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BuildACell / txtlsim

Cell-free expression modeling toolbox for MATLAB
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Update documentation with info on numerical stability issues #35

Open vipulsinghal02 opened 7 years ago

vipulsinghal02 commented 7 years ago

Tools/guidelines for dealing with numerical instability (comes up a lot especially during parameter estimation)

murrayrm commented 7 years ago

Is this related to issue #36?

vipulsinghal02 commented 7 years ago

@murrayrm

These are both numerical stability issues, but are different. Here I am referring to the numerical instability that occurs because the parameters in the model might be separated by too many orders of magnitude, but in issue #36 we are referring to the numerical problems of trying to simulate transcription with stoichiometric coefficients of 600 in front of the nucleotide species.

I think since these problems both fall under the banner of numerical issues, I am adding the documentation of that issue to this one, and closing it.