CDCgov / NCHHSTP-DTBE-Varpipe-WGS

This repository contains an analysis pipeline developed to characterize WGS output
Apache License 2.0
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Only count paired-end overlaps once for depth #16

Open schorlton opened 10 months ago

schorlton commented 10 months ago

Samtools depth now has the functionality to only count overlaps in paired-end reads once. The community seems to think this is a more correct calculation of depth: https://bioinformatics.stackexchange.com/questions/5427/double-counting-coverage-of-overlapped-read-pairs. This PR enables this capability.