, 1.3522e+00, 4.5626e-02,
 2DIAGNOSTIC,    20, -1.074765443802e+00, 1.248467888217e-04, 1.3984e+00, 4.6172e-02,
 2DIAGNOSTIC,    21, -1.074823975563e+00, 1.100196022890e-04, 1.4506e+00, 5.2214e-02,
 2DIAGNOSTIC,    22, -1.074846506119e+00, 8.981264545582e-05, 1.5031e+00, 5.2488e-02,
 2DIAGNOSTIC,    23, -1.074867606163e+00, 6.885944458190e-05, 1.5662e+00, 6.3083e-02,
 2DIAGNOSTIC,    24, -1.074890971184e+00, 4.715339309769e-05, 1.6292e+00, 6.3016e-02,
 2DIAGNOSTIC,    25, -1.074869155884e+00, 2.501972267055e-05, 1.6823e+00, 5.3084e-02,
 2DIAGNOSTIC,    26, -1.074871659279e+00, 7.940746399981e-06, 1.7278e+00, 4.5547e-02,
 2DIAGNOSTIC,    27, -1.074861526489e+00, 4.934111075272e-06, 1.7797e+00, 5.1838e-02,
 2DIAGNOSTIC,    28, -1.074865818024e+00, 3.968899363826e-06, 1.8238e+00, 4.4137e-02,
 2DIAGNOSTIC,    29, -1.074859976768e+00, 2.393850763838e-06, 1.8748e+00, 5.1011e-02,
 2DIAGNOSTIC,    30, -1.074868321419e+00, 1.438695790057e-06, 1.9264e+00, 5.1561e-02,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -9.696810841560e-01, inf, 2.6688e+00, 7.4246e-01,
 2DIAGNOSTIC,     2, -9.705455303192e-01, inf, 2.8657e+00, 1.9685e-01,
 2DIAGNOSTIC,     3, -9.711368083954e-01, inf, 3.0734e+00, 2.0770e-01,
 2DIAGNOSTIC,     4, -9.725028276443e-01, inf, 3.2999e+00, 2.2655e-01,
 2DIAGNOSTIC,     5, -9.728791117668e-01, inf, 3.5693e+00, 2.6935e-01,
 2DIAGNOSTIC,     6, -9.729751944542e-01, inf, 3.7843e+00, 2.1503e-01,
 2DIAGNOSTIC,     7, -9.730424880981e-01, inf, 3.9798e+00, 1.9552e-01,
 2DIAGNOSTIC,     8, -9.731811285019e-01, inf, 4.1697e+00, 1.8990e-01,
 2DIAGNOSTIC,     9, -9.734491705894e-01, inf, 4.4022e+00, 2.3246e-01,
 2DIAGNOSTIC,    10, -9.738471508026e-01, 2.488867030479e-04, 4.7030e+00, 3.0080e-01,
 2DIAGNOSTIC,    11, -9.738681316376e-01, 1.757723366609e-04, 4.9436e+00, 2.4062e-01,
 2DIAGNOSTIC,    12, -9.738774895668e-01, 1.209365000250e-04, 5.1346e+00, 1.9099e-01,
 2DIAGNOSTIC,    13, -9.738815426826e-01, 7.657056994503e-05, 5.3626e+00, 2.2803e-01,
 2DIAGNOSTIC,    14, -9.738876223564e-01, 6.014502287144e-05, 5.5862e+00, 2.2357e-01,
 2DIAGNOSTIC,    15, -9.738867282867e-01, 4.779511800734e-05, 5.8149e+00, 2.2874e-01,
 2DIAGNOSTIC,    16, -9.738865494728e-01, 3.459724393906e-05, 6.0678e+00, 2.5289e-01,
 2DIAGNOSTIC,    17, -9.738871455193e-01, 2.121441320924e-05, 6.3247e+00, 2.5691e-01,
 2DIAGNOSTIC,    18, -9.738866686821e-01, 9.731309546623e-06, 6.5837e+00, 2.5896e-01,
 2DIAGNOSTIC,    19, -9.738867878914e-01, 2.671756192285e-06, 6.8446e+00, 2.6089e-01,
 2DIAGNOSTIC,    20, -9.738867282867e-01, 2.030849145740e-06, 7.0479e+00, 2.0327e-01,
 2DIAGNOSTIC,    21, -9.738857150078e-01, 1.686142582003e-06, 7.2771e+00, 2.2928e-01,
 2DIAGNOSTIC,    22, -9.738860726357e-01, 1.485410734858e-06, 7.5010e+00, 2.2381e-01,
 2DIAGNOSTIC,    23, -9.738863706589e-01, 1.351178980258e-06, 7.7256e+00, 2.2466e-01,
 2DIAGNOSTIC,    24, -9.738875627518e-01, 1.319850298387e-06, 7.9625e+00, 2.3693e-01,
 2DIAGNOSTIC,    25, -9.738872051239e-01, 1.276830744246e-06, 8.1919e+00, 2.2934e-01,
 2DIAGNOSTIC,    26, -9.738875031471e-01, 1.238396407643e-06, 8.3901e+00, 1.9820e-01,
 2DIAGNOSTIC,    27, -9.738878011703e-01, 1.211332460116e-06, 8.6160e+00, 2.2596e-01,
 2DIAGNOSTIC,    28, -9.738879799843e-01, 1.179589844469e-06, 8.8463e+00, 2.3027e-01,
 2DIAGNOSTIC,    29, -9.738882780075e-01, 1.149976355919e-06, 9.0747e+00, 2.2839e-01,
 2DIAGNOSTIC,    30, -9.738890528679e-01, 1.124699565480e-06, 9.3080e+00, 2.3329e-01,
 2DIAGNOSTIC,    31, -9.738895893097e-01, 1.090451405616e-06, 9.5289e+00, 2.2086e-01,
 2DIAGNOSTIC,    32, -9.738882184029e-01, 1.042982603394e-06, 9.7337e+00, 2.0480e-01,
 2DIAGNOSTIC,    33, -9.738890528679e-01, 1.003990632853e-06, 9.9453e+00, 2.1165e-01,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -8.622311353683e-01, inf, 1.0732e+01, 7.8654e-01,
 2DIAGNOSTIC,     2, -8.649071455002e-01, inf, 1.0943e+01, 2.1130e-01,
 2DIAGNOSTIC,     3, -8.664579987526e-01, inf, 1.1195e+01, 2.5138e-01,
 2DIAGNOSTIC,     4, -8.672237992287e-01, inf, 1.1417e+01, 2.2270e-01,
 2DIAGNOSTIC,     5, -8.689579963684e-01, inf, 1.1650e+01, 2.3291e-01,
 2DIAGNOSTIC,     6, -8.700103163719e-01, inf, 1.1852e+01, 2.0220e-01,
 2DIAGNOSTIC,     7, -8.703308105469e-01, inf, 1.2106e+01, 2.5367e-01,
 2DIAGNOSTIC,     8, -8.705009818077e-01, inf, 1.2311e+01, 2.0487e-01,
 2DIAGNOSTIC,     9, -8.706887960434e-01, inf, 1.2589e+01, 2.7805e-01,
 2DIAGNOSTIC,    10, -8.707395195961e-01, 5.931453779340e-04, 1.2826e+01, 2.3698e-01,
 2DIAGNOSTIC,    11, -8.707803487778e-01, 3.843018785119e-04, 1.3066e+01, 2.3964e-01,
 2DIAGNOSTIC,    12, -8.708009123802e-01, 2.492914209142e-04, 1.3301e+01, 2.3533e-01,
 2DIAGNOSTIC,    13, -8.708105087280e-01, 1.524051476736e-04, 1.3520e+01, 2.1953e-01,
 2DIAGNOSTIC,    14, -8.708108663559e-01, 7.284919411177e-05, 1.3754e+01, 2.3325e-01,
 2DIAGNOSTIC,    15, -8.708109259605e-01, 3.474903132883e-05, 1.3979e+01, 2.2550e-01,
 2DIAGNOSTIC,    16, -8.708117008209e-01, 1.985117705772e-05, 1.4201e+01, 2.2162e-01,
 2DIAGNOSTIC,    17, -8.708077073097e-01, 1.110719676944e-05, 1.4437e+01, 2.3608e-01,
 2DIAGNOSTIC,    18, -8.708057403564e-01, 5.461763521453e-06, 1.4662e+01, 2.2467e-01,
 2DIAGNOSTIC,    19, -8.708061575890e-01, 3.296780505480e-06, 1.4903e+01, 2.4142e-01,
 2DIAGNOSTIC,    20, -8.708015680313e-01, 1.937823526532e-06, 1.5133e+01, 2.3050e-01,
 2DIAGNOSTIC,    21, -8.708046078682e-01, 1.353474317511e-06, 1.5379e+01, 2.4511e-01,
 2DIAGNOSTIC,    22, -8.708140254021e-01, 1.278002287108e-06, 1.5616e+01, 2.3731e-01,
 2DIAGNOSTIC,    23, -8.708151578903e-01, 1.373774011881e-06, 1.5837e+01, 2.2159e-01,
 2DIAGNOSTIC,    24, -8.708204030991e-01, 1.540112521070e-06, 1.6072e+01, 2.3451e-01,
 2DIAGNOSTIC,    25, -8.708254694939e-01, 1.739847562021e-06, 1.6323e+01, 2.5153e-01,
 2DIAGNOSTIC,    26, -8.708239197731e-01, 1.870203732324e-06, 1.6586e+01, 2.6201e-01,
 2DIAGNOSTIC,    27, -8.708234429359e-01, 1.876049736893e-06, 1.6831e+01, 2.4564e-01,
 2DIAGNOSTIC,    28, -8.708227872849e-01, 1.785006816135e-06, 1.7092e+01, 2.6056e-01,
 2DIAGNOSTIC,    29, -8.708221316338e-01, 1.638623871258e-06, 1.7348e+01, 2.5604e-01,
 2DIAGNOSTIC,    30, -8.708207607269e-01, 1.385428504364e-06, 1.7626e+01, 2.7866e-01,
 2DIAGNOSTIC,    31, -8.708195090294e-01, 1.135267439167e-06, 1.7901e+01, 2.7423e-01,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -7.619358897209e-01, inf, 2.0443e+01, 2.5426e+00,
  Elapsed time (stage 0): 2.1435e+01

