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EBISPOT / efo

Github repo for the Experimental Factor Ontology (EFO)
https://www.ebi.ac.uk/efo/
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Review EFO_0005761 branch #1414

Open ireneisdoomed opened 2 years ago

ireneisdoomed commented 2 years ago

Hi!

Lupus nephritis (EFO_0005761) is defined as glomerulonephritis always in the context of systemic lupus erythematosus (EFO_0002690). This dependency is not captured in the ontology, since LP is not defined as a child of SLE.

Could you please review this term to evaluate whether having SLE as a descendant of SLE is a more proper definition?

To provide a bit more context, Voclosporin is a drug targeting PPP3CA that has been recently approved for Lupus Nephritis. We were doing the exercise of retrieving how well this new indication is backed by genetic evidence. For that, the ontology is propagated to also search for evidence among the parents of lupus nephritis. By having LP being a descendant of SLE, we will be capturing the genetic evidence between SLE and PPP3CA.

Thank you very much!

zoependlington commented 2 years ago

NOTE TO SELF: Currently lupus nephritis is classified (from Mondo) as: Equivalent to: glomerulonephritis and (disease arises from feature some systemic lupus erythematosus)