What changes need to be made? Please provide enough detail for another participant to make the update.
Similar to the analyses performed to assess relationships between TP53 scores and telomerase, we are interested in determining whether there is an immune cell type which might predict better or worse prognosis for cancer types and/or molecular subtypes within a cancer group. In addition, we are interested in adding PDL1 (CD274) expression as a covariate, although based on the comment here, we don't expect to see this as a prognostic indicator.
Analysis suggestions:
Perform multivariate survival analysis using immune cell types (minus uncharacterized), PDL1 expression, and cancer group as covariates
Within each cancer group, perform survival analysis using immune cell types (minus uncharacterized), PDL1 expression, and molecular subtype as covariates (while acknowledging we may have low Ns here)
Cancer groups of interest:
Low-grade glioma astrocytoma
High-grade glioma astrocytoma
Ddiffuse midline glioma
Ependymoma
Medulloblastoma
Also, remove:
Unclassified immune cell type
What input data should be used? Which data were used in the version being updated?
quantiseq immune cell fractions
RNA expression
histologies file
When do you expect the revised analysis will be completed?
jharenza
commented
2 years ago
What analysis module should be updated and why?
survival-analysis
What changes need to be made? Please provide enough detail for another participant to make the update.
Similar to the analyses performed to assess relationships between TP53 scores and telomerase, we are interested in determining whether there is an immune cell type which might predict better or worse prognosis for cancer types and/or molecular subtypes within a cancer group. In addition, we are interested in adding PDL1 (CD274) expression as a covariate, although based on the comment here, we don't expect to see this as a prognostic indicator.
Analysis suggestions:
Cancer groups of interest:
Also, remove:
What input data should be used? Which data were used in the version being updated?
When do you expect the revised analysis will be completed?
?
Who will complete the updated analysis?
@sjspielman