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Biogen-Inc / tidyCDISC

Demo the app here: https://bit.ly/tidyCDISC_app
https://biogen-inc.github.io/tidyCDISC/
GNU Affero General Public License v3.0
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[Question] Do the confidence intervals address repeated measures? #250

Closed adrianolszewski closed 6 months ago

adrianolszewski commented 6 months ago

Dear Authors, First of all I wanted to say I admire your work and congratulate you an excellent idea for the exploration of CDISC datasets!

I have question about these CIs: obraz

Are they just raw, "naive" unpaired CI for the mean, or do you maybe employ the MMRM or LMM (if so, then how parameterized) to reflect the fact they come from observations repeated over time (so likely correlated within-patient)? In the free time I will look at the code, but just wanted to ask quickly in the move.

aclark02-arcus commented 6 months ago

Hi @adrianolszewski. Thanks for opening an issue to ask this question. I've identified the code that produces the 95% CI's for the line plot module here:

https://github.com/Biogen-Inc/tidyCDISC/blob/f41ed77e1fd0df86ad95ec75dbb01efa565d00af/R/mod_popExp_line.R#L204

As you can see, it leverages a "naive" approach.