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AlexandrovLab / SigProfilerExtractorR

An R wrapper for SigProfilerExtractor that allows de novo extraction of mutational signatures from data generated in a matrix format. The tool identifies the number of operative mutational signatures, their activities in each sample, and the probability for each signature to cause a specific mutation type in a cancer sample. The tool makes use of SigProfilerMatrixGenerator and SigProfilerPlotting.
BSD 2-Clause "Simplified" License
15 stars 2 forks source link

simultaneous analysis of genomes and exomes #4

Closed MariaCartolano closed 3 years ago

MariaCartolano commented 3 years ago

Hello,

I would like to analyze in the same batch WGS and WES data. Is it possible to do this using the SigProfilerExtractor? How is exome normalisation performed?

Thank you in advance for your help. Maria

mishugeb commented 3 years ago

Hi Maria, Sorry for the delayed response as I did not get any notification of this issue in the repository. If you use "exome=TRUE", that will analyze the WES data. If you use "exome=FALSE", that will analyze the WGS data.

Thanks, Mishu