AlexsLemonade / OpenPBTA-analysis

The analysis repository for the Open Pediatric Brain Tumor Atlas Project
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tp53 classifier plots 1/n #1151

Closed jharenza closed 3 years ago

jharenza commented 3 years ago

Purpose/implementation Section

What scientific question is your analysis addressing?

Adding manuscript plots for tp53 classifier module

What was your approach?

Added ggpubr-themed plots labeled with appropriate statistical tests.

- Distribution of TP53 expression across tp53 altered status (separate stranded/polyA)

tp53_expression_by_altered_status_stranded.png tp53_expression_by_altered_status_polya.png

- Distribution of scores across tp53 altered status by cancer predisposition - export these as separate plots by predisposition so they can be broken up for main/supplement
I chose LFS for now (Li Fraumeni Syndrome), as this is the perfect control due to germline P53 mutations being the mechanism of the predisposition syndrome. Can revisit whether we want additional plots in the next PR or so.

lfs_tp53_scores.png



#### What GitHub issue does your pull request address?
#1146 in part

### Directions for reviewers. Tell potential reviewers what kind of feedback you are soliciting.

#### Which areas should receive a particularly close look?
NA

#### Is there anything that you want to discuss further?
No

#### Is the analysis in a mature enough form that the resulting figure(s) and/or table(s) are ready for review?
yes

### Results

#### What types of results are included (e.g., table, figure)?
plots

#### What is your summary of the results?
NA, reran the module and exported cleaned up plots which were already a part of `05-tp53-altered-annotation.Rmd`

#### Reproducibility Checklist

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- [x] The dependencies required to run the code in this pull request have been added to the project Dockerfile.
- [x] This analysis has been added to continuous integration.

#### Documentation Checklist

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- [x] This analysis module has a `README` and it is up to date.
- [x] This analysis is recorded in the table in `analyses/README.md` and the entry is up to date.
- [x] The analytical code is documented and contains comments.

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jharenza commented 3 years ago

closing this - I realized I was reviewing one of @kgaonkar6 's branches when I updated this. new PR incoming.