Scope of work for nested birdcage prototype

[BenInglis]

We need to define a scope of work in order to get the project with Ken off the ground. Here are the instructions from Procurement Services:

Statement of work addresses in detail:  “What” is wanted  “When” it is wanted  “Where & How” it should be delivered  “How” should it be packaged (if applicable)  “How, When, and Where” it should be inspected/tested and accepted or reviewed indicating it meets requirements  Who (department or supplier/vendor) is responsible for certain activities (such as certain furnished materials/services, training, follow-on upgrades, maintenance and spare parts replenishment)  If there will be progress reviews and progress reporting, and if so, “How, When, Where, and by Whom”  Specialized personnel which may be required  Other activities that provide a complete description of the requirements to eliminate misunderstanding of what is required by each side of the transaction

Statement of Work Guidelines.pdf

[BenInglis]

"What" - first draft

It is proposed that a prototype birdcage coil be designed and built with sufficient room for head of a human subject and free placement of TMS probe. The coil being considered is a nested birdcage that will have the potential of parallel acceleration in the z direction. The nested birdcage coil design will comprise three independent receive coils, or "nested" birdcages. The coil form will allow for 30 cm internal diameter. Length is to be determined. The coil will have on-coil preamps, system connector with cable (and cable traps), and Siemens coil file. Include RF coil enclosure, or shall BIC construct as needed?

[kbradshaw9]

Couple of questions for clarification. If we have on-coil preamps, what is the RF coil enclosure? Does it contain quadrature combination and point connection for all coils? Although we don't know all the challenges we will encounter with this prototype with its new coil configuration, we should allow for "improvements" as we go along. We will not know everything to plan for. Making smaller coils are not necessarily easier but making really large coils have issues too. Will the 30 cm ID allow for the TMS probe to be inserted without restriction of placement? I know that normal head coils (surface arrays) use about 25 cm for a close fit.

[BenInglis]

Re. the enclosure, my suggestion is to make the initial prototype as simple as possible, even with "naked" conductive elements if needed, and test only on phantoms. A modified prototype (version 1.2) could have an enclosure, otherwise I would wait for v2.0, a full sized coil, to build an enclosure. I see v1.0 as a test coil only, not for human use, not for use with a TMS coil, whereas v2.0 would be suitable for testing on a human and, if desired, large enough to permit testing with a TMS coil. If we break the project down then we can more easily determine milestones for billing purposes.

[kbradshaw9]

I remember our discussing this now. I agree to forgo the enclosure for the first prototype since it will be used only with phantoms.

On Mar 8, 2016, at 11:10 AM, BenInglis notifications@github.com wrote:

Re. the enclosure, my suggestion is to make the initial prototype as simple as possible, even with "naked" conductive elements if needed, and test only on phantoms. A modified prototype (version 1.2) could have an enclosure, otherwise I would wait for v2.0, a full sized coil, to build an enclosure. I see v1.0 as a test coil only, not for human use, not for use with a TMS coil, whereas v2.0 would be suitable for testing on a human and, if desired, large enough to permit testing with a TMS coil. If we break the project down then we can more easily determine milestones for billing purposes.

— Reply to this email directly or view it on GitHub https://github.com/Brain-Imaging-Center/Nested-Birdcage-Coil/issues/3#issuecomment-193896380.

[BenInglis]

Great. And the first prototype would be only three elements since we decided that two elements wouldn't be sufficient to fully test the ideas. Then the second prototype, which would be the first coil to have an enclosure and be suitable for testing with a human, would likely have four elements. We would build in flexibility, and perhaps specify "not less than three, up to six" in order to satisfy the total z direction coverage we would need for a typical adult brain.

[BenInglis]

Draft scope of work with milestones:

Milestone 1. Design & construct prototype nested birdcage coil with three elements, size TBD but not necessarily human head sized or sufficiently large to accommodate a TMS coil. No enclosure is required, the coil will be tested only with phantoms. The coil will have on-coil preamps, system connector with cable (and cable traps), and Siemens coil file. Estimated time to complete: 6 months.

Milestone 2. Install and test the prototype nested birdcage on the Berkeley Trio scanner. Tests to include the ability to acquire unaccelerated and simultaneous multislice (SMS) EPI images from phantoms using a variety of existing pulse sequences. Estimated time to complete: 6 months.

