Closed zzhang23 closed 1 year ago
Hi @zzhang23
Thanks for submitting your package. We are taking a quick look at it and you will hear back from us soon.
The DESCRIPTION file for this package is:
Package: HiBED
Type: Package
Title: HiBED
Version: 0.99.0
Authors@R: c(person("Ze", "Zhang", role = c("cre", "aut"),
email = "ze.zhang.gr@dartmouth.edu"),
person(c("Lucas", "A."), "Salas", role = c("aut"),
email = "lucas.a.salas.diaz@dartmouth.edu"))
Description: Hierarchical deconvolution for extensive cell type resolution in the human brain
using DNA methylation. The HiBED deconvolution estimates proportions up to 7 cell
types (GABAergic neurons, glutamatergic neurons, astrocytes, microglial cells,
oligodendrocytes, endothelial cells, and stromal cells) in bulk brain tissues.
License: GPL-3
Encoding: UTF-8
LazyData: false
VignetteBuilder: knitr
biocViews: ExperimentData, Homo_sapiens_Data, Tissue, MicroarrayData, Genome, MethylationArrayData
RoxygenNote: 7.2.1
URL: https://github.com/SalasLab/HiBED
Imports: dplyr, FlowSorted.Blood.EPIC, tibble, FlowSorted.DLPFC.450k, minfi
Suggests: knitr, rmarkdown, FlowSorted.CordBlood.450k, testthat
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Hi Ze, @zzhang23 Thank you for your submission. See the review below. Best, Marcel
The package needs to make use of existing Bioconductor data representations
such as SummarizedExperiment
. Currently it only uses matrix. The
implementation code needs revision and unit test coverage should be increased.
BugReports
field.HiBED()
)data("HiBED_Libraries")
call in the vignette.
That is, evaluate the data
call in line 33 and remove from 46.print
.Installation
and Loading packages
sections..onLoad
function.@usage
section to the HiBED_Libraries
documentation as
@usage data("HiBED_Libraries")
BiocCheck
and adjust the syntax accordingly.|>
rather than %>%
to avoid the dependency.message
functionh
is character (see line 138 in HiBED_deconvolution.R
).GlobalEnv
and follow our recommendations in
https://contributions.bioconductor.org> covr::package_coverage()
HiBED Coverage: 1.37%
R/zzz.R: 0.00%
R/HiBED_deconvolution.R: 1.39%
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Hi Marcel, @LiNk-NY
Thank you for your review. I believe I have addressed your comments below
The package needs to make use of existing Bioconductor data representations such as SummarizedExperiment
. Currently it only uses matrix. The implementation code needs revision and unit test coverage should be increased.
I changed the matrices to the format of SummarizedExperiment
.
DESCRIPTION
- Add a
BugReports
field. Added.- Consider adding your ORCiD ID. Added.
NAMESPACE
- Looks good.
- Consider renaming the main function to the name of the package (i.e.,
HiBED()
)vignettes
- Consider including only one
data("HiBED_Libraries")
call in the vignette. That is, evaluate thedata
call in line 33 and remove from 46. Removed- Remove the redundant use of
- Organize your vignette to include
Installation
andLoading packages
sections. UpdatedR
- Remove the
.onLoad
function. Removed- Add a
@usage
section to theHiBED_Libraries
documentation as@usage data("HiBED_Libraries")
Added.- Please format the code so that it fits the 80 character width limit and remove uncommented code. Updated
- Run
BiocCheck
and adjust the syntax accordingly. Updated- Consider using native pipes
|>
rather than%>%
to avoid the dependency.dplyr
is imported so this should be fine.- Avoid evaluating large chunks of code within the
message
function Updated- Include the data type in the argument documentation as there are instances where
h
is character (see line 138 inHiBED_deconvolution.R
) Updated- Avoid using data from the
.GlobalEnv
and follow our recommendations in https://contributions.bioconductor.org New environment was created to store data.tests
- We strongly recommend that you increase coverage Updated
Please let me know if more things need to be addressed.
