We have 4 of these in FBbt (LT1, LT2, LT3 & LT4) based on FBrf0099344 (Landgraf et al., 1997 -S16 embryo), all following SNa. LT1 and LT2 MNs from NB2-2, LT3 and LT4 MNs from NB3-2.
FBrf0132289 (Hoang and Chiba, 2001 - 3rd instar) report only three types, innervating LT1 (21)/LT2 (22), LT2 (22)/LT3 (23) and LT3 (23)/LT4 (24)
FBrf0209293 (Kim et al., 2009 - 3rd instar) also identify MN21/22-Ib and MN22/23-Ib, consistent with Hoang and Chiba (2001).
FBrf0195092 (Garces et al., 2006 - 3rd instar) seems to support Landgraf et al. (1997), but says that LT1 and LT2 (NB2-2 derivatives) and LT3 and LT4 (NB3-2 derivatives) are quite similar within each pair and does not look at single cells, so unclear what is separate neurons/branches of the same neuron
FBrf0112030 (Schmid et al., 1999 - S15-17 embryo) say 2 NB2-2 MNs innervate LT1-3 (21-23) and that there are 2 SNa NB3-2 MNs, at least one of which innervates LT4 (24) (and perhaps LT3)
EM shows only three types (LT1/LT2, LT2/LT3 & LT3/LT4) - FBrf0244727 (Zarin et al., 2019 - early 1st instar), although the same data was originally interpreted as four types in FBrf0233076 (Zwart et al., 2016). Looking at the skeletons of these neurons, LT1/2 and LT2/3 look more similar(and may follow same primary neurite tract) and have more similar connectivity (FBrf0244727 Fig 5) to each other than to LT3/4
Taken together, this suggests that LT1/LT2 and LT2/LT3 may correspond to LT1 and LT2, and that LT3 and LT4 might both correspond to LT3/4. Not currently clear if LT3 and LT4 should be merged or if LT3/4 needs creating as a superclass. Need to find further information and add to this ticket.
Clare72
commented
1 year ago
We have 4 of these in FBbt (LT1, LT2, LT3 & LT4) based on FBrf0099344 (Landgraf et al., 1997 -S16 embryo), all following SNa. LT1 and LT2 MNs from NB2-2, LT3 and LT4 MNs from NB3-2. FBrf0132289 (Hoang and Chiba, 2001 - 3rd instar) report only three types, innervating LT1 (21)/LT2 (22), LT2 (22)/LT3 (23) and LT3 (23)/LT4 (24) FBrf0209293 (Kim et al., 2009 - 3rd instar) also identify MN21/22-Ib and MN22/23-Ib, consistent with Hoang and Chiba (2001). FBrf0195092 (Garces et al., 2006 - 3rd instar) seems to support Landgraf et al. (1997), but says that LT1 and LT2 (NB2-2 derivatives) and LT3 and LT4 (NB3-2 derivatives) are quite similar within each pair and does not look at single cells, so unclear what is separate neurons/branches of the same neuron FBrf0112030 (Schmid et al., 1999 - S15-17 embryo) say 2 NB2-2 MNs innervate LT1-3 (21-23) and that there are 2 SNa NB3-2 MNs, at least one of which innervates LT4 (24) (and perhaps LT3) EM shows only three types (LT1/LT2, LT2/LT3 & LT3/LT4) - FBrf0244727 (Zarin et al., 2019 - early 1st instar), although the same data was originally interpreted as four types in FBrf0233076 (Zwart et al., 2016). Looking at the skeletons of these neurons, LT1/2 and LT2/3 look more similar(and may follow same primary neurite tract) and have more similar connectivity (FBrf0244727 Fig 5) to each other than to LT3/4
Taken together, this suggests that LT1/LT2 and LT2/LT3 may correspond to LT1 and LT2, and that LT3 and LT4 might both correspond to LT3/4. Not currently clear if LT3 and LT4 should be merged or if LT3/4 needs creating as a superclass. Need to find further information and add to this ticket.