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DiseaseNeuroGenomics / variancePartition

Quantify and interpret divers of variation in multilevel gene expression experiments
http://DiseaseNeurogenomics.github.io/variancePartition/
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Analysis of RNA-seq data with variancePartition, also valid for few samples? #2

Closed tim-meese closed 6 months ago

tim-meese commented 7 months ago

Hello authors of variancePartition

Is an analysis with variancePartition valid for experiments with a low sample size? In my specific case, I have only six samples.

Thanks for the feedback.

With kind regards Tim

GabrielHoffman commented 6 months ago

That is on the low side, so the ability the estimate the random effects is pretty low. limma might be a better choice here