lschriml
commented
6 years ago Hello Mike, I really appreciate your thoughtful requests. It is only through the re-review process that we can keep the DO as up to date and accurate as possible. I think it is important to reassess, in an ongoing basis.
--> looking these over, and researching them: -- two distinct diseases
Hepatocellular carcinoma -- the most common type of liver cancer -- as a carcinoma -- it arises from the epithelial sells of the lining of the liver
whereas adenocarcinoma, arrives from glandular structures in epithelial tissue
--> we have classified hepatic adenocarcinoma as a cell type cancer:
Hepatoid adenocarcinoma - we added this to the DO from NCI was proposed in 1996, for a special type of primary gastric carcinoma characterized by histological resemblance to hepatocellular carcinoma and excessive production of α-fetoprotein (AFP). [Ref https://watermark.silverchair.com/26-4-258.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAcswggHHBgkqhkiG9w0BBwagggG4MIIBtAIBADCCAa0GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMUg7jadNrTH_RMQ9mAgEQgIIBfhM86aAE-2yqY7dmvXpXqhWyYsnGBIB9nG_A59sV0qoBV2nmZCs5Uc5Fc4GmNpBxCwJCkTHtwJT9Aw3GyvAcGv-d2_yvA4TsJQeFMQ1dIchNOwzOstcBNFG-wIIBdYQkdQwqOilXCRcDsygca-d_polWqNbRfDVIRWx0E725S2jx1qMJK0TTluFzP8xt1RJpi7_ldsbukmqCUw_hs_barjGGNIyksZ6Pm1oNg4OksOQPPofe5-qqFTBU-LH9GXq_qxuvZvBXPxjuzGKhVlKAsbh-rw6UHLu0ZWHj8Z1N4KAxA0TDtJqH2jLCGPyrzwi_wkvudaC3fTDLxGF-vA4bBVtxDhgri_y2qNF8Kbs9GPe68KweXPZo-O2WKD6dgmkTE4I_p7YR5vEbWMIVM_e0Pzig9NZn3VB5X_nNSdLfGuJNIBu_bEveNa9nwB8ceMYofn2WRbkoHcIKRN1RYqjOGxSGcToEIlJe2VChjjkRN9idnJGHbtIXKD1E_xS72q0] PubMed https://www.ncbi.nlm.nih.gov/pubmed/24030743 2014 -- can arise in several locations in the body (including: gastric, stomach, pancreas, lung)
Cheers, Lynn
On Fri, Dec 1, 2017 at 10:37 AM, mikelivstone notifications@github.com wrote:
...or at least come clarity on whether it is the same as "hepatocellular carcinoma" (DO:684).
For comparison, note the existence of "hepatoid adenocarcinoma" (DOID_0060534), "An adenocarcinoma with morphologic characteristics similar to hepatocellular carcinoma, arising from an anatomic site other than the liver.
In other words, I can't tell if hepatocellular _adeno_carcinoma is a synonym for or subtype of hepatocellular carcinoma (or if it is even a real disease).
Sorry for the nebulous request.
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-- Lynn M. Schriml, Ph.D. Associate Professor
Institute for Genome Sciences University of Maryland School of Medicine Department of Epidemiology and Public Health 801 W. Baltimore St., Room 659 Baltimore, MD 21201 P: 410-706-6776 | F: 410-706-6756 lschriml@som.umaryland.edu
mikelivstone
...or at least come clarity on whether it is the same as "hepatocellular carcinoma" (DO:684).
For comparison, note the existence of "hepatoid adenocarcinoma" (DOID_0060534), "An adenocarcinoma with morphologic characteristics similar to hepatocellular carcinoma, arising from an anatomic site other than the liver.
In other words, I can't tell if hepatocellular _adeno_carcinoma is a synonym for or subtype of hepatocellular carcinoma (or if it is even a real disease).
Sorry for the nebulous request.