I am working with the ecoli version of the ETFL model. Im attempting to integrate transcriptomics data similar to the transcriptomics.py in the integration sub module. Im wondering what the assumptions are around the distribution of the integrated data? I am assuming that the bounds for each transcript need to be between 0 and 1, but, I am asking about the spread of the bounds (lower and upper) for each transcript in the model. Does it matter if most of the bounds are skewed to be closer to 0, closer to 1, or fairly homogeneous? Thanks for any insights.
Hi,
I am working with the ecoli version of the ETFL model. Im attempting to integrate transcriptomics data similar to the transcriptomics.py in the integration sub module. Im wondering what the assumptions are around the distribution of the integrated data? I am assuming that the bounds for each transcript need to be between 0 and 1, but, I am asking about the spread of the bounds (lower and upper) for each transcript in the model. Does it matter if most of the bounds are skewed to be closer to 0, closer to 1, or fairly homogeneous? Thanks for any insights.