Closed vanako closed 3 years ago
SIR model trained on 10 days of New York and California data from the COVID-19 pandemic (March 2020).
The published model is defined in the paper as two versions: with and without a reparameterization. The implementation in this collection has model dynamics defined in terms of a standard SIR model, but $\beta$ is calculated from the parameters in the PEtab parameter table as $\beta = \frac{R_0 \gamma}{N}$.
Table 1 in the original publication suggests that 10 days of data were used for training, which matches the implementation in this collection.
The model is generally easy to train, to produce a fit of similar quality to the paper. 1000 starts with SciPy L-BFGS-B were use to produce the optimized parameter vector (nominal values in the parameter table) and corresponding simulations.tsv
. However, even 10 starts will produce similarly good fits.
The paper uses difference equations for their simulation [1] of the ODE system, which may produce differences compared to ODE solvers typically used with SBML/PEtab.
Updated in #222
https://www.pnas.org/content/117/29/16732