Clinical-Genomics / chanjo2

Persistent coverage analysis tool using the d4 format
https://clinical-genomics.github.io/chanjo2/
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Include all transcripts in report and genes overview. #363

Open northwestwitch opened 1 month ago

northwestwitch commented 1 month ago

When I originally started developing chanjo2 I kind of copied the behavior of chanjo -> Include in stats onlt transcripts associated with mRNA. For instance the POT gene has several transcripts:

image

But only the first 2 will be used in the report/genes overview:

image

Now I wonder if it's case to change and include all transcripts. This will slow down reports, especially those with many genes, but they'll be more informative for sure

NOTE that all transcripts are included when creating the gene overview page

Jakob37 commented 1 month ago

Just speaking for Lund. I don't think the geneticists here in Lund generally would be interested in all transcripts. The reverse, I think they would (generally) prefer just the MANE transcript subset, to focus computational time and attention on what matters for them.

But might be a good idea for others!

What do you think about having this somehow configurable? Such that a user can select which set of transcripts is of interest.

northwestwitch commented 1 month ago

What do you think about having this somehow configurable? Such that a user can select which set of transcripts is of interest.

That's a good idea. I'll ask our clinicians this week and we'll see. But perhaps we keep this for next release. I'd really like to have the upcoming one ready and out after merging #361, so we'll something usable in production.

Jakob37 commented 1 month ago

What do you think about having this somehow configurable? Such that a user can select which set of transcripts is of interest.

That's a good idea. I'll ask our clinicians this week and we'll see. But perhaps we keep this for next release. I'd really like to have the upcoming one ready and out after merging #361, so we'll something usable in production.

Sounds very good 👌