Best, Ze
Hi Ze, @zzhang23
Thank you for making those changes. It looks better.
The documentation does not indicate that SummarizedExperiment
is a possible input. Please adjust the function so that it can handle both matrix
and SummarizedExperiment
inputs (you may have to use assay
to extract the matrix
from the SummarizedExperiment
object).
It looks like line 164 in HiBED_deconvolution.R
is still looking for h
of character type. Please fix this or it will not run if the expected input is numeric.
Best, Marcel
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Hi Marcel, @LiNk-NY
Thank you for your time. I misunderstood some of your previous comments but now corrected them accordingly.
Thank you for making those changes. It looks better. The documentation does not indicate that
SummarizedExperiment
is a possible input. Please adjust the function so that it can handle bothmatrix
andSummarizedExperiment
inputs (you may have to useassay
to extract thematrix
from theSummarizedExperiment
object). I updated the function to allowSummarizedExperiment
as a possible input.It looks like line 164 in
HiBED_deconvolution.R
is still looking forh
of character type. Please fix this or it will not run if the expected input is numeric. I corrected h as a numeric variable.
Please let me know if more things are needed. Thanks.
Best, Ze
Hi Ze, @zzhang23
Sorry for the delay in getting back to you.
assay
function as mentioned previously?
E.g.,
HiBED_Libraries$Library_Layer1@assays@data@listData$counts
should be something like assay(HiBED_Libraries$Library_Layer1, "counts")
IlluminaHumanMethylation450kmanifest
to the Suggests
field if the code in the package does not directly need it. It can also be loaded conditionally whenever the function is run (with requireNamespace
). Best, Marcel
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Hi Marcel, @LiNk-NY
Thank you for your feedback. I have made changes accordingly.
- Can you please make use of the
assay
function as mentioned previously? E.g.,HiBED_Libraries$Library_Layer1@assays@data@listData$counts
should be something likeassay(HiBED_Libraries$Library_Layer1, "counts")
I have updated that in lines 56-62 in HiBED_deconvolution.R
.
- consider moving large data packages such as
IlluminaHumanMethylation450kmanifest
to theSuggests
field if the code in the package does not directly need it. It can also be loaded conditionally whenever the function is run (withrequireNamespace
).
I have moved IlluminaHumanMethylation450kmanifest
and IlluminaHumanMethylationEPICmanifes
to the Suggests
field.
Let me know if more changes are needed. Thanks a lot.
Best, Ze
Hi Ze, @zzhang23 Thank you for making those changes.
It seems that the package does not make use of IlluminaHumanMethylation450kmanifest
and IlluminaHumanMethylationEPICmanifest
. Do they need to be in the Suggests
field?
It seems to me that they can be removed.
Best, Marcel
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Hi Marcel, @LiNk-NY
Thanks for the suggestion.
IlluminaHumanMethylation450kmanifest
is actually essential to load our example data but IlluminaHumanMethylationEPICmanifest
is redundant. We kept IlluminaHumanMethylation450kmanifest
and removed IlluminaHumanMethylationEPICmanifest
.
Let me know if more changes are needed.
Best, Ze
Hi Ze, @zzhang23
Thank you for the update and for making those changes.
Please address the NOTE
from R CMD check
at your earliest convenience.
* checking R code for possible problems ... NOTE
HiBED_deconvolution: no visible global function definition for ‘data’
HiBED_deconvolution: no visible binding for global variable ‘Sum’
Undefined global functions or variables:
Sum data
Consider adding
importFrom("utils", "data")
to your NAMESPACE file.
Best regards, Marcel
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Hi Marcel, @LiNk-NY
Please address the
NOTE
fromR CMD check
at your earliest convenience. I believe I have addressed theNOTE
.
Thank you!
Best, Ze
Thank you for making those changes. The package has been accepted. Best regards, Marcel
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