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EBISPOT / efo

Github repo for the Experimental Factor Ontology (EFO)
https://www.ebi.ac.uk/efo/
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New term request for GWAS (PMID:32123936) #1085

Closed Santhi1901 closed 3 years ago

Santhi1901 commented 3 years ago

For new term requests, please provide the following information:

Preferred term label

response to mycobacterium Bovis BCG

Synonyms

NA

Textual definition

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of mycobacterium Bovis BCG vaccine.

Suggested parent term

response to vaccine- http://www.ebi.ac.uk/efo/EFO_0004645

Attribution

NA

kallia-p commented 3 years ago

I think a more informative parent term is 'response to antineoplastic agent' instead of 'response to vaccine'. Mycobacterium Bovis BCG is an intravesical immunotherapy for bladder cancer. (Another type of intravesical therapy for bladder cancer is chemotherapy with drugs). https://www.cancer.org/cancer/bladder-cancer/treating/intravesical-therapy.html#:~:text=Bacillus%20Calmette%2DGuerin%20or%20BCG,t%20usually%20cause%20serious%20disease. see text therein: "Bacillus Calmette-Guerin or BCG is the most common intravesical immunotherapy for treating early-stage bladder cancer." On the other hand BCG is a also considered a vaccine (used also for tuberculosis) see NCIT http://purl.obolibrary.org/obo/NCIT_C298.

In EFO under parent term 'response to antineoplastic agent' we have the child 'response to immunochemotherapy' which refers to immunotherapy and chemotherapy combination treatment so perhaps we need to add a class 'response to immunotherapy' with optionally a child term 'response to vaccine immunotherapy' that BCG could be a Subclass Of.

I would suggest to add parent term 'response to antineoplastic agent' and open a linked follow-up ticket with suggestions for improving this.

kallia-p commented 3 years ago

@Santhi1901 @zoependlington Added new term ‘response to BCG intravesical immunotherapy’’ EFO_0011041 ('response to mycobacterium Bovis BCG' added as a synonym term) under parent term ‘response to antineoplastic agent’ GO_0097327 This term will be available in the next release. A follow-up ticket has been opened with suggestions to re-structure the 'response to antineoplastic agent' branch https://github.com/EBISPOT/efo/issues/1099