Stage 1
  iterations = 0x0x0x0
  convergence threshold = 1.0000e-07
  convergence window size = 8
  number of levels = 4
  using the Mattes MI metric (number of bins = 32, weight = 1.0000e+00)
  preprocessing:  histogram matching the images
  Shrink factors (level 1 out of 4): [8, 8, 8]
  Shrink factors (level 2 out of 4): [4, 4, 4]
  Shrink factors (level 3 out of 4): [2, 2, 2]
  Shrink factors (level 4 out of 4): [1, 1, 1]
  smoothing sigmas per level: [3, 2, 1, 0]
  Using default NONE metricSamplingStrategy

*** Running SyN registration (varianceForUpdateField = 3.0000e+00, varianceForTotalField = 0.0000e+00) ***

  Elapsed time (stage 1): 4.6469e+00

Total elapsed time: 2.6127e+01
All_Command_lines_OK
Using single precision for computations.
=============================================================================
The composite transform comprises the following transforms (in order):
  1. Center of mass alignment using fixed image: 0x123a2660 and moving image: 0x10f8b0d0 (type = Euler3DTransform)
=============================================================================
  Reading mask(s).
    Registration stage 0
      No fixed mask
      No moving mask
    Registration stage 1
      No fixed mask
      No moving mask
  number of levels = 4
  number of levels = 4
  fixed image: 0x123a2660
  moving image: 0x10f8b0d0
  fixed image: 0x123a2660
  moving image: 0x10f8b0d0
Dimension = 3
Number of stages = 2
Use Histogram Matching true
Winsorize image intensities false
Lower quantile = 0.0000e+00
Upper quantile = 1.0000e+00
Stage 1 State
   Image metric = Mattes
     Fixed image = Image (0x127f3aa0)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 16492921
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 16492895
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [9.0212e+01, 8.9871e+01, -1.3853e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x10403a40)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 16492893
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff77043d010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Moving image = Image (0x128051a0)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 16492922
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 16492919
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [8.6557e+01, 8.7864e+01, -1.4492e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x118db210)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 16492917
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff7696bf010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Weighting = 1.0000e+00
     Sampling strategy = regular
     Number of bins = 32
     Radius = 4
     Sampling percentage  = 2.0000e-01
   Transform = Affine
     Gradient step = 2.5000e-01
     Update field sigma (voxel space) = 0.0000e+00
     Total field sigma (voxel space) = 0.0000e+00
     Update field time sigma = 0.0000e+00
     Total field time sigma  = 0.0000e+00
     Number of time indices = 0
     Number of time point samples = 0
Stage 2 State
   Image metric = Mattes
     Fixed image = Image (0x12805460)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 16492971
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 16492945
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [9.0212e+01, 8.9871e+01, -1.3853e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x11a29c20)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 16492943
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff7616bf010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Moving image = Image (0x127ab210)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 16492972
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 16492969
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [8.6557e+01, 8.7864e+01, -1.4492e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x11293f00)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 16492967
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff756d7e010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Weighting = 1.0000e+00
     Sampling strategy = none
     Number of bins = 32
     Radius = 4
     Sampling percentage  = 1.0000e+00
   Transform = SyN
     Gradient step = 2.0000e-01
     Update field sigma (voxel space) = 3.0000e+00
     Total field sigma (voxel space) = 0.0000e+00
     Update field time sigma = 0.0000e+00
     Total field time sigma  = 0.0000e+00
     Number of time indices = 0
     Number of time point samples = 0
Registration using 2 total stages.

Stage 0
  iterations = 2100x1200x1200x0
  convergence threshold = 1.0000e-06
  convergence window size = 10
  number of levels = 4
  using the Mattes MI metric (number of bins = 32, weight = 1.0000e+00)
  preprocessing:  histogram matching the images
  Shrink factors (level 1 out of 4): [4, 4, 4]
  Shrink factors (level 2 out of 4): [2, 2, 2]
  Shrink factors (level 3 out of 4): [2, 2, 2]
  Shrink factors (level 4 out of 4): [1, 1, 1]
  smoothing sigmas per level: [3, 2, 1, 0]
  regular sampling (percentage = 2.0000e-01)

