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DawnEve / txtBlog

[知识管理]A simple yet powerful blog system for reading and organizing txt/Markdown/html files, based on PHP.
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HUMAN CELL ATLAS ASIA MEETING 2020 #11

Open DawnEve opened 4 years ago

DawnEve commented 4 years ago

HUMAN CELL ATLAS ASIA MEETING 2020

A virtual meeting hosted by HCA Asia, October 22nd-23rd 2020

人类细胞图谱（HCA），创建所有人类细胞的全面参考图，作为理解人类健康以及诊断、监测和治疗疾病的基础。

HUMAN CELL ATLAS

HCA Asia meeting 2020 main info.

HCA bilibili channel

DawnEve commented 4 years ago

(day1, AM): Co-current 1-3: Cancer

ZOOM-3 Chair: Woong-Yang Park, Alistair Forrest

Yutaka Suzuki Hae-Ock Lee Ramanuj DasGupta

Yutaka Suzuki: ductal carcinoma of breast cancer | Spatial transcriptome analysis of DCIS/IDC cases using Visium revealed.

(Visium elucidates spatial transcriptome information of cells in nephron segments)

VAFs of TATA3 and PIK3CA in DCIS where ~5%;

Three types of DCIS clusters:

EMT gene set

Microenvironment associated with DCIS and IDC

Question:

DawnEve commented 4 years ago

Hae-Ock Lee: lung cancer, taking the landscape into 治疗

LUAD: lung adenocarcinoma

(1) Activation of humoral immune responses

T cell activation, TCR

脑肿瘤的转移

DawnEve commented 4 years ago

Ramanuj DasGupta: 肿瘤微环境的echoes(录屏11:22 to )

tracking co-evolution of HCC tumors and their ecosystem

Precision Medicine in Liver Cancer Asia-Pacific Network(PLANET)

空间转录组

Fetal-like reprogramming of the TME

A "SCENIC" look at GRNs that determine TAM1 state:

SCENIC identifies HES1 regulon active in TAM1

Macrophages at the feto-maternal interface express markers of TAMs:

单抗联合使用的结果

Question(19min to )

DawnEve commented 4 years ago

(day1, pm) Co-current #2-2: Hematology and Immunology

Chair: Tao Cheng, Shalin Naik

Tao Cheng Shalin Naik Jong Eun Park

Park:

Differential composition of cell types across lifetime

thymus胸腺中的mature T细胞，mouse vs human,

VDJ usage profile of CD8+ T cells

park et al. 2020 Science.

DawnEve commented 4 years ago

dataSet: Mouse developmental heart

Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects

https://www.nature.com/articles/s41586-019-1414-x

https://github.com/MickanAsp/Developmental_heart

DawnEve commented 4 years ago

统计学: Jingyi Jessica Li, scRNA seq simulator

Full-length: smart-seq2, Tag-based: 10x Genomics,

现有的模拟器

dyngen Lun2 powsimR PROSST scDD ...

scDesign2

DawnEve commented 4 years ago

Zheng Zhang: Shenzhen 3rd hospital, scRNAseq reveal ... SARS-CoV-2 infection

cell-cell interaction network //todo

The crosstalk of macrophages /fibroblasts

XCL1, CXCR6, ITGAE, et al

Mild vs Severe infaction model.

scRNAseq - scTCRseq 200,059 cells

Monocytes up; mDC,T,NK down;

MDSC-like cells.