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EBISPOT / CMPO

Cellular Microscopy Phenotype Ontology
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new terms terms describing movement and density of cells #5

Open siiraa opened 6 years ago

siiraa commented 6 years ago

A new study in the Image Data Resource looking at Cytotoxic T lymphocytes (CTL) in tumors has the following phenotypes that we might want to add new CMPO terms for.

  1. increased CTL confinement - this is where the cells move around but don't go very far, so I don't think its quite the same as "decreased cell movement distance", CMPO_0000239
  2. enhanced CTL killing - related to "cell killing", http://purl.obolibrary.org/obo/GO_0001906
  3. enhanced CTL density
  4. transient increase in CTL density

I've already mapped:

  1. reduced CTL speed - mapped to "decreased cell movement speed"(CMPO_0000240)
  2. enhanced CTL proliferation - mapped to "proliferating cells" CMPO_0000241

And I think the final 2 phenotypes are beyond the scope of CMPO

  1. reduced tumor growth (could be mapped to "decreased tumor growth/size", http://purl.obolibrary.org/obo/MP_0003447
  2. vessel normalization
siiraa commented 6 years ago

Simon Jupp added a comment - 25-Apr-17 12:13

CMPO:0000449 - T cell mediated killing against a tumor cell phenotype

siiraa commented 6 years ago

Simon Jupp added a comment - 25-Apr-17 12:20

waiting for more term movement phenotypes - unsure of quality of "cells move around but don't go very far"