Milestone 3. Design & construct a full-sized nested birdcage coil with between four and six elements, the exact number being determined based on the results from the prototype and the target z direction coverage. The inner diameter will be 30 cm, final length TBD but with z receive field sufficient to cover an adult human brain. The coil will have an RF enclosure suitable for testing on selected human volunteers. The coil will have on-coil preamps, system connector with cable (and cable traps), and Siemens coil file. Estimated time to complete: 6 months.

Milestone 4. Install and test the full-sized nested birdcage on the Berkeley Trio scanner. Tests to include the ability to acquire unaccelerated and simultaneous multislice (SMS) EPI images from phantoms and normal human volunteers using a variety of existing pulse sequences, and tests of the existing MagPro TMS system inside the nested birdcage with and without human volunteers. Estimated time to complete: 9 months.

[kbradshaw9]

Draft scope of work with milestones:

Milestone 0. Setup of lab and acquisition of material for future designs and construction. Based upon a preliminary design, plastic formers, capacitors, inductors, PIN diodes, RF chokes, preamps, and system cables must be ordered and received. Acquisition will extend into Milestone 1, but purchasing of the parts may have to be in cash/credit card requiring prepayment for this milestone. Estimated time to complete: 2-3 months.

Milestone 1. Design & construct prototype nested birdcage coil with three elements, size TBD but not necessarily human head sized or sufficiently large to accommodate a TMS coil. No enclosure is required, the coil will be tested only with phantoms. The coil will have on-coil preamps, system connector with cable (and cable traps), and Siemens coil file. Estimated time to complete: 6 months.

Milestone 2. Install and test the prototype nested birdcage on the Berkeley Trio scanner. Tests to include the ability to acquire unaccelerated and simultaneous multislice (SMS) EPI images from phantoms using a variety of existing pulse sequences. Estimated time to complete: 6 months.

Milestone 3. Design & construct a full-sized nested birdcage coil with between four and six elements, the exact number being determined based on the results from the prototype and the target z direction coverage. The inner diameter will be 30 cm, final length TBD but with z receive field sufficient to cover an adult human brain. The coil will have an RF enclosure suitable for testing on selected human volunteers. The coil will have on-coil preamps, system connector with cable (and cable traps), and Siemens coil file. The coil will need to be subjected to the safety testing required by Siemens and FDA. Estimated time to complete: 6 months.

Milestone 4. Install and test the full-sized nested birdcage on the Berkeley Trio scanner. Tests to include the ability to acquire unaccelerated and simultaneous multislice (SMS) EPI images from phantoms and normal human volunteers using a variety of existing pulse sequences, and tests of the existing MagPro TMS system inside the nested birdcage with and without human volunteers. Estimated time to complete: 9 months.

[danshel]

Hi Ken and Ben

Sorry I have been out the loop on this. What you have written looks good to me: Get something that we can test within a year before proceeding to full project. Anything I can do at this point to assist with procurement?

Cheers, Daniel (Back in the loop.)

On Tue, Mar 15, 2016 at 9:49 AM, kbradshaw9 notifications@github.com wrote:

Draft scope of work with milestones:

Milestone 0. Setup of lab and acquisition of material for future designs and construction. Based upon a preliminary design, plastic formers, capacitors, inductors, PIN diodes, RF chokes, preamps, and system cables must be ordered and received. Acquisition will extend into Milestone 1, but purchasing of the parts may have to be in cash/credit card requiring prepayment for this milestone. Estimated time to complete: 2-3 months.

Milestone 1. Design & construct prototype nested birdcage coil with three elements, size TBD but not necessarily human head sized or sufficiently large to accommodate a TMS coil. No enclosure is required, the coil will be tested only with phantoms. The coil will have on-coil preamps, system connector with cable (and cable traps), and Siemens coil file. Estimated time to complete: 6 months.

Milestone 2. Install and test the prototype nested birdcage on the Berkeley Trio scanner. Tests to include the ability to acquire unaccelerated and simultaneous multislice (SMS) EPI images from phantoms using a variety of existing pulse sequences. Estimated time to complete: 6 months.