*** Running AffineTransform registration ***

DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -6.111307144165e-01, inf, 4.4909e-01, 4.4909e-01,
 2DIAGNOSTIC,     2, -6.158673167229e-01, inf, 4.9179e-01, 4.2696e-02,
 2DIAGNOSTIC,     3, -6.243329644203e-01, inf, 5.3364e-01, 4.1857e-02,
 2DIAGNOSTIC,     4, -6.397279500961e-01, inf, 5.7863e-01, 4.4985e-02,
 2DIAGNOSTIC,     5, -6.683725714684e-01, inf, 6.2200e-01, 4.3374e-02,
 2DIAGNOSTIC,     6, -7.157925963402e-01, inf, 6.7549e-01, 5.3490e-02,
 2DIAGNOSTIC,     7, -7.528628110886e-01, inf, 7.4601e-01, 7.0521e-02,
 2DIAGNOSTIC,     8, -7.552186250687e-01, inf, 7.8720e-01, 4.1186e-02,
 2DIAGNOSTIC,     9, -7.626263499260e-01, inf, 8.3258e-01, 4.5384e-02,
 2DIAGNOSTIC,    10, -7.732275128365e-01, 1.819375529885e-02, 8.7224e-01, 3.9662e-02,
 2DIAGNOSTIC,    11, -7.838282585144e-01, 1.590493693948e-02, 9.1172e-01, 3.9477e-02,
 2DIAGNOSTIC,    12, -7.970074415207e-01, 1.319128926843e-02, 9.4828e-01, 3.6557e-02,
 2DIAGNOSTIC,    13, -8.201109170914e-01, 1.071393396705e-02, 9.8594e-01, 3.7666e-02,
 2DIAGNOSTIC,    14, -8.733832240105e-01, 9.544573724270e-03, 1.0584e+00, 7.2423e-02,
 2DIAGNOSTIC,    15, -8.805198669434e-01, 8.558216504753e-03, 1.1066e+00, 4.8244e-02,
 2DIAGNOSTIC,    16, -8.879076242447e-01, 8.231086656451e-03, 1.1545e+00, 4.7857e-02,
 2DIAGNOSTIC,    17, -9.113492965698e-01, 8.535698987544e-03, 1.2206e+00, 6.6146e-02,
 2DIAGNOSTIC,    18, -9.144586324692e-01, 8.110398426652e-03, 1.2672e+00, 4.6565e-02,
 2DIAGNOSTIC,    19, -9.177466630936e-01, 7.186619564891e-03, 1.3165e+00, 4.9291e-02,
 2DIAGNOSTIC,    20, -9.197039604187e-01, 5.941393785179e-03, 1.3636e+00, 4.7172e-02,
 2DIAGNOSTIC,    21, -9.218327999115e-01, 4.513705149293e-03, 1.4256e+00, 6.1966e-02,
 2DIAGNOSTIC,    22, -9.228989481926e-01, 3.044982440770e-03, 1.4712e+00, 4.5598e-02,
 2DIAGNOSTIC,    23, -9.237728118896e-01, 1.788962981664e-03, 1.5202e+00, 4.9011e-02,
 2DIAGNOSTIC,    24, -9.247871041298e-01, 1.288389903493e-03, 1.5764e+00, 5.6149e-02,
 2DIAGNOSTIC,    25, -9.265539050102e-01, 8.392965537496e-04, 1.6302e+00, 5.3866e-02,
 2DIAGNOSTIC,    26, -9.275838136673e-01, 4.553618491627e-04, 1.6782e+00, 4.7973e-02,
 2DIAGNOSTIC,    27, -9.280757904053e-01, 3.683996328618e-04, 1.7525e+00, 7.4291e-02,
 2DIAGNOSTIC,    28, -9.283108711243e-01, 2.948735782411e-04, 1.7972e+00, 4.4737e-02,
 2DIAGNOSTIC,    29, -9.286460876465e-01, 2.421340032015e-04, 1.8478e+00, 5.0555e-02,
 2DIAGNOSTIC,    30, -9.287793636322e-01, 1.937185297720e-04, 1.8947e+00, 4.6932e-02,
 2DIAGNOSTIC,    31, -9.288131594658e-01, 1.541624369565e-04, 1.9415e+00, 4.6820e-02,
 2DIAGNOSTIC,    32, -9.288830757141e-01, 1.150748721557e-04, 1.9872e+00, 4.5703e-02,
 2DIAGNOSTIC,    33, -9.290416836739e-01, 7.846667722333e-05, 2.0360e+00, 4.8722e-02,
 2DIAGNOSTIC,    34, -9.291083216667e-01, 4.725093094748e-05, 2.0897e+00, 5.3698e-02,
 2DIAGNOSTIC,    35, -9.291182756424e-01, 3.050607301702e-05, 2.1354e+00, 4.5689e-02,
 2DIAGNOSTIC,    36, -9.291383624077e-01, 2.174392284360e-05, 2.1852e+00, 4.9801e-02,
 2DIAGNOSTIC,    37, -9.291371703148e-01, 1.595607682248e-05, 2.2368e+00, 5.1609e-02,
 2DIAGNOSTIC,    38, -9.292113780975e-01, 1.170466202893e-05, 2.3154e+00, 7.8672e-02,
 2DIAGNOSTIC,    39, -9.292299747467e-01, 9.639453310228e-06, 2.3708e+00, 5.5332e-02,
 2DIAGNOSTIC,    40, -9.292500615120e-01, 8.148406777764e-06, 2.4229e+00, 5.2131e-02,
 2DIAGNOSTIC,    41, -9.292502403259e-01, 6.329751613521e-06, 2.4705e+00, 4.7648e-02,
 2DIAGNOSTIC,    42, -9.292311072350e-01, 4.455831003725e-06, 2.5190e+00, 4.8411e-02,
 2DIAGNOSTIC,    43, -9.292406439781e-01, 3.607609187384e-06, 2.5662e+00, 4.7269e-02,
 2DIAGNOSTIC,    44, -9.292395710945e-01, 3.015570655407e-06, 2.6112e+00, 4.4951e-02,
 2DIAGNOSTIC,    45, -9.292410016060e-01, 2.322102091057e-06, 2.6563e+00, 4.5143e-02,
 2DIAGNOSTIC,    46, -9.292456507683e-01, 1.698296614450e-06, 2.7008e+00, 4.4467e-02,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -8.260408639908e-01, inf, 3.4319e+00, 7.3113e-01,
 2DIAGNOSTIC,     2, -8.276818394661e-01, inf, 3.6378e+00, 2.0589e-01,
 2DIAGNOSTIC,     3, -8.284384608269e-01, inf, 3.8414e+00, 2.0359e-01,
 2DIAGNOSTIC,     4, -8.297005295753e-01, inf, 4.1529e+00, 3.1153e-01,
 2DIAGNOSTIC,     5, -8.299532532692e-01, inf, 4.3515e+00, 1.9862e-01,
 2DIAGNOSTIC,     6, -8.301917314529e-01, inf, 4.5853e+00, 2.3377e-01,
 2DIAGNOSTIC,     7, -8.304347991943e-01, inf, 4.9373e+00, 3.5198e-01,
 2DIAGNOSTIC,     8, -8.304843306541e-01, inf, 5.1717e+00, 2.3440e-01,
 2DIAGNOSTIC,     9, -8.305025696754e-01, inf, 5.3874e+00, 2.1568e-01,
 2DIAGNOSTIC,    10, -8.305048346519e-01, 3.029136278201e-04, 5.6196e+00, 2.3225e-01,
 2DIAGNOSTIC,    11, -8.304992914200e-01, 1.733925746521e-04, 5.8230e+00, 2.0334e-01,
 2DIAGNOSTIC,    12, -8.304997086525e-01, 9.685620898381e-05, 6.0473e+00, 2.2432e-01,
 2DIAGNOSTIC,    13, -8.305017948151e-01, 4.277474363334e-05, 6.2601e+00, 2.1275e-01,
 2DIAGNOSTIC,    14, -8.304948806763e-01, 2.344859967707e-05, 6.4815e+00, 2.2148e-01,
 2DIAGNOSTIC,    15, -8.304793834686e-01, 1.011808762996e-05, 6.6868e+00, 2.0531e-01,
 2DIAGNOSTIC,    16, -8.304967880249e-01, 3.079725274802e-06, 6.8969e+00, 2.1011e-01,
