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BioinfoUNIBA / REDItools

REDItools are python scripts to investigate RNA editing at genomic scale.
MIT License
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Differential RNA editing analysis using REDItools2 #19

Open Lei-Guo opened 1 year ago

Lei-Guo commented 1 year ago

Thanks for developing REDItools2. It’s a nice tool to use. I’ve got some questions about using the tool.

I have 2 groups with 3 replicates in each group. I identified RNA editing events in each sample (replicate) using REDItools2. REDItools2 identified ~300,000 AG editing events in each sample.

Now I want to do differential RNA editing analysis between the 2 groups. I noticed REDItools2 doesn’t provide differential RNA editing analysis. I tried to use the same method for DE analysis (gene) but found there is little overlap of editing events identified among samples. Among ~300,000 AG editing events, there are only ~8000 common editing events among the 6 samples across the 2 groups.

Could you please advise me on how to do differential analysis with the REDItools2 results? Thank you so much.

yr542 commented 8 months ago

REDItools Version 1 has a get_DE_events.py located here ( https://github.com/BioinfoUNIBA/REDItools/blob/master/accessory/get_DE_events.py ) will that help?