Closed Daniel-Mietchen closed 5 years ago
Program skeleton: https://gidi.virginia.edu/2019-gidi-symposium
Registration now open: https://gidi.virginia.edu/2019-gidi-symposium-registration-form . I just registered.
Apparently, there was a Zika brewing session in November 2018. Need to find out details.
Now lightning talks (none of the slides are available)
Richard Karl Deang, anthropologist on peer counseling around HIV prevention
Now Peter Kasson on cases where moderate pre-existing immunity can worsen outcomes due to cross-reactions, e.g. between Zika and Dengue
Scholia profiles updated:
Missing from the first round of lightning talks: Volkan Koseoglu on the extracellular lifestyle of an intracellular pathogen
Coffee break
Now onto the keynote by Carolyn Reynolds, a UVA alumna: What the World (Still) Needs to Do to Prevent the Next Pandemic
Now her priorities derived from those experiences:
In closing, she makes multiple comparisons between preparedness for military and pandemic threats, especially in Virginia with its strong military presence/ roots/ culture.
Closes off with reference to the 1918 pandemic
Now on to the 2nd round of Lightning talks
No results shown.
Martin Wu, Resistance prediction of Clostridium difficile infection
In clinical practice, anibiotic resistance is not routinely tested, even though antibiotic failure rate is high (ca. 1/3) ==> goal: rapid test for anibiotic resistance in C. difficile based on nanopore sequencing bacterial DNA from stool samples (of which they have 103 as of now)
Nice slide with bacterial composition in the stool of one patient, including 0.14 percent C. difficile. Top one was Akkermansia muciniphila.
Needs info on the genes that are involved in conferring resistance.
Signs of emerging resistance to Vancomycin and Fidaxomicin (which targets RNA polymerase).
Gregory Maddon: Cost of overtesting and overdiagnosing of C. difficile antibiotic resistance
No FDA-approved test to diagnose C. difficile infection (as opposed to colonization by C. difficile). Conventional tests are PCR-based and results not very reliable.
PCR Cycle threshold as a predictor of C. difficile toxin levels
Md Amzad Hussein on Impact of Community Clinics on Health outcome, based on a field study in Bangladesh
country-wide aim in Bangladesh: for every 6000 inhabitants, have a health clinic in walking distance
the policy around that has changed three times around this, thereby constituting a "natural experiment" in terms of introducing/ phasing out community clinics
those community clinics are very simple (may be just 2 rooms plus a lavatory) but serve in access of 100 million people in the country
Kate McManus: HIV and health insurance (in the US)
Now Jason Papin on antibiotic resistance "in the wild" (i.e. as opposed to very controlled laboratory conditions)
Angelina Angelucci on inflammasomes in congenital Zika virus infection
mouse model
measuring IL-1β and IL-6 using ELISA in brain and placenta
can see inflammation through brain morphological changes
they're planning to look at Caspase 1 and Gasdermin D next, which are at the beginning and end of the inflammasome pathway, respectively
Now Volkan Köseoğlu on the extracellular lifestyle of an intracellular pathogen, who was originally (on paper) scheduled in the first session
Shigella infections and IcsA
Actin based motility, bile salts, biofilm formation in small intestine and colon
Q: Does Shigella develop biofilms under flow? A: Yes
Q: Does IcsA have a role in this biofilm formation? A:
Reminds me of the biofilm MRI my colleagues did back at IBMT
as per https://twitter.com/GIDIuva/status/1075008121557393408 . Details forthcoming.