EddyRivasLab / hmmer

HMMER: biological sequence analysis using profile HMMs
http://hmmer.org
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Marginal hits late in target might be filtered in an nhmmer search #112

Closed traviswheeler closed 7 years ago

traviswheeler commented 7 years ago

ID h102 TITLE Marginal hits late in target might be filtered in an nhmmer search AFFECTS 3.1b1 FIXED_IN 3.1b2 STATUS CLOSED XREF - REPORTED_BY Jim Notwell jimnotwell@gmail.com OPENED_DATE TJW, Tue Sep 03 23:407:30 2013 CLOSED_DATE
DESCRIPTION
In a late stage of the nhmmer acceleration pipeline, sequence windows passing the Forward filter were subjected to a significance test and filtered if the estimated E-value was above threshold. This test proved not to be conservative, with the result that some marginal hits were filtered when they shouldn't have been. The test was removed, with no noticable impact on speed.