Aspects of the project that you find fascinating:
-- Investigating how differential histone expression might relate to cancer prognosis is a unique and interesting way to take an exciting concept that we’ve covered in class (histone modification and epigenetics) and apply it to an important field of active research.
-- I’ll be curious to see if there are trends where certain histone variants are expressed in cancers of certain tissues (for example, do all lung cancers express a similar histone variant?).
-- The plots you’ve already generated are really well-done, and I look forward to seeing them all come together in your final project.
Questions you have about the approach or results:
-- Are the expression analysis data based on single-cell RNAseq or bulk RNAseq of the histone variants?
-- What exactly is a Kaplan-Meier survival analysis?
Suggestions on next steps, project organization, etc.
-- Consider providing a list (maybe in a markdown file) of all of the histone variants you’re investigating, so someone looking at your repository can very quickly and easily see how extensive your analysis is.
-- If possible, I think editing the README.md file for the repository to include all the information provided in your “Quantitative_Biology_Project_Proposal.md” file would help with visualizing the project as a whole as soon as someone opens your repository.
-- Your plots are really spectacular! I can’t wait to see how everything turns out.
Aspects of the project that you find fascinating: -- Investigating how differential histone expression might relate to cancer prognosis is a unique and interesting way to take an exciting concept that we’ve covered in class (histone modification and epigenetics) and apply it to an important field of active research. -- I’ll be curious to see if there are trends where certain histone variants are expressed in cancers of certain tissues (for example, do all lung cancers express a similar histone variant?). -- The plots you’ve already generated are really well-done, and I look forward to seeing them all come together in your final project.
Questions you have about the approach or results: -- Are the expression analysis data based on single-cell RNAseq or bulk RNAseq of the histone variants? -- What exactly is a Kaplan-Meier survival analysis?
Suggestions on next steps, project organization, etc. -- Consider providing a list (maybe in a markdown file) of all of the histone variants you’re investigating, so someone looking at your repository can very quickly and easily see how extensive your analysis is. -- If possible, I think editing the README.md file for the repository to include all the information provided in your “Quantitative_Biology_Project_Proposal.md” file would help with visualizing the project as a whole as soon as someone opens your repository. -- Your plots are really spectacular! I can’t wait to see how everything turns out.