As a bioinformatician, I would like to pool the individual DNA methylation calls from a set of cells, to create a bulk DNA methylation profile, in order to do DMR calling, and to determine methylation profiles for particular cell types.
Estimate
2 hours
Priority
MUST
Notes
Input: DNA methylation data for all cells (TSV-like format), a list of which cells to pool
Output: DNA methylation data in TSV-like format, but pooled
Some collaborators of mine have been calling this in-silico merging - Kieran
I have some code I'm willing to share to do this, so it basically just needs to be wrapped in CWL. - Kieran
Description
As a bioinformatician, I would like to pool the individual DNA methylation calls from a set of cells, to create a bulk DNA methylation profile, in order to do DMR calling, and to determine methylation profiles for particular cell types.
Estimate
2 hours
Priority
MUST
Notes