Milestone 3. Design & construct a full-sized nested birdcage coil with between four and six elements, the exact number being determined based on the results from the prototype and the target z direction coverage. The inner diameter will be 30 cm, final length TBD but with z receive field sufficient to cover an adult human brain. The coil will have an RF enclosure suitable for testing on selected human volunteers. The coil will have on-coil preamps, system connector with cable (and cable traps), and Siemens coil file. Estimated time to complete: 6 months.

Milestone 4. Install and test the full-sized nested birdcage on the Berkeley Trio scanner. Tests to include the ability to acquire unaccelerated and simultaneous multislice (SMS) EPI images from phantoms and normal human volunteers using a variety of existing pulse sequences, and tests of the existing MagPro TMS system inside the nested birdcage with and without human volunteers. Estimated time to complete: 9 months.

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https://github.com/Brain-Imaging-Center/Nested-Birdcage-Coil/issues/3#issuecomment-196918745

[kbradshaw9]

I needed to add one more activity to Milestone 3. Because we plan to use the coil developed in Milestone 3 in the human testing in Milestone 4, I will need to do the safety testing that is normally done for FDA. This essentially is heat testing. If I do everything right I should not have any problems but it can take significant time on the scanner and then if there are issues there will need to be some changes.

[danshel]

Hi Ken

We have a Fluke 561 HVACPro IR thermometer which also has a thermocouple input connector available. Will that work?

Cheers, Daniel

On Mon, Mar 21, 2016 at 4:56 PM, kbradshaw9 notifications@github.com wrote:

I needed to add one more activity to Milestone 3. Because we plan to use the coil developed in Milestone 3 in the human testing in Milestone 4, I will need to do the safety testing that is normally done for FDA. This essentially is heat testing. If I do everything right I should not have any problems but it can take significant time on the scanner and then if there are issues there will need to be some changes.

— You are receiving this because you commented. Reply to this email directly or view it on GitHub https://github.com/Brain-Imaging-Center/Nested-Birdcage-Coil/issues/3#issuecomment-199544222

[kbradshaw9]

Daniel,

Thermocouples use wire connection which can be problematic in the field. I have used IR probes before but they are not as precise as the fiber optic thermal probes.

--ken

[danshel]

Could you give me a link to a fiber optic probe that you think is acceptable?

On Tue, Mar 22, 2016 at 10:53 AM, kbradshaw9 notifications@github.com wrote:

Daniel,

Thermocouples use wire connection which can be problematic in the field. I have used IR probes before but they are not as precise as the fiber optic thermal probes.

--ken

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[kbradshaw9]

Daniel,

I have primarily used Neoptix (http://www.neoptix.com/t1-sensor.asp) but have had some experience with Opsens (https://opsens-solutions.com/products/fiber-optic-temperature-sensors/) also. We don't have to use the premium product either but the probes can be fragile so I try to use the better probes.

--ken

[RickRedfern]

Ken,

Do we need multiple channels or will a single probe suffice??

Rick

On Tue, Mar 22, 2016 at 12:39 PM, kbradshaw9 notifications@github.com wrote:

Daniel,

I have primarily used Neoptix (http://www.neoptix.com/t1-sensor.asp) but have had some experience with Opsens ( https://opsens-solutions.com/products/fiber-optic-temperature-sensors/) also. We don't have to use the premium product either but the probes can be fragile so I try to use the better probes.

--ken

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[kbradshaw9]

It will just take more time if we are limited to one channel. The testing can take up to 39 minutes for one temperature test. Multiple that by the number of channels which may have several sensitive temperature producing points. It can see why multiple sensors help. --Ken

On Mar 22, 2016, at 2:16 PM, RickRedfern notifications@github.com wrote:

Ken,

Do we need multiple channels or will a single probe suffice??

Rick

On Tue, Mar 22, 2016 at 12:39 PM, kbradshaw9 notifications@github.com wrote:

Daniel,

I have primarily used Neoptix (http://www.neoptix.com/t1-sensor.asp) but have had some experience with Opsens ( https://opsens-solutions.com/products/fiber-optic-temperature-sensors/) also. We don't have to use the premium product either but the probes can be fragile so I try to use the better probes.

--ken

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