EnvironmentOntology / environmental-exposure-ontology

Modular environmental exposures ontology
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NTR: Food poisoning, viral #71

Closed laurenechan closed 2 years ago

laurenechan commented 4 years ago

Overarching Issue: #69

Label: exposure to food poisoning (viral)

Definition: Episode(s) of acute gastrointestinal illness caused by the ingestion of a viral pathogen or unspecified viral agents.

Parent: exposure to food poisoning

Will need to create an "exposure to food poisoning" in general as well

References: PMID: 21192849

Synonyms: foodborne illness, foodborne disease,

ORCID: 0000-0002-7463-6306

cmungall commented 4 years ago

So there are some interesting challenges here. The definitions and synonyms are written as if there are diseases

We have classes like 'foodborn botulism' in MONDO http://purl.obolibrary.org/obo/MONDO_0016453

how should these be coordinated with ECTO?

In ECTO, should we have exposure to disease/condition as a pattern? (@diatomsRcool asked this here https://github.com/EnvironmentOntology/environmental-exposure-ontology/issues/69#issuecomment-565615506)

Or should we stick to exposure to virus/bacteria/etc, and leave the consequences of that exposure out of ECTO?

laurenechan commented 4 years ago

Continuing on @cmungall 's thought, maybe we don't need to model exposure to both the disease state and the pathogen.

Consider these instances: Exposure to E.Coli VS exposure to food poisoning (bacterial) Individuals are regularly exposed to E. Coli, yet do not consistently experience food poisoning from that exposure. Will there be significant impacts of exposure to the E. Coli and separately significant impacts from food poisoning exposure? Even if there are significant outcomes from E.Coli food poisoning, are they better modeled in Mondo (if they aren't already)?

I spoke with @nicolevasilevsky about this, and it sounds as though it may be beneficial to only model exposures that are external from the individual (ex. exposure to norovirus or exposure to shared hypodermic needles) as opposed to disease/phenotype exposures that are outcomes of such exposures.

diatomsRcool commented 4 years ago

Perhaps it should be "exposure to tainted food"?

laurenechan commented 4 years ago

We likely will want (eventually) terms for 'exposure to X viral component' or 'exposure to Y bacterial component' via ingestion, but would we actually want to have an 'exposure to contaminated food' type of term? @diatomsRcool we had spoken some about using food as a medium, which works alright for exposure to things external to the food (like a contaminant), but not necessarily well for things inherent to the food (like nutrients).

Do we have a further thought as to how we want to use/not use food as a medium to guide this decision?

diatomsRcool commented 4 years ago

exposure to X viral component in food via ingestion - is probably fine. What would one use if they know they have food poisoning, but are unsure of the actual microbe?

laurenechan commented 4 years ago

@diatomsRcool We would probably need an 'exposure to infectious food' or 'exposure to unknown infectious agent', something like that to capture the unknown microbe leading to food borne illness.