Genetic

[Darviridis]

I am very interested in the development of human genetics. Genome editing, stopping aging at the genetic level and genetic modification.

USSR Genetic

I was surprised when I learned that in the USSR at the turn of 1930-1940, during the Great Terror, a number of prominent geneticists were arrested and most of the employees of the apparatus of the Central Committee of the All-Union Communist Party of Bolsheviks who oversaw genetics, many were shot or died in prisons. In 1948, Lysenko declared the scientific findings of Western geneticists to be pseudoscience, linking them to the propaganda of eugenics and racism. Genetics was outlawed and the ban was only lifted in 1964. https://ru.m.wikipedia.org/wiki/%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D0%BA%D0%B0_%D0%B2_%D0%A1%D0%A1%D0%A1%D0%A0

CRISPR

CRISPR/Cas9 is a powerful genome editing tool. It is based on an element of the bacterial defense system that biologists have adapted to make changes to DNA. Each time the bacterium manages to kill the virus, it cuts the remnants of its genetic material and stores them inside the CRISPR sequences. This information is then used in the event of a new virus attack. When attacked, the bacterium produces Cas9 proteins, which carry a fragment of the genetic material of the virus. If this region and the DNA of the attacking virus match, Cas9 cuts the genetic material of the latter and neutralizes the threat. The Cas9 protein can be fooled by giving it artificial RNA. A protein carrying such RNA will look for genetic fragments that match what it carries. Having found a match with someone else's DNA, he will begin to grind it. Scientists intend to use CRISPR to cut out mutations from the human genome that are responsible for a range of diseases. https://en.m.wikipedia.org/wiki/CRISPR_gene_editing

Genetic designed people

Now there are already the first GMO people. Their embryonic genomes were edited using CRISPR technology by scientist He Jiankui to prevent their fathers from contracting HIV. After the experiment was announced to the world in 2018, He was condemned as highly unethical. He was imprisoned in China in 2019 and released in April 2022. I consider the condemnation of scientists and the recognition of experiments as unethical a huge problem for the development of science. https://www.newscientist.com/article/mg25533930-700-whats-next-for-the-gene-edited-children-from-crispr-trial-in-china/

Human germline engineering Using germline editing for reproduction is prohibited by law in more than 70 countries

[Darviridis]

Accidentally met genetics and crypto in one project. The developers wanted to create the first mouse with bitcoins in the case. But unfortunately the project is now closed: https://mirror.xyz/0xBd8609CEe8FdD21C477b4D9d0A66B3F4332aFA74

[Darviridis]

Human germline engineering https://en.m.wikipedia.org/wiki/Human_germline_engineering

Designer baby https://en.m.wikipedia.org/wiki/Designer_baby

[Darviridis]

Hox proteins encode and specify the characteristics of 'position', ensuring that the correct structures form in the correct places of the body. https://en.m.wikipedia.org/wiki/Hox_gene#:~:text=Hox%20genes%2C%20a%20subset%20of,correct%20places%20of%20the%20body.

Building artificial Hox genes enables researchers to see how cells learn their location in the body https://www.sciencedaily.com/releases/2022/06/220630142132.htm

[Darviridis]

Scientists have demonstrated that human genes can be controlled with electricity, a breakthrough that could pave the way toward wearable devices that program genes to perform medical interventions, reports a new study https://www.vice.com/en/article/g5yjnx/scientists-control-human-dna-with-electricity-in-leap-forward-study-reports

[Darviridis]

YouTube

https://youtu.be/BpLqnjRv-SU?si=S2_S7ITSb2PILe-I

[Darviridis]

Genome sequencing

sequencing devices: https://nanoporetech.com/products

https://youtu.be/womKfikWlxM?si=hB_2iVjBKz0OKncX

https://youtu.be/Ilaie-g1VG0?si=xWJqXwMM-DKo1KqV

https://youtu.be/W1gE4ZD27LI?si=SC2vjfLpPsD8Ci17