Update all the things

[benfoley]

Update Flask & Jinja (will probably require modifying other Nic's nifty blueprints) Should then be able to remove these from pyproject

• MarkupSafe = "2.0.1"
• itsdangerous = "2.0.1"

Update node & change version specified in gui packages.json

[benfoley]

closed with #336 and #337