SigProfilerMatrixGenerator creates mutational matrices for all types of somatic mutations. It allows downsizing the generated mutations only to parts for the genome (e.g., exome or a custom BED file). The tool seamlessly integrates with other SigProfiler tools.
Hi, the documentation for the "exome" flag states that if "exome=True", the matrix generator will "Downsample mutational matrices to the exome regions of the genome". If we are already using exome data, should we set this flag to True or False? I tried both and used SigProfilerExtractor, and it seems like the different signatures are extracted for each case, so not sure which flag to use.
Hi, the documentation for the "exome" flag states that if "exome=True", the matrix generator will "Downsample mutational matrices to the exome regions of the genome". If we are already using exome data, should we set this flag to True or False? I tried both and used SigProfilerExtractor, and it seems like the different signatures are extracted for each case, so not sure which flag to use.