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AlexandrovLab / SigProfilerExtractor

SigProfilerExtractor allows de novo extraction of mutational signatures from data generated in a matrix format. The tool identifies the number of operative mutational signatures, their activities in each sample, and the probability for each signature to cause a specific mutation type in a cancer sample. The tool makes use of SigProfilerMatrixGenerator and SigProfilerPlotting.
BSD 2-Clause "Simplified" License
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Sample contribution mutational signatures #155

Closed msubirana closed 2 years ago

msubirana commented 2 years ago

Is it possible to extract the contribution of each sample to the extracted signatures?

Something like:

image

marcos-diazg commented 2 years ago

Dear @msubirana,

Thanks for your question. The image you posted does not correspond to a SigProfilerExtractor output but rather to another mutational signature extraction tool, and it's actually representing the contribution of each extracted signature to each sample.

SigProfilerExtractor has an extensive documentation about the output files that you can check on our wiki page and video tutorials. The files you are looking for are the activity results and plots.

Please feel free to reopen the ticket if you have further questions.