 2DIAGNOSTIC,    17, -8.305186033249e-01, 2.066698016279e-06, 7.0937e+00, 1.9675e-01,
 2DIAGNOSTIC,    18, -8.305715322495e-01, 3.073711013712e-06, 7.3531e+00, 2.5935e-01,
 2DIAGNOSTIC,    19, -8.305709362030e-01, 4.155026545050e-06, 7.5542e+00, 2.0115e-01,
 2DIAGNOSTIC,    20, -8.305677771568e-01, 4.906904450763e-06, 7.7608e+00, 2.0660e-01,
 2DIAGNOSTIC,    21, -8.306050896645e-01, 5.804913143947e-06, 7.9638e+00, 2.0299e-01,
 2DIAGNOSTIC,    22, -8.306649327278e-01, 7.125260253815e-06, 8.1619e+00, 1.9812e-01,
 2DIAGNOSTIC,    23, -8.307245969772e-01, 8.689037713339e-06, 8.3666e+00, 2.0469e-01,
 2DIAGNOSTIC,    24, -8.307953476906e-01, 1.035478726408e-05, 8.5716e+00, 2.0496e-01,
 2DIAGNOSTIC,    25, -8.309625387192e-01, 1.311958385486e-05, 8.7831e+00, 2.1151e-01,
 2DIAGNOSTIC,    26, -8.311526179314e-01, 1.723921741359e-05, 9.0614e+00, 2.7832e-01,
 2DIAGNOSTIC,    27, -8.311910033226e-01, 2.024202331086e-05, 9.2638e+00, 2.0241e-01,
 2DIAGNOSTIC,    28, -8.312106728554e-01, 2.215646418335e-05, 9.5672e+00, 3.0340e-01,
 2DIAGNOSTIC,    29, -8.312203288078e-01, 2.208975820395e-05, 9.8401e+00, 2.7291e-01,
 2DIAGNOSTIC,    30, -8.312220573425e-01, 1.999683809117e-05, 1.0082e+01, 2.4198e-01,
 2DIAGNOSTIC,    31, -8.312352299690e-01, 1.676623651292e-05, 1.0324e+01, 2.4225e-01,
 2DIAGNOSTIC,    32, -8.312280774117e-01, 1.281250479224e-05, 1.0553e+01, 2.2835e-01,
 2DIAGNOSTIC,    33, -8.312379717827e-01, 8.729974979360e-06, 1.0790e+01, 2.3690e-01,
 2DIAGNOSTIC,    34, -8.312438726425e-01, 4.899353825749e-06, 1.1033e+01, 2.4363e-01,
 2DIAGNOSTIC,    35, -8.312260508537e-01, 2.323509079361e-06, 1.1260e+01, 2.2653e-01,
 2DIAGNOSTIC,    36, -8.312295079231e-01, 1.594739956090e-06, 1.1485e+01, 2.2493e-01,
 2DIAGNOSTIC,    37, -8.312106132507e-01, 1.012508391796e-06, 1.1743e+01, 2.5845e-01,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -7.161630392075e-01, inf, 1.2638e+01, 8.9442e-01,
 2DIAGNOSTIC,     2, -7.189758419991e-01, inf, 1.2880e+01, 2.4255e-01,
 2DIAGNOSTIC,     3, -7.206572890282e-01, inf, 1.3134e+01, 2.5408e-01,
 2DIAGNOSTIC,     4, -7.222486734390e-01, inf, 1.3509e+01, 3.7460e-01,
 2DIAGNOSTIC,     5, -7.225890159607e-01, inf, 1.3737e+01, 2.2831e-01,
 2DIAGNOSTIC,     6, -7.236638665199e-01, inf, 1.3970e+01, 2.3274e-01,
 2DIAGNOSTIC,     7, -7.245038747787e-01, inf, 1.4196e+01, 2.2632e-01,
 2DIAGNOSTIC,     8, -7.252046465874e-01, inf, 1.4411e+01, 2.1523e-01,
 2DIAGNOSTIC,     9, -7.259755730629e-01, inf, 1.4655e+01, 2.4405e-01,
 2DIAGNOSTIC,    10, -7.267730832100e-01, 8.348897099495e-04, 1.5121e+01, 4.6539e-01,
 2DIAGNOSTIC,    11, -7.267867326736e-01, 6.150202243589e-04, 1.5345e+01, 2.2452e-01,
 2DIAGNOSTIC,    12, -7.268183827400e-01, 4.695007519331e-04, 1.5589e+01, 2.4344e-01,
 2DIAGNOSTIC,    13, -7.268443703651e-01, 3.550207475200e-04, 1.5813e+01, 2.2393e-01,
 2DIAGNOSTIC,    14, -7.268578410149e-01, 2.699051110540e-04, 1.6028e+01, 2.1496e-01,
 2DIAGNOSTIC,    15, -7.269232273102e-01, 1.817122392822e-04, 1.6261e+01, 2.3306e-01,
 2DIAGNOSTIC,    16, -7.270224690437e-01, 1.167266018456e-04, 1.6470e+01, 2.0907e-01,
 2DIAGNOSTIC,    17, -7.271403074265e-01, 7.095153705450e-05, 1.6682e+01, 2.1255e-01,
 2DIAGNOSTIC,    18, -7.272970676422e-01, 4.228225225233e-05, 1.6898e+01, 2.1545e-01,
 2DIAGNOSTIC,    19, -7.274355292320e-01, 3.115826257272e-05, 1.7117e+01, 2.1871e-01,
 2DIAGNOSTIC,    20, -7.276029586792e-01, 3.730354364961e-05, 1.7339e+01, 2.2199e-01,
 2DIAGNOSTIC,    21, -7.278270125389e-01, 4.391042602947e-05, 1.7555e+01, 2.1658e-01,
 2DIAGNOSTIC,    22, -7.280545830727e-01, 5.049244646216e-05, 1.7806e+01, 2.5102e-01,
 2DIAGNOSTIC,    23, -7.281046509743e-01, 5.316245733411e-05, 1.8092e+01, 2.8591e-01,
 2DIAGNOSTIC,    24, -7.281637787819e-01, 5.198481449042e-05, 1.8304e+01, 2.1238e-01,
 2DIAGNOSTIC,    25, -7.281908988953e-01, 4.758846989716e-05, 1.8504e+01, 1.9955e-01,
 2DIAGNOSTIC,    26, -7.282438874245e-01, 4.141313547734e-05, 1.8802e+01, 2.9761e-01,
 2DIAGNOSTIC,    27, -7.282606959343e-01, 3.378988913028e-05, 1.9014e+01, 2.1223e-01,
 2DIAGNOSTIC,    28, -7.282687425613e-01, 2.594787110866e-05, 1.9257e+01, 2.4355e-01,
 2DIAGNOSTIC,    29, -7.282783389091e-01, 1.832040106819e-05, 1.9457e+01, 1.9990e-01,
 2DIAGNOSTIC,    30, -7.282879352570e-01, 1.183750646305e-05, 1.9697e+01, 2.4001e-01,
 2DIAGNOSTIC,    31, -7.282989025116e-01, 7.645769073861e-06, 2.0026e+01, 3.2890e-01,
 2DIAGNOSTIC,    32, -7.283018827438e-01, 5.899681582378e-06, 2.0270e+01, 2.4385e-01,
 2DIAGNOSTIC,    33, -7.283016443253e-01, 4.379357051221e-06, 2.0502e+01, 2.3213e-01,
 2DIAGNOSTIC,    34, -7.283019423485e-01, 3.310230567877e-06, 2.0786e+01, 2.8385e-01,
 2DIAGNOSTIC,    35, -7.283014059067e-01, 2.358691290283e-06, 2.1019e+01, 2.3280e-01,
 2DIAGNOSTIC,    36, -7.283014059067e-01, 1.893610146908e-06, 2.1259e+01, 2.4070e-01,
 2DIAGNOSTIC,    37, -7.283008098602e-01, 1.528742586743e-06, 2.1501e+01, 2.4176e-01,
 2DIAGNOSTIC,    38, -7.283016443253e-01, 1.211260041600e-06, 2.1738e+01, 2.3644e-01,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -6.196758747101e-01, inf, 2.4217e+01, 2.4798e+00,
  Elapsed time (stage 0): 2.5230e+01

