We have some cellhash data (i.e. https://github.com/AlexsLemonade/ScPCA-admin/issues/203), but the current workflows do not support it. We need to add that support, with methods to be determined. This issue is for exploration of the options for cellhashing, in order to determine which methods to use/support.
Other methods are noted and linked in the: cellhashR repo https://github.com/BimberLab/cellhashR; I am not sure we necessarily want to use cellhashR directly (there seems to be big focus on QC and comparing methods, though a consensus method may not be bad), but there should be ideas there we can build from.
jaclyn-taroni
commented
2 years ago
We have some cellhash data (i.e. https://github.com/AlexsLemonade/ScPCA-admin/issues/203), but the current workflows do not support it. We need to add that support, with methods to be determined. This issue is for exploration of the options for cellhashing, in order to determine which methods to use/support.
Some quick notes/links on methods:
DropletUtils::hashedDropslooks pretty simple to implement, especially given our current focus on SCE objects, https://rdrr.io/github/MarioniLab/DropletUtils/man/hashedDrops.htmlOther methods are noted and linked in the:
cellhashRrepo https://github.com/BimberLab/cellhashR; I am not sure we necessarily want to usecellhashRdirectly (there seems to be big focus on QC and comparing methods, though a consensus method may not be bad), but there should be ideas there we can build from.