Establish the WT profiles for Cell Painting data

[sverchkov]

Which wells can be considered WT profiles as a baseline for establishing the "change in morphology" phenotype?

It looks like the ORF negative controls and the CRISPR no-guide and non-targeting perturbations are good candidates.

[sverchkov]

Methods for establishing the phenotype:

• [x] Statistical test of correlations
• [x] Hierarchical clustering

[sverchkov]

We've established a binary definition based on counts of features outside of 2 standard deviations of controls