Running 7000+MAGs, no progress after Prodigal

[Burgersnow]

Hello, first of all thank you very much for this very useful tool. I'm having a little trouble reprocessing my data. I had 7000+ MAGs, and after executing commands in the form required by the software, no hmmsearch was performed for 3 days after prodigal ended, and no tmp_run_hmmsearch.sh was generated. It seems the command is stuck somewhere between prodigal and hmmsearch. But when I tested it with 10 MAGs, prodigal immediately followed with hmmsearch. When I used 1600 MAGs tests, it took 5 hours for prodigal to finish running hmmsearch. At this speed, more than 7,000 MAGs could run hmmsearch almost 24 hours after prodigal was completed. I don't know much about perl and wonder if this step between prodigal and hmmsearch takes so long (more than 3 days) when there are a lot of MAGs (7000+MAGs, about 18G in total) to process? Or do you have any other suggestions?

[ChaoLab]

METABOLIC would have problems in processing so many MAGs as we operated it before. Yes, it runs very slow and gets stuck. I will suggest you to run them separately, for example, run 2000 MAGs each time

[Burgersnow]

If I divide these 7000 MAGs into four groups and run the metabolic c.pl program respectively, how can I integrate these four groups of results together to draw metabolic sankey, functional network and other pictures?

[adityabandla]

Running into the same issue with 2000 MAGs

[LvbBo]

If I divide these 7000 MAGs into four groups and run the metabolic c.pl program respectively, how can I integrate these four groups of results together to draw metabolic sankey, functional network and other pictures?

Hi, I encountered the same problem. Have you solved this problem? If so, please tell me the details. Thanks!!!