I don't know how reliable I2C bus is on bigger layouts, but I'm afraid not perfect. What about use UART TTL or even better RS485. As end point could be used nanos or so.
Alternatives or workarounds
Address of nano could be in EEPROM, more addresses then with PCF PWM or PCA i/o expanders.
Problem/idea statement
I don't know how reliable I2C bus is on bigger layouts, but I'm afraid not perfect. What about use UART TTL or even better RS485. As end point could be used nanos or so.
Alternatives or workarounds
Address of nano could be in EEPROM, more addresses then with PCF PWM or PCA i/o expanders.
Additional context
No response