Help investigator design feature study using eeDAP

[brandon-gallas]

Team from UK National Health System (NHS)

• Darren Treanor [link to NCIPhub profile or other?]
• Bethany Williams
• Imogen Wilson

  Team from US Food and Drug Administration (FDA)

• Brandon Gallas Profile, GitHub Profile
• Qi Gong

  What's the plan?

The plan is to design a feature study to compare two different displays for use in digital pathology. The study is in the spirit of the mitotic counting study described in Brandon's 2016 Pathology Informatics Summit presentation. The NHS team will consider the task to be performed. Here's some characteristics for the task.

• It should be based on a single FOV.
• It should be objective detection, classification, enumeration, quantification
• It should be based on tissue sections that can be sourced according to reproducible inclusion and exclusion criteria.
• It should challenge the imaging modality in terms of resolution, depth of field, or color (others?).
• Other characteristics?

  Draft Timeline

• Q4 2016, Set up an eeDAP system at NHS.
• Q1 2017, Create study protocol.
• Q2 2017, Prepare slides, images, and eeDAP input files.
• Q3 2017, Collect data.
• Q4 2017, Analyze data.

  Getting started

Please refer to the front page of the eeDAP GitHub project: https://github.com/DIDSR/eeDAP

The README on the front page contains links to the manual and software releases, as well as related references and resources. The front page also contains the top-level directory of the source code repository. Check it out.

[brandon-gallas]

NHS Hardware

• Microscope:
  • Leica DM4000 Brochure
  • The NHS microscope should work as long as it has a camera port for simultaneous viewing with the eyepiece and a motorized stage can be mounted.
  • There is automation of microscope features (illumination). We should discuss whether or not we want such automation.
• Camera:
  • Make? and Model?
  • According to the microscope brochure, the camera interface is firewire.
  • FDA has used a firewire camera FDA cameras used
  • The NHS camera should work.
• Stage and Controller:
  • Prior H101A stage Data sheet
  • ProScan III controller with Joystick Operating manual
  • FDA has a similar stage FDA stages and controllers used
  • The NHS stage and controller should work.