Closed sjspielman closed 1 year ago
In https://github.com/AlexsLemonade/OpenPBTA-analysis/pull/1660/commits/ec9cab75531de583e69f1443eb2f2c809edda7b0, I incorporated the tumor purity filtering function and re-ran the module. There were no diffs from re-running.
Closes #1628
This PR updates the
quanTIseq
module to assess to what extent key results (indicated in issue #1628) might change if we perform deconvolution only on tumors that pass a purity threshold.Punchline: Results are consistent, but I did identify a place where we might want to make a general revision in the manuscript regarding
quanTIseq
interpretations. Specifically, we reference HGGs broadly in this sentence, but only DMGs are plotted in the figure. So, we may just want to focus on talking about DMGs. https://github.com/AlexsLemonade/OpenPBTA-manuscript/blob/b0fdf6f24fe9c021f22e8b7da348708f68877ee5/content/03.results.md?plain=1#L283There are several key code changes:
Here is the rendered notebook! 03-quantiseq-at-threshold.nb.html.zip