bioc-issue-bot
commented
2 years ago Hi @Jfortin1
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The DESCRIPTION file for this package is:
Package: crisprDesign
Title: Comprehensive design of CRISPR gRNAs for nucleases and base editors
Version: 0.99.77
Authors@R: c(
person("Jean-Philippe", "Fortin", email = "fortin946@gmail.com", role = c("aut", "cre")),
person("Luke", "Hoberecht", email = "lukehob3@gmail.com", role = c("aut"))
)
Description:
Provides a comprehensive suite of functions to design and annotate CRISPR guide RNA (gRNAs) sequences. This
includes on- and off-target search, on-target efficiency scoring, off-target scoring, full gene and TSS
contextual annotations, and SNP annotation (human only). It currently support five types of CRISPR
modalities (modes of perturbations): CRISPR knockout, CRISPR activation, CRISPR inhibition,
CRISPR base editing, and CRISPR knockdown. All types of CRISPR nucleases are supported, including
DNA- and RNA-target nucleases such as Cas9, Cas12a, and Cas13d. All types of base editors are
also supported. gRNA design can be performed on reference genomes, transcriptomes,
and custom DNA and RNA sequences.
Depends: R (>= 4.2.0),
crisprBase (>= 0.99.15)
Imports:
AnnotationDbi,
BiocGenerics,
Biostrings,
BSgenome,
crisprBowtie (>= 0.99.8),
crisprScore (>= 0.99.24),
GenomeInfoDb,
GenomicFeatures,
GenomicRanges (>= 1.38.0),
IRanges,
Matrix,
MatrixGenerics,
methods,
S4Vectors,
stats,
utils,
VariantAnnotation
Suggests:
biomaRt,
BSgenome.Hsapiens.UCSC.hg38,
BSgenome.Mmusculus.UCSC.mm10,
BiocStyle,
crisprBwa (>= 0.99.7),
knitr,
rmarkdown,
Rbowtie,
Rbwa,
RCurl,
testthat
biocViews:
CRISPR,
FunctionalGenomics,
GeneTarget
License: MIT + file LICENSE
Encoding: UTF-8
RoxygenNote: 7.1.2
VignetteBuilder: knitr
BugReports: https://github.com/Jfortin1/crisprDesign/issues
URL: https://github.com/Jfortin1/crisprDesign
Jfortin1
nturaga
lshep
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