Stage 1
  iterations = 0x0x0x0
  convergence threshold = 1.0000e-07
  convergence window size = 8
  number of levels = 4
  using the Mattes MI metric (number of bins = 32, weight = 1.0000e+00)
  preprocessing:  histogram matching the images
  Shrink factors (level 1 out of 4): [8, 8, 8]
  Shrink factors (level 2 out of 4): [4, 4, 4]
  Shrink factors (level 3 out of 4): [2, 2, 2]
  Shrink factors (level 4 out of 4): [1, 1, 1]
  smoothing sigmas per level: [3, 2, 1, 0]
  Using default NONE metricSamplingStrategy

*** Running SyN registration (varianceForUpdateField = 3.0000e+00, varianceForTotalField = 0.0000e+00) ***

  Elapsed time (stage 1): 4.4198e+00

Total elapsed time: 2.9683e+01
0.0
All_Command_lines_OK
Using single precision for computations.
=============================================================================
The composite transform comprises the following transforms (in order):
  1. Center of mass alignment using fixed image: 0x11e0e310 and moving image: 0x108eee80 (type = Euler3DTransform)
=============================================================================
  Reading mask(s).
    Registration stage 0
      No fixed mask
      No moving mask
    Registration stage 1
      No fixed mask
      No moving mask
  number of levels = 4
  number of levels = 4
  fixed image: 0x11e0e310
  moving image: 0x108eee80
  fixed image: 0x11e0e310
  moving image: 0x108eee80
Dimension = 3
Number of stages = 2
Use Histogram Matching true
Winsorize image intensities false
Lower quantile = 0.0000e+00
Upper quantile = 1.0000e+00
Stage 1 State
   Image metric = Mattes
     Fixed image = Image (0x1283e410)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 21993652
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 21993626
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [9.0212e+01, 8.9871e+01, -1.3853e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x11819c80)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 21993624
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff7756bf010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Moving image = Image (0x127cfe00)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 21993653
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 21993650
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [9.0212e+01, 8.9871e+01, -1.3853e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x11db1a10)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 21993648
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff772d7e010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Weighting = 1.0000e+00
     Sampling strategy = regular
     Number of bins = 32
     Radius = 4
     Sampling percentage  = 2.0000e-01
   Transform = Affine
     Gradient step = 2.5000e-01
     Update field sigma (voxel space) = 0.0000e+00
     Total field sigma (voxel space) = 0.0000e+00
     Update field time sigma = 0.0000e+00
     Total field time sigma  = 0.0000e+00
     Number of time indices = 0
     Number of time point samples = 0
Stage 2 State
   Image metric = Mattes
     Fixed image = Image (0x127f1fb0)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 21993702
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 21993676
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [9.0212e+01, 8.9871e+01, -1.3853e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x12786170)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 21993674
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff7616bf010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Moving image = Image (0x127e20a0)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 21993703
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 21993700
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [9.0212e+01, 8.9871e+01, -1.3853e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x10dd5560)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 21993698
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff756d7e010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Weighting = 1.0000e+00
     Sampling strategy = none
     Number of bins = 32
     Radius = 4
     Sampling percentage  = 1.0000e+00
   Transform = SyN
     Gradient step = 2.0000e-01
     Update field sigma (voxel space) = 3.0000e+00
     Total field sigma (voxel space) = 0.0000e+00
     Update field time sigma = 0.0000e+00
     Total field time sigma  = 0.0000e+00
     Number of time indices = 0
     Number of time point samples = 0
Registration using 2 total stages.

