Closed davebridges closed 9 years ago
Ok! I can do that!
Quynh T. Tran, PhD
On Jun 21, 2015, at 9:57 AM, Dave Bridges notifications@github.com<mailto:notifications@github.com> wrote:
For the response letter, Id like to state something along the lines of "based on our design we would have been able to assign significance to XXX% of genes that were altered by 50% or more (q=0.05)" Basically a sense of the power (without adjusting for age etc). Could you do a quick calculation. I want to do this as part of the argument that its worthwhile to mention genes that weren't quite significant.
— Reply to this email directly or view it on GitHubhttps://github.com/BridgesLab/CushingAcromegalyStudy/issues/62.
We have 23% power in detecting the target effect size of 1.5 (50% change in expression). The arguments are as follow:
These information can be found in the power-analysis script.
For the response letter, Id like to state something along the lines of "based on our design we would have been able to assign significance to XXX% of genes that were altered by 50% or more (q=0.05)" Basically a sense of the power (without adjusting for age etc). Could you do a quick calculation. I want to do this as part of the argument that its worthwhile to mention genes that weren't quite significant.