search

Braden-Griebel / imatpy

Python implementation of iMAT algorithm for integration of gene expression data with metabolic modeling.
https://imatpy.readthedocs.io/en/latest/index.html
1 stars 0 forks source link

Add MOMA #1

Open Braden-Griebel opened 9 months ago

Braden-Griebel commented 9 months ago

Add the minimization of metabolic adjustment (MOMA) algorithm. The algorithm:

  1. Finds a solution to the wildtype, flux distribution w
  2. Formulates a problem minimizing the euclidean distance to that flux distribution, subject to the same constraints (with some modified, or added such as an additional gene knock out).
  3. Solve this problem, finding a minimally perturbed flux distribution.