Fix BA1 hover text

[kilodalton]

Currently BA1 hover text is the same as BS1.

@wrightmw says it should be: "Allele frequency greater than 5% in a population database"

[kilodalton]

@wrightmw @selinad Does this look right?

BA1:

BS1:

[selinad]

Looks great. Thx @kilodalton.

(@wrightmw I assume you like "a database" better...)

[kilodalton]

For reference.

The (new) current hover text for all:

• BA1: "Allele frequency greater than 5% in a population database"
• BS1: "MAF is too high for disorder"
• BS2: "Observation in controls inconsistent with disease penetrance"
• BS3: "Well-established functional studies show no deleterious effect"
• BS4: "Nonsegregation with disease"
• BP1: "Missense in gene where only truncating cause disease"
• BP2: "Observed in trans with a dominant variant"
• BP3: "In-frame indels in repeat w/out known function"
• BP4: "Multiple lines of computational evidence suggest no impact on gene /gene product"
• BP5: "Found in case with an alternate cause"
• BP6: "Reputable source w/out shared data = benign"
• BP7: "Silent variant with non predicted splice impact"
• PP1: "Cosegregation with disease in multiple affected family members"
• PP2: "Missense in gene with low rate of benign missense variants and path. missenses common"
• PP3: "Multiple lines of computational evidence support a deleterious effect on the gene /gene product"
• PP4: "Patient's phenotype or FH highly specific for gene"
• PP5: "Reputable source = pathogenic"
• PM1: "Mutational hot spot or well-studied functional domain without benign variation"
• PM2: "Absent in population databases"
• PM3: "For recessive disorders, detected in trans with a pathogenic variant"
• PM4: "Protein length changing variant"
• PM5: "Novel missense change at an amino acid residue where a different pathogenic missense change has been seen before"
• PM6: "De novo (without paternity & maternity confirmed)"
• PS1: "Same amino acid change as an established pathogenic variant"
• PS2: "De novo (paternity and maternity confirmed)"
• PS3: "Well-established functional studies show a deleterious effect"
• PS4: "Prevalence in affecteds statistically increased over controls"
• PVS1: "Predicted null variant in a gene where LOF is a known mechanism of disease"

[wrightmw]

@selinad ...yeah, it was a last minute re-jig...I thought that 'some databases' implied it had to be in more than one databases, whereas for the rule to apply it only has be to found above 5% in one of the databases

[selinad]

It works. They'll let us know if it's too specific :). Thx!

[wrightmw]

BA1 hover text is correct now.

[selinad]

Looks great - thx!

[kilodalton]

Included in last release (R7alpha2). Nice job and thanks for your hard work.