This should require a YAP1 fusion for the call to be EPN, YAP1 and RELA fusions for a call to be EPN, RELA. Currently, it also considers other molecular markers and can call a tumor YAP1 positive without the YAP1 fusion.
What changes need to be made? Please provide enough detail for another participant to make the update.
jharenza
commented
2 years ago
What analysis module should be updated and why?
This should require a YAP1 fusion for the call to be EPN, YAP1 and RELA fusions for a call to be EPN, RELA. Currently, it also considers other molecular markers and can call a tumor YAP1 positive without the YAP1 fusion.
What changes need to be made? Please provide enough detail for another participant to make the update.
See above and this comment https://github.com/PediatricOpenTargets/OpenPedCan-analysis/pull/171#issuecomment-1116812050
Update the logic such that the fusions are required for those subtypes.
What input data should be used? Which data were used in the version being updated?
When do you expect the revised analysis will be completed?
Who will complete the updated analysis?