Closed saskiad closed 10 months ago
I would mention that FS units are thought to be inhibitory, including PV and SST interneurons. RS units are thought to be excitatory, but do include VIP interneurons.
I don't normally associate SST neurons with fast-spiking neurons. Many SST neurons don't have narrow action potentials.
According to the literature and the data I've seen they do. I can believe that not ALL classes of SST neurons have narrow action potentials, but definitely many do.
On Thu, Aug 17, 2023 at 4:48 PM Galen Lynch @.***> wrote:
I don't normally associate SST neurons with fast-spiking neurons. Many SST neurons don't have narrow action potentials.
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Well, faster than pyramidal neurons but my impression from the literature that sub 400 us is mostly PV+. Anna's paper in auditory cortex shows SST+ neurons have intermediate peak to trough times, while PV+ neurons have the shortest (https://www.jneurosci.org/content/40/18/3564/tab-figures-data). Patch recordings (e.g. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159120/figure/pbio-1001944-g001/) show similar longer SST+ APs compared to PV+. However, I'm not an expert.
Maybe given the diversity of PV+ interneurons and SST+ interneurons we could just say it's complicated but I've personally always assume people were talking about PV+ neurons when they say fast spiking interneurons.
The general assumption I've seen is that fast-spiking units are specifically PV+ (at least in cortex)