Most of the CPU time spent, in a large (1440x900), full-screen session, on a Release OS X build, appears to be spent doing 68k emulation. Look into using JIT.
To also consider: this may be host CPU cache misses, in which case, JIT might not help.
FS-UAE does appear to include a JIT for x86_64, as indicated at https://fs-uae.net/docs/jit-compiler . If the current UAE 68k emulator in Basilisk II doesn't contain it, perhaps this one could be merged in?
Most of the CPU time spent, in a large (1440x900), full-screen session, on a Release OS X build, appears to be spent doing 68k emulation. Look into using JIT.
To also consider: this may be host CPU cache misses, in which case, JIT might not help.