After network modules are identified the 'average signal profile' can be identified by calculating the modules eigengene. It would be a handy addition to investigate the structure of module.
Specifically, we define the module eigengene as the first right-singular vector of the standardized module expression data (Methods, Eq. 29). - Langfelder and Horvath, 2007, BMC
Notes:
A singular value decomposition is required. Whether a statistics library depedency makes sense is open to debate.
A standardization may be necessary.
After that, the eigengene may need to be inverted, depending on the correlations of most of the elements in it.
The orientation of the eigengene is solely determined by the orientation of the first row of the matrix
After network modules are identified the 'average signal profile' can be identified by calculating the modules eigengene. It would be a handy addition to investigate the structure of module.
Notes: