DIDSR / iMRMC

iMRMC: Software to do multi-reader multi-case analysis of reader studies
http://didsr.github.io/iMRMC/
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MLE analysis Negative Variance #127

Closed qigongFDA closed 6 years ago

qigongFDA commented 6 years ago

In some cases, the MLE analyses Var(A-B) are negative. We faced this problem on small reader size and big case size input file.

We use R to write a script. It calculate Var(A-B) by Var(A) + Var(B), and use this Var(A-B) to estimate other statistic results.