EddyRivasLab / hmmer

HMMER: biological sequence analysis using profile HMMs
http://hmmer.org
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No description found on DESC line for hmm built using hmmbuild #298

Closed alex-hh closed 1 year ago

alex-hh commented 1 year ago

Hi - I'm trying to build an hmm using a command like hmmbuild profile.hmm uniref90_hits.sto

And then align sequences to it with hmmalign profile.hmm sequences.fa

However I get the following error:

Error: Bad file format in HMM file profile.hmm:
No description found on DESC line

The top of the HMM file is as follows:

HMMER3/f [3.3.2 | Nov 2020]
NAME  5u9cA
DESC  
#=GC RF                          SNAMKRK-ILITGG-T-G-M-L-G----A-----Y----V-------T------S-------A----------L------------K---------D------------T------------D---------Y----------N---------V------------I----------V---------T------------E-----------R------------------N---------------T--------------L-----------N-----------L-------------S-------------V--------P-------------E-------------A----------I------------F------------S------------Y--------------I----T----------A-----E--------------K-----------P-D---V--ILHFAA-ETDVDLCE--R---E-----P-----A---R-----A--G---I--Y---N-----H----L-A-TEQIA-Q--A-----A---K-F------C-------G------A------W---L--------LYLSS----SNVF----G------G-------E-----------G---------K-------L-------S----------Y--N---E----L------D--I---P----L----------P---M-N-YYGRSKLIGE---S-S-V---R--N-----A-------C-----T------N-------N----H----L------IIRA----G----WM---I--G-----G----G---P-------D---------K-------D-------------H----K---F-------V----G--K--------I--I----Q-------Q-----I-------K---A----------------G------S---T--S------I---K---A-----V--S--D-R--L-G-------------S------I--------T--------------S------------A--------M-----------Q------L---------------C----------N--------F-----------I----------I-------------W-----------A------------I-----------N--------------K-----------R--------------H-------------T------------G----------T----------L--------H-----F-------A----S----S-----G-----T-----I-----S-------R-------F-------D-------I-------A--------C-------A------I--------G-------D---------L-------L------N--------F--------K--------G---------D--------I---------I--------P--------V----H--------S-----S--------V----F-----P--------L---S-----A---P--R-P-YS--E--G--I--E--S--I--Y--M--S--I-----L--S-D-----A--P--K---P--S-L---WKSDLAK-YVGTFLV

Would appreciate any help in resolving this issue. Thanks!

cryptogenomicon commented 1 year ago

There's no description on the DESC line. Delete the DESC line.

alex-hh commented 1 year ago

got it thanks!