Stage 0
  iterations = 2100x1200x1200x0
  convergence threshold = 1.0000e-06
  convergence window size = 10
  number of levels = 4
  using the Mattes MI metric (number of bins = 32, weight = 1.0000e+00)
  preprocessing:  histogram matching the images
  Shrink factors (level 1 out of 4): [4, 4, 4]
  Shrink factors (level 2 out of 4): [2, 2, 2]
  Shrink factors (level 3 out of 4): [2, 2, 2]
  Shrink factors (level 4 out of 4): [1, 1, 1]
  smoothing sigmas per level: [3, 2, 1, 0]
  regular sampling (percentage = 2.0000e-01)

*** Running AffineTransform registration ***

DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -9.955253601074e-01, inf, 4.3552e-01, 4.3552e-01,
 2DIAGNOSTIC,     2, -1.013192057610e+00, inf, 4.8066e-01, 4.5146e-02,
 2DIAGNOSTIC,     3, -1.036209821701e+00, inf, 5.3286e-01, 5.2198e-02,
 2DIAGNOSTIC,     4, -1.056669116020e+00, inf, 5.7970e-01, 4.6838e-02,
 2DIAGNOSTIC,     5, -1.065818309784e+00, inf, 6.2558e-01, 4.5880e-02,
 2DIAGNOSTIC,     6, -1.071194410324e+00, inf, 6.8304e-01, 5.7462e-02,
 2DIAGNOSTIC,     7, -1.075660824776e+00, inf, 7.5392e-01, 7.0878e-02,
 2DIAGNOSTIC,     8, -1.076143264771e+00, inf, 7.9744e-01, 4.3521e-02,
 2DIAGNOSTIC,     9, -1.077571511269e+00, inf, 8.4187e-01, 4.4435e-02,
 2DIAGNOSTIC,    10, -1.078835844994e+00, 4.782194271684e-03, 8.8662e-01, 4.4750e-02,
 2DIAGNOSTIC,    11, -1.079748868942e+00, 3.034780966118e-03, 9.3048e-01, 4.3860e-02,
 2DIAGNOSTIC,    12, -1.080770730972e+00, 1.723059802316e-03, 9.8072e-01, 5.0231e-02,
 2DIAGNOSTIC,    13, -1.081522583961e+00, 9.432032820769e-04, 1.0599e+00, 7.9174e-02,
 2DIAGNOSTIC,    14, -1.081543684006e+00, 5.800310173072e-04, 1.1042e+00, 4.4295e-02,
 2DIAGNOSTIC,    15, -1.081903100014e+00, 3.810925700236e-04, 1.1481e+00, 4.3873e-02,
 2DIAGNOSTIC,    16, -1.082410454750e+00, 2.688536187634e-04, 1.1958e+00, 4.7745e-02,
 2DIAGNOSTIC,    17, -1.082956671715e+00, 2.239667956019e-04, 1.2410e+00, 4.5150e-02,
 2DIAGNOSTIC,    18, -1.083335518837e+00, 1.759322476573e-04, 1.2873e+00, 4.6392e-02,
 2DIAGNOSTIC,    19, -1.083612084389e+00, 1.406617957400e-04, 1.3321e+00, 4.4766e-02,
 2DIAGNOSTIC,    20, -1.083785295486e+00, 1.151298638433e-04, 1.4065e+00, 7.4428e-02,
 2DIAGNOSTIC,    21, -1.083851099014e+00, 9.353956556879e-05, 1.4511e+00, 4.4513e-02,
 2DIAGNOSTIC,    22, -1.083870172501e+00, 7.764138717903e-05, 1.4958e+00, 4.4711e-02,
 2DIAGNOSTIC,    23, -1.083939552307e+00, 6.556433800142e-05, 1.5440e+00, 4.8221e-02,
 2DIAGNOSTIC,    24, -1.084022641182e+00, 4.961624654243e-05, 1.5889e+00, 4.4910e-02,
 2DIAGNOSTIC,    25, -1.084164261818e+00, 3.566684245015e-05, 1.6570e+00, 6.8076e-02,
 2DIAGNOSTIC,    26, -1.084211230278e+00, 2.511745333322e-05, 1.7137e+00, 5.6684e-02,
 2DIAGNOSTIC,    27, -1.084217667580e+00, 1.849649379437e-05, 1.7591e+00, 4.5464e-02,
 2DIAGNOSTIC,    28, -1.084241747856e+00, 1.449940373277e-05, 1.8046e+00, 4.5439e-02,
 2DIAGNOSTIC,    29, -1.084348917007e+00, 1.297027847613e-05, 1.8607e+00, 5.6135e-02,
 2DIAGNOSTIC,    30, -1.084377169609e+00, 1.214693384100e-05, 1.9071e+00, 4.6382e-02,
 2DIAGNOSTIC,    31, -1.084374666214e+00, 1.087945292966e-05, 1.9529e+00, 4.5802e-02,
 2DIAGNOSTIC,    32, -1.084465622902e+00, 9.694705113361e-06, 2.0207e+00, 6.7788e-02,
 2DIAGNOSTIC,    33, -1.084487915039e+00, 8.469588465232e-06, 2.0723e+00, 5.1653e-02,
 2DIAGNOSTIC,    34, -1.084489822388e+00, 7.227894457174e-06, 2.1297e+00, 5.7405e-02,
 2DIAGNOSTIC,    35, -1.084490060806e+00, 6.531802227983e-06, 2.1856e+00, 5.5843e-02,
 2DIAGNOSTIC,    36, -1.084490299225e+00, 5.700794190489e-06, 2.2488e+00, 6.3248e-02,
 2DIAGNOSTIC,    37, -1.084490418434e+00, 4.500537215790e-06, 2.3047e+00, 5.5841e-02,
 2DIAGNOSTIC,    38, -1.084490180016e+00, 3.159377001793e-06, 2.3792e+00, 7.4539e-02,
 2DIAGNOSTIC,    39, -1.084490418434e+00, 2.397861862846e-06, 2.4298e+00, 5.0570e-02,
 2DIAGNOSTIC,    40, -1.084490418434e+00, 1.720929731164e-06, 2.4811e+00, 5.1327e-02,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -9.771502017975e-01, inf, 3.2079e+00, 7.2682e-01,
 2DIAGNOSTIC,     2, -9.779115319252e-01, inf, 3.4051e+00, 1.9715e-01,
 2DIAGNOSTIC,     3, -9.784396886826e-01, inf, 3.5906e+00, 1.8557e-01,
 2DIAGNOSTIC,     4, -9.791404604912e-01, inf, 3.8091e+00, 2.1842e-01,
 2DIAGNOSTIC,     5, -9.795799851418e-01, inf, 4.1282e+00, 3.1914e-01,
 2DIAGNOSTIC,     6, -9.795902371407e-01, inf, 4.3285e+00, 2.0032e-01,
 2DIAGNOSTIC,     7, -9.796574711800e-01, inf, 4.5181e+00, 1.8955e-01,
 2DIAGNOSTIC,     8, -9.797000885010e-01, inf, 4.7412e+00, 2.2310e-01,
 2DIAGNOSTIC,     9, -9.797345399857e-01, inf, 4.9291e+00, 1.8794e-01,
 2DIAGNOSTIC,    10, -9.797585606575e-01, 1.578744995641e-04, 5.1381e+00, 2.0898e-01,
 2DIAGNOSTIC,    11, -9.797896742821e-01, 9.563587082084e-05, 5.3600e+00, 2.2188e-01,
 2DIAGNOSTIC,    12, -9.797967076302e-01, 5.402462920756e-05, 5.5887e+00, 2.2879e-01,
 2DIAGNOSTIC,    13, -9.797946810722e-01, 2.558830783528e-05, 5.7871e+00, 1.9839e-01,
 2DIAGNOSTIC,    14, -9.798038601875e-01, 1.359254474664e-05, 6.0324e+00, 2.4530e-01,
 2DIAGNOSTIC,    15, -9.798142313957e-01, 1.087560576707e-05, 6.2747e+00, 2.4229e-01,
 2DIAGNOSTIC,    16, -9.798107147217e-01, 7.786824426148e-06, 6.4845e+00, 2.0976e-01,
 2DIAGNOSTIC,    17, -9.798099398613e-01, 5.657771453116e-06, 6.6970e+00, 2.1248e-01,
 2DIAGNOSTIC,    18, -9.798078536987e-01, 4.067977442901e-06, 6.9234e+00, 2.2643e-01,
 2DIAGNOSTIC,    19, -9.798066020012e-01, 2.933531050076e-06, 7.1928e+00, 2.6941e-01,
 2DIAGNOSTIC,    20, -9.798054099083e-01, 2.111762796631e-06, 7.4169e+00, 2.2405e-01,
 2DIAGNOSTIC,    21, -9.798051714897e-01, 1.745467216097e-06, 7.6288e+00, 2.1192e-01,
 2DIAGNOSTIC,    22, -9.798030257225e-01, 1.459998429709e-06, 7.8557e+00, 2.2690e-01,
 2DIAGNOSTIC,    23, -9.798020124435e-01, 1.158305281024e-06, 8.1585e+00, 3.0287e-01,
 2DIAGNOSTIC,    24, -9.798023700714e-01, 1.014302370095e-06, 8.4128e+00, 2.5429e-01,
 2DIAGNOSTIC,    25, -9.798023700714e-01, 1.031745910041e-06, 8.6967e+00, 2.8385e-01,
 2DIAGNOSTIC,    26, -9.798021316528e-01, 1.028399651659e-06, 8.9487e+00, 2.5200e-01,
 2DIAGNOSTIC,    27, -9.797991514206e-01, 1.004202772492e-06, 9.2040e+00, 2.5535e-01,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -8.657045364380e-01, inf, 1.0027e+01, 8.2318e-01,
 2DIAGNOSTIC,     2, -8.683163523674e-01, inf, 1.0220e+01, 1.9303e-01,
 2DIAGNOSTIC,     3, -8.698000311852e-01, inf, 1.0462e+01, 2.4145e-01,
 2DIAGNOSTIC,     4, -8.704812526703e-01, inf, 1.0678e+01, 2.1598e-01,
 2DIAGNOSTIC,     5, -8.724499940872e-01, inf, 1.0894e+01, 2.1627e-01,
 2DIAGNOSTIC,     6, -8.735153079033e-01, inf, 1.1087e+01, 1.9257e-01,
 2DIAGNOSTIC,     7, -8.737663030624e-01, inf, 1.1444e+01, 3.5721e-01,
 2DIAGNOSTIC,     8, -8.737855553627e-01, inf, 1.1647e+01, 2.0280e-01,
 2DIAGNOSTIC,     9, -8.738356232643e-01, inf, 1.1848e+01, 2.0129e-01,
 2DIAGNOSTIC,    10, -8.739023804665e-01, 5.747402901761e-04, 1.2064e+01, 2.1627e-01,
 2DIAGNOSTIC,    11, -8.739598989487e-01, 3.658854402602e-04, 1.2272e+01, 2.0747e-01,
 2DIAGNOSTIC,    12, -8.740261197090e-01, 2.318324550288e-04, 1.2473e+01, 2.0165e-01,
 2DIAGNOSTIC,    13, -8.740978240967e-01, 1.372503465973e-04, 1.2690e+01, 2.1638e-01,
 2DIAGNOSTIC,    14, -8.741990923882e-01, 6.122309423517e-05, 1.2948e+01, 2.5801e-01,
 2DIAGNOSTIC,    15, -8.742185831070e-01, 3.250961162848e-05, 1.3248e+01, 3.0035e-01,
 2DIAGNOSTIC,    16, -8.742426037788e-01, 2.666564978426e-05, 1.3491e+01, 2.4272e-01,
 2DIAGNOSTIC,    17, -8.742656111717e-01, 2.450282590871e-05, 1.3736e+01, 2.4537e-01,
 2DIAGNOSTIC,    18, -8.742859363556e-01, 2.117790427292e-05, 1.3993e+01, 2.5728e-01,
 2DIAGNOSTIC,    19, -8.742924928665e-01, 1.733968019835e-05, 1.4271e+01, 2.7721e-01,
 2DIAGNOSTIC,    20, -8.742883205414e-01, 1.344868451270e-05, 1.4566e+01, 2.9567e-01,
 2DIAGNOSTIC,    21, -8.742879629135e-01, 9.719704394229e-06, 1.4804e+01, 2.3750e-01,
 2DIAGNOSTIC,    22, -8.742847442627e-01, 6.481835043814e-06, 1.5027e+01, 2.2356e-01,
 2DIAGNOSTIC,    23, -8.742843270302e-01, 4.025566340715e-06, 1.5311e+01, 2.8399e-01,
 2DIAGNOSTIC,    24, -8.742851614952e-01, 2.910257535405e-06, 1.5565e+01, 2.5422e-01,
 2DIAGNOSTIC,    25, -8.742837905884e-01, 1.970076027646e-06, 1.5815e+01, 2.4980e-01,
 2DIAGNOSTIC,    26, -8.742846250534e-01, 1.345096620753e-06, 1.6039e+01, 2.2401e-01,
 2DIAGNOSTIC,    27, -8.742845058441e-01, 1.024528728522e-06, 1.6259e+01, 2.2019e-01,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -7.693172693253e-01, inf, 1.8845e+01, 2.5859e+00,
  Elapsed time (stage 0): 1.9804e+01

