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Campbell-Muscle-Lab / PyMyoVent

PyMyoVent is computer code that simulates an idealized ventricle pumping blood around a single circulation.
http://Campbell-Muscle-Lab.github.io/PyMyoVent/index.html
BSD 3-Clause "New" or "Revised" License
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Growth module is not robust #17

Closed HosseinSharifii closed 3 years ago

HosseinSharifii commented 3 years ago

There is something wrong that the growth module does not reach to steady state solution. It can be either gain factors of the growth module that the concentric and eccentric growth are competing each other, or it can be the effect of baroreceptor.

As the wall thickness increases, the active force decreases. But on the other side the baroreceptor is increasing the contractile force and deviate the active force from its set point in growth module.

Potential solution: reduce the gain factor for k_1 and k_on in the baroreceptor, so the the interaction of growth and baroreceptor module could reach to a balance.

Hossein will investigate this.

kenatcampbellmusclelab commented 3 years ago

@HosseinGit Good catch. Let's discuss at an upcoming meeting. My recollection is that the growth module looked pretty robust in some of your earlier simulations. Perhaps there is a slow creep over time?