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DepledgeLab / DRUMMER

DRUMMER: Detection of RNA modifications in nanopore direct RNA Sequencing datasets
GNU General Public License v3.0
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scope of the application of DRUMMER #27

Closed fulaibaowang closed 1 year ago

fulaibaowang commented 1 year ago

Hi,

i am wondering how good is xpore detect other RNA modification like ψ and ADP-ribosylation or is it mainly designed for m6A/RNA methylation?

Thanks in advance!

Yun

DepledgeLab commented 1 year ago

I'm going to assume you mean DRUMMER and not xPore (as this is the DRUMMER repository...).

We haven't tested DRUMMER extensively with other modifications (aside from m6A) but as long as a modification produces a change in current that manifests in an increased error rate at (or proximal to) a modified position then DRUMMER should be able to detect it.