Stage 1
  iterations = 0x0x0x0
  convergence threshold = 1.0000e-07
  convergence window size = 8
  number of levels = 4
  using the Mattes MI metric (number of bins = 32, weight = 1.0000e+00)
  preprocessing:  histogram matching the images
  Shrink factors (level 1 out of 4): [8, 8, 8]
  Shrink factors (level 2 out of 4): [4, 4, 4]
  Shrink factors (level 3 out of 4): [2, 2, 2]
  Shrink factors (level 4 out of 4): [1, 1, 1]
  smoothing sigmas per level: [3, 2, 1, 0]
  Using default NONE metricSamplingStrategy

*** Running SyN registration (varianceForUpdateField = 3.0000e+00, varianceForTotalField = 0.0000e+00) ***

  Elapsed time (stage 1): 4.4891e+00

Total elapsed time: 2.4320e+01
All_Command_lines_OK
Using single precision for computations.
=============================================================================
The composite transform comprises the following transforms (in order):
  1. Center of mass alignment using fixed image: 0x118150e0 and moving image: 0x118d04e0 (type = Euler3DTransform)
=============================================================================
  Reading mask(s).
    Registration stage 0
      No fixed mask
      No moving mask
    Registration stage 1
      No fixed mask
      No moving mask
  number of levels = 4
  number of levels = 4
  fixed image: 0x118150e0
  moving image: 0x118d04e0
  fixed image: 0x118150e0
  moving image: 0x118d04e0
Dimension = 3
Number of stages = 2
Use Histogram Matching true
Winsorize image intensities false
Lower quantile = 0.0000e+00
Upper quantile = 1.0000e+00
Stage 1 State
   Image metric = Mattes
     Fixed image = Image (0x127d0550)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 27489416
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 27489390
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [9.0212e+01, 8.9871e+01, -1.3853e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x12757890)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 27489388
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff77043d010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Moving image = Image (0x1283bf00)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 27489417
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 27489414
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [8.6557e+01, 8.7864e+01, -1.4492e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x10dd5560)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 27489412
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff7696bf010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Weighting = 1.0000e+00
     Sampling strategy = regular
     Number of bins = 32
     Radius = 4
     Sampling percentage  = 2.0000e-01
   Transform = Affine
     Gradient step = 2.5000e-01
     Update field sigma (voxel space) = 0.0000e+00
     Total field sigma (voxel space) = 0.0000e+00
     Update field time sigma = 0.0000e+00
     Total field time sigma  = 0.0000e+00
     Number of time indices = 0
     Number of time point samples = 0
Stage 2 State
   Image metric = Mattes
     Fixed image = Image (0x127b8750)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 27489466
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 27489440
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [9.0212e+01, 8.9871e+01, -1.3853e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x12786170)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 27489438
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff7616bf010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Moving image = Image (0x127d42b0)
  RTTI typeinfo:   itk::Image<float, 3u>
  Reference Count: 2
  Modified Time: 27489467
  Debug: Off
  Object Name:
  Observers:
    none
  Source: (none)
  Source output name: (none)
  Release Data: Off
  Data Released: False
  Global Release Data: Off
  PipelineMTime: 0
  UpdateMTime: 27489464
  RealTimeStamp: 0.0000e+00 seconds
  LargestPossibleRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  BufferedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  RequestedRegion:
    Dimension: 3
    Index: [0, 0, 0]
    Size: [176, 240, 256]
  Spacing: [1.0000e+00, 1.0000e+00, 1.0000e+00]
  Origin: [8.6557e+01, 8.7864e+01, -1.4492e+02]
  Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  IndexToPointMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PointToIndexMatrix:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  Inverse Direction:
-1.0000e+00 0.0000e+00 0.0000e+00
0.0000e+00 -1.0000e+00 0.0000e+00
0.0000e+00 0.0000e+00 1.0000e+00

  PixelContainer:
    ImportImageContainer (0x11d4b6a0)
      RTTI typeinfo:   itk::ImportImageContainer<unsigned long, float>
      Reference Count: 1
      Modified Time: 27489462
      Debug: Off
      Object Name:
      Observers:
        none
      Pointer: 0x7ff756d7e010
      Container manages memory: true
      Size: 10813440
      Capacity: 10813440

     Weighting = 1.0000e+00
     Sampling strategy = none
     Number of bins = 32
     Radius = 4
     Sampling percentage  = 1.0000e+00
   Transform = SyN
     Gradient step = 2.0000e-01
     Update field sigma (voxel space) = 3.0000e+00
     Total field sigma (voxel space) = 0.0000e+00
     Update field time sigma = 0.0000e+00
     Total field time sigma  = 0.0000e+00
     Number of time indices = 0
     Number of time point samples = 0
Registration using 2 total stages.

Stage 0
  iterations = 2100x1200x1200x0
  convergence threshold = 1.0000e-06
  convergence window size = 10
  number of levels = 4
  using the Mattes MI metric (number of bins = 32, weight = 1.0000e+00)
  preprocessing:  histogram matching the images
  Shrink factors (level 1 out of 4): [4, 4, 4]
  Shrink factors (level 2 out of 4): [2, 2, 2]
  Shrink factors (level 3 out of 4): [2, 2, 2]
  Shrink factors (level 4 out of 4): [1, 1, 1]
  smoothing sigmas per level: [3, 2, 1, 0]
  regular sampling (percentage = 2.0000e-01)

