AlexsLemonade / OpenPBTA-analysis

The analysis repository for the Open Pediatric Brain Tumor Atlas Project
Other
100 stars 67 forks source link

Removed unknown/unavailable resections from relevant survival models #1356

Closed sjspielman closed 2 years ago

sjspielman commented 2 years ago

This PR revisits two of the survival notebooks, immune and tp53_telomerase, which construct models using extent_of_tumor_resection. The models included unknown resections (denoted "Unavailable" or "Not reported" in the data), but these categories are wholly uninterpretable so they should not be included.

This PR updates the specific survival models and associated results where this predictor was included.

There is one particularly notable result change that I observed - the model with quantiseq cell type + fractions CD274 + extent of tumor resection now only converges for HGG, not MB.