Closed bzhang19 closed 1 year ago
Hi @bzhang19,
Thanks for reaching out. As explained in the COSMIC Mutational Signatures downloads website (https://cancer.sanger.ac.uk/signatures/downloads/), there is no renormalization available for the reference ID signatures, in contrast to SBS and DBS signatures. However, you can always extract de novo ID signatures from your GRCh38-aligned genomic data using SigProfilerExtractor.
I'll proceed to close this ticket as it's not related to our legacy SigProfilerSingleSample package, but happy to follow up over email (mdiazgay@health.ucsd.edu) if you have further questions.
Hello! Looking at the COSMIC website, the ID signatures are all derived from build 37. Is it possible to extract COSMIC ID signatures from build 38 vcfs? Thanks for your time!