Comment for term: DOID:4531

[lschriml]

Submitted by sjwang@mcw.edu

Comment for term: DOID:4531

This term is the parent for 6 mucoepidermoid carcinoma terms. Among them some are not salivary gland origin, for example, bile duct, lung, thymus and trachea mucoepidermoid carcinoma. The definition of mucoepidermoid carcinoma is "A salivary gland carcinoma that is characterized by squamous cells, mucus-secreting cells, and intermediate cells." Either change the definition of DOID:4531 or reorganize the child terms would solve the issue.

[lschriml]

To Do: mv mucoepidermoid carcinoma, to be a child of carcinoma, use axioms to infer anatomical locations

Notes: Mucoepidermoid carcinomas are the most common type of salivary gland cancer. Most start in the parotid glands. They develop less often in the submandibular glands or in minor salivary glands inside the mouth. These cancers are usually low grade, but can sometimes be intermediate or high grade. https://www.cancer.org/cancer/salivary-gland-cancer/about/what-is-salivary-gland-cancer.html

NCI: A carcinoma morphologically characterized the presence of cuboidal mucous cells, goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal formation. It can occur in several anatomic sites, including parotid gland, oral cavity, paranasal sinus, skin, breast, lung, larynx, and lacrimal ducts. It is classified as low or high grade.

https://www.pathologyoutlines.com/topic/salivaryglandsMEC.html Malignant glandular epithelial neoplasm characterized by mucous, intermediate and epidermoid cells, with columnar, clear cell or oncocytoid features

ICD-O: 8430/3 -ICD-O: 8430/3 -

[lschriml]

Notes:

https://www.pathologyoutlines.com/topic/salivaryglandsMEC.html Malignant glandular epithelial neoplasm characterized by mucous, intermediate and epidermoid cells, with columnar, clear cell or oncocytoid features

ICD-O:8430/3- Mucoepidermoid carcinoma

https://www.cancer.org/cancer/salivary-gland-cancer/about/what-is-salivary-gland-cancer.html

Mucoepidermoid carcinomas are the most common type of salivary gland cancer. Most start in the parotid glands. They develop less often in the submandibular glands or in minor salivary glands inside the mouth. These cancers are usually low grade, but can sometimes be intermediate or high grade.

NCI: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C3772

A carcinoma morphologically characterized the presence of cuboidal mucous cells, goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal formation. It can occur in several anatomic sites, including parotid gland, oral cavity, paranasal sinus, skin, breast, lung, larynx, and lacrimal ducts. It is classified as low or high grade.

https://en.wikipedia.org/wiki/Mucoepidermoid_carcinoma Mucoepidermoid carcinoma (MEC) is the most common type of minor salivary gland malignancy in adults. Mucoepidermoid carcinoma can also be found in other organs, such as bronchi, lacrimal sac and thyroid gland.

Mucicarmine staining is one stain used by pathologist for detection.

[lschriml]

I have moved mucoepidermoid carcinoma to be an asserted child of carcinoma,

• created a 'salivary gland mucoepidermoid carcinoma' added a logical axiom to provide inferred parentage to salivary gland carcinoma.