*** Running AffineTransform registration ***

DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -6.121281981468e-01, inf, 4.3258e-01, 4.3258e-01,
 2DIAGNOSTIC,     2, -6.169722676277e-01, inf, 4.7702e-01, 4.4440e-02,
 2DIAGNOSTIC,     3, -6.250947713852e-01, inf, 5.2372e-01, 4.6697e-02,
 2DIAGNOSTIC,     4, -6.400976777077e-01, inf, 5.7137e-01, 4.7657e-02,
 2DIAGNOSTIC,     5, -6.681856513023e-01, inf, 6.1858e-01, 4.7209e-02,
 2DIAGNOSTIC,     6, -7.184521555901e-01, inf, 6.7389e-01, 5.5310e-02,
 2DIAGNOSTIC,     7, -7.520496845245e-01, inf, 7.3710e-01, 6.3208e-02,
 2DIAGNOSTIC,     8, -7.670615911484e-01, inf, 7.8733e-01, 5.0231e-02,
 2DIAGNOSTIC,     9, -7.962933182716e-01, inf, 8.4145e-01, 5.4117e-02,
 2DIAGNOSTIC,    10, -8.330998420715e-01, 2.175007387996e-02, 9.1687e-01, 7.5416e-02,
 2DIAGNOSTIC,    11, -8.384220004082e-01, 2.039584703743e-02, 9.6294e-01, 4.6076e-02,
 2DIAGNOSTIC,    12, -8.653084039688e-01, 1.849031820893e-02, 1.0237e+00, 6.0758e-02,
 2DIAGNOSTIC,    13, -8.994338512421e-01, 1.647933386266e-02, 1.0749e+00, 5.1212e-02,
 2DIAGNOSTIC,    14, -9.043653011322e-01, 1.384483929724e-02, 1.1256e+00, 5.0686e-02,
 2DIAGNOSTIC,    15, -9.089257717133e-01, 1.116570644081e-02, 1.1815e+00, 5.5911e-02,
 2DIAGNOSTIC,    16, -9.165577292442e-01, 9.191933088005e-03, 1.2405e+00, 5.8983e-02,
 2DIAGNOSTIC,    17, -9.256351590157e-01, 7.558507379144e-03, 1.2981e+00, 5.7621e-02,
 2DIAGNOSTIC,    18, -9.301785826683e-01, 5.814075004309e-03, 1.3552e+00, 5.7061e-02,
 2DIAGNOSTIC,    19, -9.317278862000e-01, 4.314624238759e-03, 1.4035e+00, 4.8313e-02,
 2DIAGNOSTIC,    20, -9.332288503647e-01, 3.281685989350e-03, 1.4775e+00, 7.4004e-02,
 2DIAGNOSTIC,    21, -9.336701631546e-01, 2.148188883439e-03, 1.5252e+00, 4.7671e-02,
 2DIAGNOSTIC,    22, -9.347962141037e-01, 1.360965310596e-03, 1.5729e+00, 4.7717e-02,
 2DIAGNOSTIC,    23, -9.355949163437e-01, 1.049577142112e-03, 1.6265e+00, 5.3595e-02,
 2DIAGNOSTIC,    24, -9.357761740685e-01, 7.440431509167e-04, 1.6759e+00, 4.9412e-02,
 2DIAGNOSTIC,    25, -9.358991384506e-01, 4.601950640790e-04, 1.7239e+00, 4.8064e-02,
 2DIAGNOSTIC,    26, -9.360072612762e-01, 2.568596391939e-04, 1.8109e+00, 8.6950e-02,
 2DIAGNOSTIC,    27, -9.359318017960e-01, 1.580639509484e-04, 1.8656e+00, 5.4666e-02,
 2DIAGNOSTIC,    28, -9.358581304550e-01, 1.059098358382e-04, 1.9178e+00, 5.2282e-02,
 2DIAGNOSTIC,    29, -9.358511567116e-01, 6.551853584824e-05, 1.9711e+00, 5.3208e-02,
 2DIAGNOSTIC,    30, -9.358528256416e-01, 3.892787572113e-05, 2.0271e+00, 5.6004e-02,
 2DIAGNOSTIC,    31, -9.358536601067e-01, 1.517834516562e-05, 2.0792e+00, 5.2172e-02,
 2DIAGNOSTIC,    32, -9.358548521996e-01, 3.276181132605e-06, 2.1307e+00, 5.1510e-02,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -8.364869952202e-01, inf, 2.8849e+00, 7.5418e-01,
 2DIAGNOSTIC,     2, -8.378932476044e-01, inf, 3.0779e+00, 1.9293e-01,
 2DIAGNOSTIC,     3, -8.383556008339e-01, inf, 3.2868e+00, 2.0893e-01,
 2DIAGNOSTIC,     4, -8.392048478127e-01, inf, 3.5637e+00, 2.7692e-01,
 2DIAGNOSTIC,     5, -8.393927812576e-01, inf, 3.7578e+00, 1.9406e-01,
 2DIAGNOSTIC,     6, -8.394866585732e-01, inf, 3.9838e+00, 2.2604e-01,
 2DIAGNOSTIC,     7, -8.395627140999e-01, inf, 4.1696e+00, 1.8578e-01,
 2DIAGNOSTIC,     8, -8.398941755295e-01, inf, 4.4412e+00, 2.7164e-01,
 2DIAGNOSTIC,     9, -8.400276303291e-01, inf, 4.6606e+00, 2.1939e-01,
 2DIAGNOSTIC,    10, -8.399877548218e-01, 2.277062012581e-04, 4.9134e+00, 2.5282e-01,
 2DIAGNOSTIC,    11, -8.400101065636e-01, 1.373572740704e-04, 5.1632e+00, 2.4973e-01,
 2DIAGNOSTIC,    12, -8.400220870972e-01, 9.000156569527e-05, 5.3800e+00, 2.1681e-01,
 2DIAGNOSTIC,    13, -8.400247693062e-01, 5.344525925466e-05, 5.5753e+00, 1.9527e-01,
 2DIAGNOSTIC,    14, -8.400327563286e-01, 3.807482062257e-05, 5.7614e+00, 1.8615e-01,
 2DIAGNOSTIC,    15, -8.400468230247e-01, 2.613091783132e-05, 5.9845e+00, 2.2311e-01,
 2DIAGNOSTIC,    16, -8.400566577911e-01, 1.574749512656e-05, 6.2003e+00, 2.1576e-01,
 2DIAGNOSTIC,    17, -8.400642871857e-01, 6.810915692768e-06, 6.4373e+00, 2.3705e-01,
 2DIAGNOSTIC,    18, -8.400794267654e-01, 4.856868144998e-06, 6.7245e+00, 2.8718e-01,
 2DIAGNOSTIC,    19, -8.400837779045e-01, 5.299811164150e-06, 6.9606e+00, 2.3607e-01,
 2DIAGNOSTIC,    20, -8.400871157646e-01, 4.733448349725e-06, 7.2192e+00, 2.5859e-01,
 2DIAGNOSTIC,    21, -8.400886058807e-01, 4.309080395615e-06, 7.4787e+00, 2.5951e-01,
 2DIAGNOSTIC,    22, -8.400894403458e-01, 3.861143795802e-06, 7.7091e+00, 2.3046e-01,
 2DIAGNOSTIC,    23, -8.400761485100e-01, 3.067932993872e-06, 7.9286e+00, 2.1951e-01,
 2DIAGNOSTIC,    24, -8.400772809982e-01, 2.313181084901e-06, 8.1979e+00, 2.6926e-01,
 2DIAGNOSTIC,    25, -8.400779366493e-01, 1.722776460156e-06, 8.4236e+00, 2.2574e-01,
 2DIAGNOSTIC,    26, -8.400771617889e-01, 1.250492914551e-06, 8.6358e+00, 2.1217e-01,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -7.300127148628e-01, inf, 9.4144e+00, 7.7857e-01,
 2DIAGNOSTIC,     2, -7.332433462143e-01, inf, 9.6147e+00, 2.0030e-01,
 2DIAGNOSTIC,     3, -7.345694899559e-01, inf, 9.8949e+00, 2.8027e-01,
 2DIAGNOSTIC,     4, -7.352175116539e-01, inf, 1.0112e+01, 2.1685e-01,
 2DIAGNOSTIC,     5, -7.360184788704e-01, inf, 1.0299e+01, 1.8745e-01,
 2DIAGNOSTIC,     6, -7.375341057777e-01, inf, 1.0537e+01, 2.3751e-01,
 2DIAGNOSTIC,     7, -7.381378412247e-01, inf, 1.0786e+01, 2.4921e-01,
 2DIAGNOSTIC,     8, -7.385416626930e-01, inf, 1.0990e+01, 2.0395e-01,
 2DIAGNOSTIC,     9, -7.389795780182e-01, inf, 1.1210e+01, 2.2021e-01,
 2DIAGNOSTIC,    10, -7.390516996384e-01, 7.156219216995e-04, 1.1409e+01, 1.9870e-01,
 2DIAGNOSTIC,    11, -7.391863465309e-01, 4.862962814514e-04, 1.1614e+01, 2.0477e-01,
 2DIAGNOSTIC,    12, -7.394972443581e-01, 3.648696001619e-04, 1.1883e+01, 2.6929e-01,
 2DIAGNOSTIC,    13, -7.398090362549e-01, 2.780509821605e-04, 1.2162e+01, 2.7870e-01,
 2DIAGNOSTIC,    14, -7.398780584335e-01, 1.982092071557e-04, 1.2390e+01, 2.2826e-01,
 2DIAGNOSTIC,    15, -7.399194836617e-01, 1.321435265709e-04, 1.2627e+01, 2.3733e-01,
 2DIAGNOSTIC,    16, -7.399333715439e-01, 9.918088471750e-05, 1.2859e+01, 2.3226e-01,
 2DIAGNOSTIC,    17, -7.399394512177e-01, 7.473934238078e-05, 1.3105e+01, 2.4545e-01,
 2DIAGNOSTIC,    18, -7.399427890778e-01, 5.467383016367e-05, 1.3364e+01, 2.5925e-01,
 2DIAGNOSTIC,    19, -7.399433851242e-01, 4.076219920535e-05, 1.3630e+01, 2.6579e-01,
 2DIAGNOSTIC,    20, -7.399435639381e-01, 2.608507929835e-05, 1.3863e+01, 2.3333e-01,
 2DIAGNOSTIC,    21, -7.399446964264e-01, 1.293752211495e-05, 1.4106e+01, 2.4275e-01,
 2DIAGNOSTIC,    22, -7.399441599846e-01, 5.220459570410e-06, 1.4366e+01, 2.6027e-01,
 2DIAGNOSTIC,    23, -7.399460077286e-01, 3.051363819395e-06, 1.4608e+01, 2.4149e-01,
 2DIAGNOSTIC,    24, -7.399461269379e-01, 2.000565018534e-06, 1.4860e+01, 2.5176e-01,
 2DIAGNOSTIC,    25, -7.399455904961e-01, 1.596297238393e-06, 1.5197e+01, 3.3799e-01,
 2DIAGNOSTIC,    26, -7.399466037750e-01, 1.412164124304e-06, 1.5469e+01, 2.7115e-01,
 2DIAGNOSTIC,    27, -7.399460673332e-01, 1.301447014157e-06, 1.5714e+01, 2.4521e-01,
 2DIAGNOSTIC,    28, -7.399460077286e-01, 1.232201839230e-06, 1.5967e+01, 2.5282e-01,
 2DIAGNOSTIC,    29, -7.399463057518e-01, 1.170792529592e-06, 1.6238e+01, 2.7106e-01,
 2DIAGNOSTIC,    30, -7.399464845657e-01, 1.110993821385e-06, 1.6506e+01, 2.6849e-01,
 2DIAGNOSTIC,    31, -7.399463057518e-01, 1.062579258360e-06, 1.6780e+01, 2.7341e-01,
 2DIAGNOSTIC,    32, -7.399462461472e-01, 1.006230036182e-06, 1.7061e+01, 2.8108e-01,
DIAGNOSTIC,Iteration,metricValue,convergenceValue,ITERATION_TIME_INDEX,SINCE_LAST
 2DIAGNOSTIC,     1, -6.373375654221e-01, inf, 1.9653e+01, 2.5927e+00,
  Elapsed time (stage 0): 2.0622e+01

Stage 1
  iterations = 0x0x0x0
  convergence threshold = 1.0000e-07
  convergence window size = 8
  number of levels = 4
  using the Mattes MI metric (number of bins = 32, weight = 1.0000e+00)
  preprocessing:  histogram matching the images
  Shrink factors (level 1 out of 4): [8, 8, 8]
  Shrink factors (level 2 out of 4): [4, 4, 4]
  Shrink factors (level 3 out of 4): [2, 2, 2]
  Shrink factors (level 4 out of 4): [1, 1, 1]
  smoothing sigmas per level: [3, 2, 1, 0]
  Using default NONE metricSamplingStrategy

*** Running SyN registration (varianceForUpdateField = 3.0000e+00, varianceForTotalField = 0.0000e+00) ***

  Elapsed time (stage 1): 4.6689e+00

Total elapsed time: 2.5317e+01
0.0

The smoothing sigmas and shrink factors in the code I pass to ants does not match the shrink factors and smoothing sigmas in the log.

stnava commented 4 years ago

stale issue.